[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100344112":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":35,"responsibleParty":53,"collaborators":56,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":20,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":20,"enrollmentInfo":69,"targetDuration":20,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":38,"whyStopped":20,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Oregon Health and Science University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Surgery","EXPERIMENTAL","OCT-guided custom laser CXL",[13],"Procedure: Laser Custom Corneal Collagen Cross-Linking",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Laser Custom Corneal Collagen Cross-Linking","Preoperative measurements from the OCT are used to assist the calculation in deciding the laser depth settings for smoothing the anterior corneal surface and removing any present opacities. The surgeon uses the OCT data to plan treatment parameters while preserving at least 360 microns of residual corneal stroma using a phototherapeutic keratectomy procedure. After the laser procedure, adjunctive MMC or saline solution will be applied to the cornea in accordance with the group to which the treated eye is randomized. The CXL procedure is then performed following the FDA-approved CXL regimen by Avedro, Inc.",[9],null,[22],{"name":23,"affiliation":5,"role":24},"David Huang, MD, PhD","PRINCIPAL_INVESTIGATOR",[26,31],{"name":27,"role":28,"phone":29,"phoneExt":20,"email":30},"Denzil Romfh, OD","CONTACT","503-494-4351","romfhd@ohsu.edu",{"name":32,"role":28,"phone":33,"phoneExt":20,"email":34},"Humberto Martinez, COT","503-494-7712","martinhu@ohsu.edu",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Oregon Health & Science University","RECRUITING","Portland","Oregon","97239","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-122.67621,45.52345,{"lat":48,"lon":47},[51,52],{"name":27,"role":28,"phone":29,"phoneExt":20,"email":30},{"name":32,"role":28,"phone":33,"phoneExt":20,"email":34},{"type":24,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"David Huang","Peterson Professor of Ophthalmology & Professor of Biomedical Engineering",[57],{"name":58,"class":59},"National Eye Institute (NEI)","NIH","100344112","collagen-cross-linking-in-keratoconus-100344112",false,"NCT03760432","Collagen Cross-linking in Keratoconus","Clinical Trial of Laser Custom Corneal Collagen Cross-Linking in Keratoconus","Inclusion Criteria:\n\n* Diagnosis of keratoconus\n* Minimum corneal thickness of 410 microns\n\nExclusion Criteria:\n\n* Inability to maintain fixation for OCT imaging\n* Inability to commit to required study visits\n* Inability to give informed consent\n* Eyes with concurrent retinal diseases, glaucoma, or other eye conditions that may limit the visual outcome after surgery\n* Mature cataracts if found to limit visual potential to worse than 20\u002F40","ALL","18 Years",{"count":70,"type":71},100,"ESTIMATED","INTERVENTIONAL",[74],"NA","Optical Coherence Tomography (OCT) devices are non-contact instruments that can measure the depth of scars, other causes of cloudiness of the cornea, and degree of corneal thinning in patients with keratoconus. Laser Custom Corneal Collagen Cross-linking (CXL) significantly decreases corneal aberrations and improves vision. This study will use OCT-guided setting for the lasers used in the corneal smoothing portion of the laser custom CXL procedure to assess the affect on visual outcomes.",[77],"Keratoconus",[79,80,81],"Keratoconus (KCN)","Optical Coherence Tomography (OCT)","Collagen Cross-linking (CXL)","2025-09-05",{"date":84,"type":85},"2025-09-09","ACTUAL",{"date":87,"type":85},"2018-06-20",{"date":89,"type":71},"2027-12",{"name":5,"class":6},1]