[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628039":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":57,"collaborators":61,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":26,"eligibilityCriteria":71,"healthyVolunteers":72,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":26,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":87,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"University of Vienna","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Collagen Peptides","EXPERIMENTAL","Participants receive daily oral supplementation with specific collagen peptides for 24 weeks. Allocation is randomized 1:1 and double-blinded against placebo. Study visits occur at baseline (T0), 3 months (T1), and 6 months (T2). Blood samples are collected to assess telomere length (qPCR T\u002FS ratio) and telomerase activity (TRAP), alongside inflammation and redox markers. Body composition (bioelectrical impedance), functional tests (muscle strength, mobility), and questionnaires on health and vitality are also performed. The intervention aims to test whether six months of collagen peptides stabilize or extend telomeres and increase telomerase activity compared with placebo.",[13],"Dietary Supplement: Collagen peptides",{"label":15,"type":16,"description":17,"interventionNames":18},"Maltodextrin","PLACEBO_COMPARATOR","Participants receive a daily placebo matched in a double-blind design for 24 weeks, with the same schedule of study visits at T0, T1, and T2 and the same assessments (blood biomarkers of telomere biology, inflammation\u002Fredox; body composition; functional tests; questionnaires) as the verum arm. Maltodextrin serves as the control to compare effects against collagen peptides in a randomized, double-blind, placebo-controlled, parallel-group trial.",[19],"Dietary Supplement: Maltodextrin (Placebo)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Collagen peptides","Collagen peptides (oral daily supplementation), taken once daily for 24 weeks in a randomized 1:1, double-blind design; primary outcomes: telomere length (qPCR T\u002FS) and telomerase activity (TRAP), with inflammatory\u002Fredox markers as secondary endpoints.\n\nTarget population: adults 50-70 years with BMI 25-30 and low-to-moderate activity; vegetarians\u002Fvegans excluded due to animal-derived collagen.\n\nMatched maltodextrin placebo, identical dosing and visit schedule (T0, T1, T2), serving as the comparator to isolate collagen peptide effects in the parallel-group, double-blind trial.\n\nProducts are approved as foods; prior clinical studies reported no substance-related adverse effects.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Maltodextrin (Placebo)","Placebo instead of the collagen peptides",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Daniel König, Univ. Prof. Dr.","CONTACT","+43-1-4277-59130","daniel.koenig@univie.ac.at",[38],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"University of Vienna, NuTraLab","RECRUITING","Vienna","State of Vienna","1070","Austria","AT",{"type":47,"coordinates":48},"Point",[49,50],16.37208,48.20849,{"lat":50,"lon":49},[53],{"name":54,"role":34,"phone":55,"phoneExt":26,"email":56},"Jana Schneider","+43-1-9909194-200","jana.schneider@univie.ac.at",{"type":58,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Daniel König","Univ. Professor Dr.",[62],{"name":63,"class":64},"CRI Collagen Research Institute GmbH","UNKNOWN","100628039","collagen-peptides-and-cellular-aging-100628039",false,"NCT07456449","Collagen Peptides and Cellular Aging","Collagen Peptides and Cellular Aging: a Randomized, Placebo-controlled Intervention Study on Telomere Length, Inflammation, Body Composition, and Functional Capacity in Middle-aged and Older Adults","Inclusion Criteria:\n\n* Adults aged 50-70 years; both male and female participants are eligible\n* Body mass index (BMI) 25-30 kg\u002Fm²\n* Low to moderate physical activity: not meeting current WHO recommendations (\\\u003C150 minutes\u002Fweek) or ≤2 sessions\u002Fweek structured training\n* Able to live independently and mobile in daily life\n* No regular resistance training within the past 6 months\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Diagnosed chronic diseases relevant to the immune system, metabolism, or cellular aging (e.g., diabetes mellitus, cancer, cardiovascular, rheumatologic diseases)\n* Use of immunomodulatory, systemic anti-inflammatory, or hormonal medications (e.g., corticosteroids, immunosuppressants)\n* Acute infections or surgeries within the last 3 months\n* Regular use of supplements known to affect oxidative stress or cellular aging (e.g., high-dose antioxidants, CoQ10, omega-3 fatty acids, high-dose vitamin D)\n* Participation in another clinical study within the last 3 months\n* Vegetarian or vegan diet (product contains animal-derived collagen)",true,"ALL","50 Years","70 Years",{"count":77,"type":78},125,"ESTIMATED","INTERVENTIONAL",[81],"NA","The goal of this clinical trial is to learn if daily collagen peptide supplementation can stabilize or lengthen telomeres and improve related markers of cellular aging in adults aged 50-70 years with overweight and low-to-moderate physical activity (healthy volunteers without major chronic disease).\n\nMain questions it aims to answer are:\n\nDoes six months of collagen peptides stabilize or extend telomere length and increase telomerase activity compared with placebo? Are any telomere-related changes associated with lower inflammation, healthier body composition, and better functional health?\n\nResearchers will compare collagen as an intervention to a placebo group to see if collagen will influence aging markers.\n\nParticipants will take collagen peptides or a placebo daily for 24 weeks. They will attend three study visits: one before starting the intervention (T0), one at 3 months (T1), and one at 6 months (T2). At each visit, blood samples will be collected to measure telomere length, telomerase activity, and inflammation\u002Fredox markers. Participants will also undergo body composition assessments using bioelectrical impedance, complete functional tests of muscle strength and mobility, and fill out questionnaires on health and vitality.",[84,85,86],"Longevity","Healthy Aging","Biological Ageing",[88,89,90,91,92,93],"Aging","Collagen","Supplements","Patient Care","Healthspan","Cellular aging","2026-04-28",{"date":96,"type":97},"2026-05-05","ACTUAL",{"date":99,"type":97},"2026-04-22",{"date":101,"type":78},"2028-08",{"name":5,"class":6},1]