[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641581":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":54,"collaborators":26,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":60,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":26,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":88,"whyStopped":26,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Universidad Europea de Valencia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Combined Manual Therapy and Percutaneous Neuromodulation","EXPERIMENTAL","Participants allocated to the experimental arm will receive a multimodal conservative intervention consisting of manual therapy combined with ultrasound-guided percutaneous neuromodulation. The manual therapy program will include myofascial release techniques, passive accessory joint mobilizations, cervical mobilization when indicated, and median nerve neurodynamic mobilization. Ultrasound-guided percutaneous neuromodulation will be applied to the median nerve using low-frequency electrical stimulation according to a standardized treatment protocol. Participants will receive 12 treatment sessions over a 6-week period.",[13],"Procedure: Combined Manual Therapy and Ultrasound-Guided Percutaneous Neuromodulation",{"label":15,"type":16,"description":17,"interventionNames":18},"Postsurgical Rehabilitation.","ACTIVE_COMPARATOR","Participants allocated to the postsurgical rehabilitation arm will receive a standardized physiotherapy program following carpal tunnel release surgery. The rehabilitation protocol will include transcutaneous electrical nerve stimulation (TENS), active and passive mobilization exercises, strengthening exercises for the wrist and hand, stretching exercises, cryotherapy, and soft tissue techniques as clinically indicated. Participants will receive 18 treatment sessions over a 6-week period.",[19],"Other: Postsurgical Rehabilitation",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Combined Manual Therapy and Ultrasound-Guided Percutaneous Neuromodulation","Participants will receive a multimodal conservative treatment consisting of manual therapy and ultrasound-guided percutaneous neuromodulation. Manual therapy will include myofascial release, passive accessory joint mobilization, cervical mobilization when indicated, and median nerve neurodynamic mobilization. Ultrasound-guided percutaneous neuromodulation will be applied to the median nerve using low-frequency electrical stimulation according to a standardized protocol.",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Postsurgical Rehabilitation","Participants will receive a standardized physiotherapy program following carpal tunnel release surgery, including transcutaneous electrical nerve stimulation (TENS), active and passive mobilization exercises, strengthening exercises, stretching, cryotherapy, and soft tissue techniques as clinically indicated.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Javier Bonastre Férez, PhD","CONTACT","+34644120315","javier.bonastre@universidadeuropea.es",[38],{"facility":39,"status":26,"city":40,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"European University of Valencia","Valencia","46010","Spain","ES",{"type":45,"coordinates":46},"Point",[47,48],-0.37966,39.47391,{"lat":48,"lon":47},[51],{"name":52,"role":34,"phone":53,"phoneExt":26,"email":36},"Javier Bonastre Férez","644120315",{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Dr. Javier Bonastre Férez","Associate Professor","100641581","combined-manual-therapy-and-percutaneous-neuromodulation-for-moderate-carpal-tunnel-syndrome-100641581",false,"NCT07654621","Combined Manual Therapy and Percutaneous Neuromodulation for Moderate Carpal Tunnel Syndrome","Combined Manual Therapy and Percutaneous Neuromodulation Versus Postsurgical Rehabilitation for Moderate Carpal Tunnel Syndrome: Protocol for a Non-Randomized Controlled Trial","MANUCTS","Inclusion Criteria:\n\n* Adults aged 30 to 50 years.\n* Clinical diagnosis of moderate carpal tunnel syndrome confirmed by nerve conduction studies according to the American Association of Electrodiagnostic Medicine criteria.\n* Symptoms persisting for at least 3 months.\n* Ability to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Previous surgery for carpal tunnel syndrome in the affected hand (experimental group only).\n* Severe carpal tunnel syndrome requiring urgent surgical intervention.\n* History of wrist fracture or major upper-limb trauma affecting the study limb.\n* Pregnancy.\n* Diabetes mellitus or other systemic diseases associated with peripheral neuropathy.\n* Cervical radiculopathy or other neurological disorders affecting the upper limb.\n* Rheumatoid arthritis or other inflammatory arthropathies involving the wrist.\n* Previous corticosteroid injection for carpal tunnel syndrome within the last 3 months.\n* Contraindications to percutaneous neuromodulation (e.g., pacemaker, active infection at the treatment site, bleeding disorders, or anticoagulant therapy when considered clinically inappropriate).\n* Inability to comply with the study protocol or follow-up assessments.","ALL","30 Years","50 Years",{"count":70,"type":71},150,"ESTIMATED","INTERVENTIONAL",[74],"NA","Carpal tunnel syndrome (CTS) is the most common peripheral entrapment neuropathy and can cause pain, numbness, tingling, and functional impairment of the hand. Although surgical decompression is considered an effective treatment for moderate CTS, there is increasing interest in conservative therapeutic strategies that may improve symptoms and function while avoiding surgery.\n\nThe aim of this multicenter non-randomized controlled trial is to evaluate the effectiveness of a combined intervention consisting of manual therapy and ultrasound-guided percutaneous neuromodulation compared with conventional postsurgical rehabilitation in patients with moderate CTS.\n\nParticipants allocated to the experimental group will receive a standardized multimodal physiotherapy program including manual therapy techniques and ultrasound-guided percutaneous neuromodulation, whereas participants in the control group will undergo standard rehabilitation following carpal tunnel release surgery. The primary outcome will be symptom severity and functional status assessed with the Boston Carpal Tunnel Questionnaire. Secondary outcomes will include pain intensity, nerve conduction parameters, ultrasound measures, hand strength, patient-reported outcomes, and adverse events.\n\nThe findings of this study are expected to provide evidence regarding the potential role of combined conservative treatment as an alternative therapeutic strategy for patients with moderate carpal tunnel syndrome.",[77],"Carpal Tunnel Syndrome",[77,79,80,81,82,83,84,85,86,87],"Manual Therapy","Percutaneous Neuromodulation","Physical Therapy","Rehabilitation","Median Nerve","Peripheral Neuropathy","Ultrasound-Guided Intervention","Conservative Treatment","Upper Limb","NOT_YET_RECRUITING","2026-06-12",{"date":91,"type":92},"2026-06-17","ACTUAL",{"date":94,"type":71},"2026-07",{"date":96,"type":71},"2028-01",{"name":5,"class":6},1]