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Must be 45-84 years of age.\n2. Must have a suspected advanced adenoma or be newly diagnosed with CRC, still not resected, and scheduled for surgery.\n3. Able to comprehend, sign, and date the written informed consent document.\n\nArm B:\n\n1. Must be 45-84 years of age.\n2. Able and willing to undergo a standard-of-care screening colonoscopy within 60 days.\n3. Able to comprehend, sign, and date the written informed consent document.\n\nExclusion Criteria:\n\nArm A Only:\n\n1\\. Subject with curative biopsy during colonoscopy.\n\nArm B Only:\n\n1. Subjects with positive FIT Test results in the 6 months preceding enrollment.\n2. Subject has a current diagnosis of cancer.\n\nArms A \\& B:\n\n1. Subject has a personal history of aerodigestive or digestive tract cancers.\n2. Subjects having undergone previous partial surgical removal of one or more portions of their colon due to a reason other than colorectal cancer.\n3. 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The patient has a known or documented previous or current medical history of infectious diseases that can be transmitted through blood (E.g. Hepatitis, HIV, etc.), including patients that have been treated, are currently being treated, or have not been treated for that conditions.\n8. The patient is known to be pregnant when recruited or during her participation in the study.",true,"ALL","45 Years","84 Years",{"count":205,"type":206},1300,"ESTIMATED","OBSERVATIONAL","A prospective multi-center observational study. The study will enroll eligible subjects from the United States to optimize the biomarker panel and evaluate the performance of a cfDNA marker panel selected by the Sponsor for CRC and advanced adenoma detection.",[210,211],"Colorectal Cancer (CRC)","Advanced Adenomas (AA)","2025-11-05",{"date":214,"type":215},"2025-11-10","ACTUAL",{"date":217,"type":215},"2020-12-30",{"date":219,"type":206},"2025-12-30",{"name":5,"class":6},16]