[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621053":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":42,"responsibleParty":58,"collaborators":26,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":62,"sex":68,"minAge":69,"maxAge":26,"enrollmentInfo":70,"targetDuration":26,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":84,"whyStopped":26,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Faculdade de Motricidade Humana","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental Group","EXPERIMENTAL","The experimental group will participate in supervised combined exercise sessions. Additionally, participants will engage in monthly educational sessions.",[13,14],"Behavioral: Exercise","Behavioral: Educational Sessions",{"label":16,"type":17,"description":18,"interventionNames":19},"Control Group","ACTIVE_COMPARATOR","The control group will participate in monthly educational sessions.",[14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Exercise","Participants randomly allocated to the intervention group will engage in a 12-week combined exercise program, supervised by an accredited exercise physiologist. Sessions will comprise an aerobic component and a resistance component. Exercise progression will be individualized based on participants' tolerance.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Educational Sessions","Participants allocated to both intervention and control groups will attend monthly educational sessions on exercise, nutrition, and other essential health-related topics.",[16,9],[32],{"name":33,"affiliation":34,"role":35},"Rúben Francisco, PhD","Polytechnic Institute of Rio Maior","PRINCIPAL_INVESTIGATOR",[37],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Ana Bernardino, PhD Student","CONTACT","+351966636871","afvbernardino@gmail.com",[43],{"facility":5,"status":26,"city":44,"state":26,"zip":26,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Lisbon","Portugal","PT",{"type":48,"coordinates":49},"Point",[50,51],-9.1498,38.72509,{"lat":51,"lon":50},[54],{"name":55,"role":39,"phone":56,"phoneExt":26,"email":57},"Analiza Silva, PhD","+351962903643","analiza@fmh.ulisboa.pt",{"type":59,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100621053","combined-exercise-effects-in-breast-cancer-related-lymphedema-100621053",false,"NCT07365618","Combined Exercise Effects in Breast Cancer-related Lymphedema","The Impact of Combined Exercise on Lymphedema, Body Composition, Muscle Strength, and Quality of Life in Breast Cancer Survivors","LymFit","Inclusion Criteria:\n\n* Aged 18 years or older;\n* Undergone breast cancer surgery with removal of at least one lymph node;\n* Clinical diagnosis of stable unilateral breast cancer-related lymphedema;\n* Willing and able to engage in exercise;\n* Have not participated in a structured exercise program in the previous 6 months;\n* Medical clearance to participate in the study.\n\nExclusion Criteria:\n\n* Unstable lymphedema (therapist-delivered treatment and more than one arm infection requiring antibiotics in the past 3 months);\n* Undergoing radiotherapy or chemotherapy by infusion for breast cancer;\n* Bilateral lymphedema;\n* Primary lymphedema;\n* Uncontrolled heart disease (e.g., uncontrolled coronary heart disease, heart failure, uncontrolled hypertension);\n* Type II diabetes;\n* Psychological disorders (e.g., Alzheimer's, dementia, Parkinson's);\n* Significant physical disabilities;\n* Pregnancy and\u002For breastfeeding;\n* Kidney disease.","FEMALE","18 Years",{"count":71,"type":72},58,"ESTIMATED","INTERVENTIONAL",[75],"NA","Breast cancer-related lymphedema (BCRL) is a common and debilitating condition that affects quality of life, mobility, and well-being. While exercise was once thought to worsen symptoms, current evidence suggests it may improve lymphatic function and symptom management. The LymFit project will test a 12-week combined exercise program (aerobic + resistance) in breast cancer survivors with BCRL compared to usual care.\n\nThis investigation aims to unravel the effects of a combined exercise program on BCRL management. A 12-week randomized controlled trial will be conducted with two arms: a combined exercise intervention (strength + aerobic training) and a control group. The LymFit project primarily aims to assess the effects of 12 weeks of combined exercise on L-Dex in BCRL patients. Secondary objectives include evaluating exercise's effects on i) ECW:ICW ratio (dilution techniques); ii) Body composition (dual-energy X-ray absorptiometry), handgrip strength (dynamometry), cardiorespiratory fitness, quality of life, arm disability, anxiety, depression (questionnaires), and inflammatory profile (blood analysis). The project also examines acute exercise (pre- to post-session) responses on iii) Lymphedema (L-Dex) and iv) Fluid shifts (ultrasound muscle thickness + PV measurement). By integrating clinical outcomes with mechanistic evaluations, this randomized controlled trial seeks to generate evidence-based recommendations for exercise in BCRL management and improve understanding of lymphatic fluid dynamics in this population.",[78],"Breast Cancer-Related Lymphedema",[80,23,81,82,83],"Breast Cancer","Fluid Shifts","Edema","Bioelectrical Impedance Analysis","NOT_YET_RECRUITING","2026-01-19",{"date":87,"type":88},"2026-01-26","ACTUAL",{"date":90,"type":72},"2026-04",{"date":92,"type":72},"2027-12",{"name":5,"class":6},1]