[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640495":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":36,"centralContacts":41,"locations":47,"responsibleParty":62,"collaborators":27,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":66,"sex":72,"minAge":73,"maxAge":27,"enrollmentInfo":74,"targetDuration":27,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":84,"overallStatus":92,"whyStopped":27,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Ramsay Générale de Santé","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Combined Distal Femoral Nerve Block","EXPERIMENTAL","Participants receive an ultrasound-guided combined distal femoral nerve block targeting the saphenous nerve, vastus medialis nerve, and anterior femoral cutaneous nerves, using ropivacaine 2 mg\u002FmL, 40 mL total, with clonidine 30 micrograms perineural and dexamethasone 8 mg IV. They also receive surgical site infiltration, general anesthesia, and standard multimodal analgesia.",[13,14],"Procedure: Combined distal femoral nerve block","Procedure: Standard perioperative care in both groups",{"label":16,"type":17,"description":18,"interventionNames":19},"Saphenous Nerve Block Alone","ACTIVE_COMPARATOR","Participants receive an ultrasound-guided saphenous nerve block at the adductor canal using ropivacaine 2 mg\u002FmL, 20 mL total, with clonidine 30 micrograms perineural and dexamethasone 8 mg IV. They also receive surgical site infiltration, general anesthesia, and standard multimodal analgesia.",[20,14],"Procedure: Saphenous nerve block alone",[22,28,32],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"PROCEDURE","Combined distal femoral nerve block","Ultrasound-guided block targeting the saphenous nerve, vastus medialis nerve, and anterior femoral cutaneous nerves, using ropivacaine 2 mg\u002FmL, 40 mL total, with clonidine 30 micrograms perineural and dexamethasone 8 mg IV.",[9],null,{"type":23,"name":29,"description":30,"armGroupLabels":31,"otherNames":27},"Saphenous nerve block alone","Ultrasound-guided saphenous nerve block at the adductor canal, using ropivacaine 2 mg\u002FmL, 20 mL total, with clonidine 30 micrograms perineural and dexamethasone 8 mg IV.",[16],{"type":23,"name":33,"description":34,"armGroupLabels":35,"otherNames":27},"Standard perioperative care in both groups","General anesthesia, surgical site infiltration, and multimodal analgesia with paracetamol, nefopam, and ketoprofen.",[9,16],[37],{"name":38,"affiliation":39,"role":40},"Antoine Sanchez, MD","Hôpital privé Dijon Bourgogne","PRINCIPAL_INVESTIGATOR",[42],{"name":43,"role":44,"phone":45,"phoneExt":27,"email":46},"Antoine Sanchez","CONTACT","+33 3 80 40 01 14","sanchez.antoine@live.fr",[48],{"facility":39,"status":27,"city":49,"state":27,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Dijon","21000","France","FR",{"type":54,"coordinates":55},"Point",[56,57],5.01391,47.31344,{"lat":57,"lon":56},[60],{"name":61,"role":44,"phone":45,"phoneExt":27,"email":46},"Antoine SANCHEZ, Dr",{"type":63,"investigatorFullName":27,"investigatorTitle":27,"investigatorAffiliation":27,"oldNameTitle":27,"oldOrganization":27},"SPONSOR","100640495","combined-distal-femoral-nerve-block-for-pain-control-after-knee-replacement-100640495",false,"NCT07629388","Combined Distal Femoral Nerve Block for Pain Control After Knee Replacement","Comparative Study Assessing the Efficacy of a Combined Distal Femoral Nerve Block for Postoperative Analgesia Following Total Knee Arthroplasty (TKA)","FEM-COMB","Inclusion Criteria:\n\n* Adult patients aged over 18 years.\n* Scheduled for total knee arthroplasty with multimodal analgesia.\n* Affiliated with or benefiting from a social security system.\n* Able to understand the study information and provide written informed consent.\n\nExclusion Criteria:\n\n* Emergency surgery.\n* Weight under 50 kg.\n* Body mass index over 40 kg\u002Fm².\n* Contraindication to nefopam, non-steroidal anti-inflammatory drugs, local anesthetics, or morphine.\n* Preoperative opioid use.\n* Antidepressant or gabapentinoid treatment.\n* Other planned surgical or medical procedures during the study period.\n* Participation in another clinical trial, or currently in an exclusion period from another trial.\n* Inability to understand study information for linguistic, psychological, cognitive, or literacy reasons.\n* Pregnancy, possible pregnancy without effective contraception, or breastfeeding.\n* Protected adults, including those under guardianship, curatorship, legal protection, detention, or otherwise unable to give informed consent.","ALL","18 Years",{"count":75,"type":76},240,"ESTIMATED","INTERVENTIONAL",[79],"NA","The goal of this clinical trial is to see whether a combined distal femoral nerve block improves pain relief after total knee replacement in adults having planned surgery. The main questions it aims to answer are:\n\n* Does the combined distal femoral nerve block reduce the amount of opioid needed in the post-anesthesia recovery room?\n* Does it preserve quadriceps muscle strength while improving postoperative pain control?\n\nResearchers will compare the combined distal femoral nerve block to a saphenous nerve block alone to see if the combined block provides better analgesia without reducing leg strength.\n\nParticipants will:\n\n* Receive either the combined distal femoral nerve block or the saphenous nerve block alone before surgery.\n* Also receive standard multimodal pain management, including anesthesia, surgical site infiltration, and postoperative pain medications.\n* Be assessed for pain, opioid use, nausea and vomiting, quadriceps strength, time to first standing, hospital stay length, and patient satisfaction from surgery until discharge.",[82,83],"Pain After Total Knee Arthroplasty","Pain Management",[85,86,87,88,89,90,91],"total knee arthroplasty","distal femoral nerve block","saphenous nerve block","femoral triangle block","postoperative pain","opioid consumption","regional anesthesia","NOT_YET_RECRUITING","2026-06-04",{"date":95,"type":96},"2026-06-05","ACTUAL",{"date":98,"type":76},"2026-05-25",{"date":100,"type":76},"2027-05-25",{"name":5,"class":6},1]