[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626469":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":50,"collaborators":26,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":26,"eligibilityCriteria":59,"healthyVolunteers":56,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":26,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":26,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"King Abdulaziz University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Nano-hydroxyapatite Toothpaste Group","EXPERIMENTAL","Participants in this group will use Nano-hydroxyapatite toothpaste for 9 months to assess its effect on reducing caries, improving aesthetics, and decreasing sensitivity.",[13],"Device: Nano-hydroxyapatite Toothpaste",{"label":15,"type":16,"description":17,"interventionNames":18},"Fluoridated Toothpaste Group","ACTIVE_COMPARATOR","Participants in this group will use fluoridated toothpaste (1450 ppm fluoride) three times daily under parental supervision for 9 months.",[19],"Device: Fluoridated Toothpaste",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Fluoridated Toothpaste","Participants will use fluoridated toothpaste (1450 ppm fluoride) three times daily under parental supervision for 9 months to compare its effects with Nano-hydroxyapatite.",[15],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Nano-hydroxyapatite Toothpaste","Participants in this group will brush their teeth with Nano-hydroxyapatite toothpaste three times daily under parental supervision for 9 months to evaluate its impact on caries reduction, aesthetics, and sensitivity.",[9],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"sabbagh","CONTACT","+966 50 566 8481","hjsabbagh@gmail.com",[38],{"facility":39,"status":40,"city":41,"state":26,"zip":26,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":26},"King Abdulaziz University Hospital, Jeddah, Saudi Arabia","RECRUITING","Jeddah","Saudi Arabia","SA",{"type":45,"coordinates":46},"Point",[47,48],39.18624,21.49012,{"lat":48,"lon":47},{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Heba sabbagh","Principal Investigator","100626469","color-change-and-desensitization-of-molar-incisor-hypomineralization-affected-enamel-using-biomimetic-nano-hydroxyapatite-toothpaste-100626469",false,"NCT07436039","Color Change and Desensitization of Molar Incisor Hypomineralization-Affected Enamel Using Biomimetic Nano-Hydroxyapatite Toothpaste","Inclusion Criteria:\n\n\\- Children aged 6-12 years.\n\n* Diagnosed with Molar-Incisor Hypomineralization (MIH) in at least one first permanent molar or hypomineralization of a second primary molar (HSPM).\n* Presence of white, creamy, yellow, or brown demarcated opacities\n* Indexed teeth include permanent first molars and permanent maxillary incisors.\n\nExclusion Criteria:\n\n* • Decayed permanent molars.\n\n  * Diabetes, hypertension, sleeping disorders, or allergic reactions to medications.\n  * Children on medication\n  * Presence of other enamel defects (e.g., fluorosis, amelogenesis imperfecta, enamel hypoplasia, or white spot lesions).\n  * Previous treatment with liquid enamel or other remineralizing agents on affected teeth.","ALL","6 Years","12 Years",{"count":64,"type":65},60,"ESTIMATED","INTERVENTIONAL",[68],"NA","This clinical trial aims to evaluate if nano-hydroxyapatite (Nano-HA) toothpaste effectively treats children with Molar-Incisor Hypomineralization (MIH). It will also assess the safety of Nano-HA toothpaste. The main questions are:\n\n* Does Nano-HA toothpaste reduce caries incidence, improve tooth aesthetics, and decrease hypersensitivity?\n* How does Nano-HA compare to fluoridated toothpaste in terms of outcomes?\n\nParticipants will:\n\n* Use Nano-HA or fluoridated toothpaste daily for 12 months.\n* Visit the clinic for checkups and evaluations every 1 to 3 months.\n* Record symptoms, brushing compliance, and sensitivity.\n\nThe study will compare Nano-HA toothpaste to fluoridated toothpaste to determine its efficacy in managing MIH .",[71],"Molar-Incisor Hypomineralization (MIH)","2026-02-21",{"date":74,"type":75},"2026-02-27","ACTUAL",{"date":77,"type":75},"2025-10-01",{"date":79,"type":65},"2027-07-01",{"name":5,"class":6},1]