[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613566":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":30,"locations":40,"responsibleParty":61,"collaborators":24,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":24,"eligibilityCriteria":68,"healthyVolunteers":65,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":24,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":43,"whyStopped":24,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"State Scientific Centre of Coloproctology, Russian Federation","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"main group","EXPERIMENTAL","Patients of the main group undergo excision of the anal fissure with further relaxation of the internal sphincter with botulinum toxin A (40 units, injection into the internal anal sphincter at 1, 5, 7 and 11 hours, 10 units each)",[13],"Procedure: excision of the anal fissure with further relaxation of the internal sphincter with botulinum toxin A",{"label":15,"type":10,"description":16,"interventionNames":17},"control group","Patients in the control group undergo excision of the anal fissure with further relaxation of the internal sphincter with botulinum toxin A (40 units, injection into the internal anal sphincter at 1, 5, 7 and 11 hours, 10 units each)",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"PROCEDURE","excision of the anal fissure with further relaxation of the internal sphincter with botulinum toxin A","patients undergo excision of the fissure in combination with drug relaxation of the internal sphincter with botulinum toxin type A at a dosage of 40 units of action; an additional injection of platelet-rich plasma is added",[15,9],null,[26],{"name":27,"affiliation":28,"role":29},"Sergey A. Frolov, Ph.D","State Scientific Centre of Coloproctology, Russian Federation (SSCCRussia)","PRINCIPAL_INVESTIGATOR",[31,36],{"name":32,"role":33,"phone":34,"phoneExt":24,"email":35},"Evgeny E. Zharkov, MD","CONTACT","+79039689739","drzharkov@mail.ru",{"name":37,"role":33,"phone":38,"phoneExt":24,"email":39},"Ekaterina Yu. Lebedeva","+79779558920","katerina.lebedeva.1997@mail.ru",[41],{"facility":42,"status":43,"city":44,"state":24,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"SSCCRussia","RECRUITING","Moscow","123423","Russia","RU",{"type":49,"coordinates":50},"Point",[51,52],37.61781,55.75204,{"lat":52,"lon":51},[55,59],{"name":56,"role":33,"phone":34,"phoneExt":57,"email":58},"Sergey A Frolov, phd","89039689739","DrZharkow@mail.ru",{"name":60,"role":33,"phone":34,"phoneExt":34,"email":35},"Evgeny E Zharkov",{"type":62,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100613566","combined-method-of-surgical-treatment-of-anal-fissure-100613566",false,"NCT07268261","Combined Method of Surgical Treatment of Anal Fissure","Inclusion Criteria:\n\n* • Patients with chronic anal fissure with spasm of anal sphincter\n\nExclusion Criteria:\n\n* • Inflammatory diseases of the colon\n\n  * Pectenosis\n  * Previous surgical interventions on the anal canal\n  * IV grade internal and external hemorrhoids\n  * Rectal fistula\n  * Severe somatic diseases at the decompensation stage\n  * Pregnancy and lactation\n  * Anal sphincter insufficiency\n  * Chronic paraproctitis\n  * Individual intolerance and hypersensitivity to botulinum toxin\n  * Myasthenia gravis and myasthenic syndromes\n  * History of allergic reaction to anticoagulants.\n  * Blood diseases (thrombocytopenia, splenomegaly, etc.)","ALL","18 Years","70 Years",{"count":73,"type":74},122,"ESTIMATED","INTERVENTIONAL",[77],"NA","The purpose of this study is to improve treatment outcomes for patients with chronic anal fissure.",[80],"Chronic Anal Fissure",[82,83,84,85,86,87,88],"Fissure in Ano","Anal fissure","botulinum toxin A","Chronic anal pain","Fecal incontinence","Spasm of the internal sphincter","Anal sphincter insufficiency","2025-12-03",{"date":91,"type":92},"2025-12-05","ACTUAL",{"date":94,"type":92},"2023-09-01",{"date":96,"type":74},"2026-09-01",{"name":5,"class":6},1]