[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100607892":3},{"organization":4,"armGroups":7,"interventions":34,"overallOfficials":39,"centralContacts":39,"locations":39,"responsibleParty":49,"collaborators":39,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":31,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":39,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":39,"overallStatus":72,"whyStopped":39,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":39},{"fullName":5,"class":6},"Shanghai University of Medicine and Health Sciences","OTHER",[8,14,20,25,30],{"label":9,"type":10,"description":11,"interventionNames":12},"Peripheral Magnetic Stimulation (PMS) treatment group","EXPERIMENTAL","Treatment will be administered using a Peripheral Magnetic Stimulation (PMS) device. The intervention involves directing magnetic fields to stimulate specific peripheral nerve regions to regulate neural activity and improve symptoms.",[13],"Device: Peripheral Magnetic Stimulation (PMS)",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham control group","SHAM_COMPARATOR","The placebo group will undergo a treatment process similar to the PMS intervention group, but without actual peripheral magnetic stimulation. The intervention will simulate the PMS treatment process, using a sham device that resembles the PMS device in appearance, but without generating any magnetic or electric field stimulation.",[19],"Device: ham control group receiving PMS intervention",{"label":21,"type":10,"description":22,"interventionNames":23},"Exercise","This exercise prescription includes four phases. First, a 5-minute warm-up (no sandbags\u002Fresistance bands) with walking in place, ankle rotations, and shoulder movements to boost blood flow and prevent injuries. Next, 10-12 minutes of leg strength training: sandbags for half squats (strengthen thighs, hips, knees), calf raises (enhance calf strength and lower limb stability), and resistance bands for standing leg abductions (improve hip\u002Fouter thigh strength\u002Fcoordination). Then, 8-10 minutes of neurocoordination training with sandbags\u002Fresistance bands: marching in place (better leg coordination\u002Fendurance), gait training (improve balance\u002Fneural coordination), and step turns (increase gait flexibility\u002Fbody control). Finally, a 5-minute relaxation with leg\u002Fankle stretches to reduce post-exercise soreness.",[24],"Other: Exercise",{"label":26,"type":10,"description":27,"interventionNames":28},"PMS＋Exercise","Following the completion of PMS, exercise training is randomly conducted.",[29],"Other: PMS＋Exercise",{"label":31,"type":10,"description":32,"interventionNames":33},"PMS","This PMS refers to the peripheral magnetic stimulation administered in Experiment 2, serving to distinguish it from that in Experiment 1.",[13],[35,40,44,47],{"type":36,"name":37,"description":11,"armGroupLabels":38,"otherNames":39},"DEVICE","Peripheral Magnetic Stimulation (PMS)",[31,9],null,{"type":36,"name":41,"description":42,"armGroupLabels":43,"otherNames":39},"ham control group receiving PMS intervention","Identical to the experimental group in all procedures, except that no electrical stimulation is delivered.",[15],{"type":6,"name":21,"description":45,"armGroupLabels":46,"otherNames":39},"See previous sections",[21],{"type":6,"name":26,"description":45,"armGroupLabels":48,"otherNames":39},[26],{"type":50,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":39,"oldOrganization":39},"SPONSOR_INVESTIGATOR","Yuntong Zhang","Graduate Student, School of Rehabilitation, Shanghai University of Medicine & Health Sciences","100607892","combined-exercise-and-pms-impact-on-biopsychosocial-function-in-older-adults-with-schizophrenia-100607892",false,"NCT07194460","Combined Exercise and PMS: Impact on Biopsychosocial Function in Older Adults With Schizophrenia","Effects of Combined Exercise and Peripheral Magnetic Stimulation on Biopsychosocial Functional Impairments in Older Adults With Schizophrenia","\\# Eligibility Criteria\n\n* Inclusion Criteria:\n\n  * Participants must be aged ≥60 years.\n  * Diagnosis of schizophrenia based on the International Classification of Diseases - 10th Edition (ICD-10) or Diagnostic and Statistical Manual of Mental Disorders - 5th Edition (DSM-5).\n  * Diagnosis must be made for ≥6 months, with clinical manifestations of schizophrenia (e.g., hallucinations, delusions, thought disorder, etc.).\n  * No history of severe acute psychiatric episodes or hospitalizations within the last 3 months prior to enrollment.\n  * Symptoms must be controllable, with no reliance on acute psychiatric intervention.\n  * Participants must be able to understand the study's purpose and procedures and provide written informed consent. If the participant is unable to provide full informed consent (e.g., due to severe cognitive impairment), informed consent must be obtained from a legal guardian.\n* Exclusion Criteria:\n\n  * Schizoaffective disorder or bipolar disorder with psychosis.\n  * Elderly individuals with multiple chronic diseases but who still maintain good functional status and quality of life.\n  * Presence of severe cardiovascular diseases, liver or kidney dysfunction, cerebrovascular diseases, or other physical conditions that may affect treatment.\n  * Patients with contraindications to peripheral magnetic stimulation (PMS) treatment or EEG.","ALL","60 Years","80 Years",{"count":64,"type":65},40,"ESTIMATED","INTERVENTIONAL",[68],"NA","This project consists of two randomized parallel - group experiments targeting older adults with schizophrenia, aiming to evaluate the therapeutic effect of Peripheral Magnetic Stimulation (PMS).\n\nExperiment 1 (Efficacy of PMS): During a 4 - week intervention period, participants are randomly assigned to receive active PMS or sham PMS. The primary objective is to determine whether PMS can reduce the clinical symptom burden and improve biopsychosocial functioning compared with sham stimulation through electroencephalogram (EEG) signal acquisition and evaluation. Secondary objectives include the effects on cognition, mood, sleep, and health - related quality of life, as well as safety and tolerability (adverse events monitoring).\n\nExperiment 2 (Comparison of Intervention Effects): The subjects are randomly divided into three groups: exercise combined with PMS group, PMS alone group, and exercise alone group. Each group is arranged by relevant professionals to carry out the corresponding intervention for 4 weeks. The main purpose is to examine the differences in the effects of the three intervention methods (exercise combined with PMS, PMS alone, and exercise alone) in improving patients' conditions, including the impact on exercise - related physical performance, functional mobility, etc. Secondary objectives include the impact on overall function and quality of life, along with safety monitoring.\n\nIn both experiments, outcome indicators are measured from baseline to post - intervention (and, where feasible, short - term follow - up) by assessors who are blinded to group allocation using appropriate tools. It is hypothesized that in Experiment 1, PMS will be superior to sham stimulation; in Experiment 2, the effect of exercise combined with PMS in improving patients' motor and related functions will be better than that of PMS alone or exercise alone, which supports PMS as a scalable auxiliary means for the rehabilitation of this population.",[71],"Schizophrenia Patients","NOT_YET_RECRUITING","2025-09-18",{"date":75,"type":76},"2025-09-26","ACTUAL",{"date":78,"type":65},"2025-09-28",{"date":80,"type":65},"2025-12-05",{"name":51,"class":6}]