[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100532474":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":36,"centralContacts":40,"locations":50,"responsibleParty":68,"collaborators":27,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":27,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":27,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":91,"overallStatus":52,"whyStopped":27,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"Kessler Foundation","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Aerobic Exercise Treatment (AET) combined with Phono-Motor Therapy (PMT)","EXPERIMENTAL","Patients will receive 40, once-daily 2-hour intervention sessions administered 4-5 times per week by trained research assistants. Sessions will begin with a 5-min warm-up, followed by 20 min of aerobic exercise (cycling, 60% heart rate range), and a 5-min cool-down. Participants will rate their perceived effort every 5 minutes and complete a log at the end of each session to characterize their experience. When HR returns to near resting levels (i.e., 5-min after cool-down), participants will undertake the PMT for the remaining 90 min.",[13,14],"Behavioral: Phono-Motor Therapy","Behavioral: Aerobic Exercise Training (AET)",{"label":16,"type":17,"description":18,"interventionNames":19},"Stretching and PMT","ACTIVE_COMPARATOR","Patients will receive 40, once-daily 2-hour intervention sessions administered 4-5 times per week by trained research assistants. Sessions will begin with a 5-min warm-up, followed by 20 min of stretching and a 5-min cool-down. Stretching activities will target the head\u002Fneck, shoulder, elbow\u002Fforearm, hand\u002Fwrist, trunk\u002Fhip, ankle\u002Ffoot. Participants will complete a log at the end of each session to characterize their experience, and within 5 min of completing the last stretching activity, participants will undertake PMT for the remaining 90 min of a given session.",[13,20],"Behavioral: Stretching",[22,28,32],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"BEHAVIORAL","Phono-Motor Therapy","The goal of PMT is to build orthographic and phonological awareness and phonological sequence knowledge. During PMT, participants will complete a series of tasks manipulating minimal sound units (consonants (C) \\& vowels (V)), combining these units into syllables (CVC, CVCC, CCVC) and syllable sequences (real words and readable nonwords). PMT will aim to engage 5 modalities: visual, acoustic, tactile kinesthetic, motor, and orthographic. Multisyllabic stimuli used during treatment will consist of 40 real words and 68 readable nonword letter strings.",[9,16],null,{"type":23,"name":29,"description":30,"armGroupLabels":31,"otherNames":27},"Aerobic Exercise Training (AET)","Stationary ergometer cycling at 60% heart rate range for 20 minutes, plus 5 minutes of warm up and cool down.",[9],{"type":23,"name":33,"description":34,"armGroupLabels":35,"otherNames":27},"Stretching","Light stretching activities targeting the head\u002Fneck, shoulder, elbow\u002Fforearm, hand\u002Fwrist, trunk\u002Fhip, ankle\u002Ffoot.",[16],[37],{"name":38,"affiliation":5,"role":39},"Olga Boukrina","PRINCIPAL_INVESTIGATOR",[41,46],{"name":42,"role":43,"phone":44,"phoneExt":27,"email":45},"Olga Boukrina, PhD","CONTACT","19733243587","oboukrina@kesslerfoundation.org",{"name":47,"role":43,"phone":48,"phoneExt":27,"email":49},"Matthew R Weiner","973-323-3745","mweiner@kesslerfoundation.org",[51],{"facility":5,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"RECRUITING","West Orange","New Jersey","07052","United States","US",{"type":59,"coordinates":60},"Point",[61,62],-74.23904,40.79871,{"lat":62,"lon":61},[65],{"name":66,"role":43,"phone":67,"phoneExt":27,"email":45},"Olga Boukrina, Ph.D.","9733243587",{"type":39,"investigatorFullName":38,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"Research Scientist","100532474","combined-exercise-and-targeted-therapy-for-post-stroke-reading-deficits-100532474",false,"NCT06213272","Combined Exercise and Targeted Therapy for Post-Stroke Reading Deficits","Improving Reading Competence in Aphasia With Combined Aerobic Exercise and Phono-Motor Treatment","Inclusion Criteria:\n\n* fluent and literate in English prior to stroke\n* 1st ever stroke\n* more than 3 months post-stroke\n* post-stroke reading deficits, defined as reading aloud accuracy \\\u003C83% for single words or \\\u003C65% for readable nonwords\n* living within a 50-mile radius from Kessler Foundation.\n\nExclusion Criteria:\n\n* contraindication to MRI\n* prior neurological disease\n* developmental learning or reading disability (i.e., developmental dyslexia)\n* contraindication to exercise\n* concurrent speech and language therapy","ALL","18 Years","85 Years",{"count":81,"type":82},70,"ESTIMATED","INTERVENTIONAL",[85],"NA","The goal of the proposed project is to test the effectiveness of a novel hybrid approach to treatment of reading disorders after stroke, in which exercise training will be used in combination with a targeted reading treatment. This approach is expected to increase cerebral circulation and help to rebuild and strengthen the damaged phonological neural networks. Through this combinatory approach, the study aims to enhance the reading and language improvements seen with existing treatments.",[88,89,90],"Stroke","Aphasia","Reading Disorder",[92,93,94,95,96,97,98],"exercise","stroke","aphasia","reading therapy","phono-motor therapy","aerobic exercise treatment","MRI","2025-05-16",{"date":101,"type":102},"2025-05-21","ACTUAL",{"date":104,"type":102},"2024-04-18",{"date":106,"type":82},"2029-03-01",{"name":5,"class":6},1]