[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636871":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":25,"responsibleParty":42,"collaborators":10,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":10,"eligibilityCriteria":52,"healthyVolunteers":48,"sex":53,"minAge":54,"maxAge":10,"enrollmentInfo":55,"targetDuration":10,"studyType":58,"phases":10,"briefSummary":59,"conditions":60,"keywords":65,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Istanbul University - Cerrahpasa","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Successful Weaning",null,"Patients who maintain respiratory stability without reintubation, rescue ventilation, or death during both the initial 48 hours post-extubation and the 7-day follow-up period.",{"label":13,"type":10,"description":14,"interventionNames":10},"Failed Weaning","Patients who experience reintubation, need for rescue ventilation, or mortality either within the first 48 hours post-extubation or during the 7-day monitoring phase.",[16,21],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"mahmut baran kasisari, medical doctor","CONTACT","+905072225254","barankasisari@hotmail.com",{"name":22,"role":18,"phone":23,"phoneExt":10,"email":24},"tugba yesilyurt dogu, medical doctor","+905535150847","tugbaayesilyurt@gmail.com",[26],{"facility":27,"status":28,"city":29,"state":29,"zip":30,"country":31,"countryCode":10,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"Basaksehir Cam and Sakura City Hospital","RECRUITING","Istanbul","34480","Turkey (Türkiye)",{"type":33,"coordinates":34},"Point",[35,36],28.94966,41.01384,{"lat":36,"lon":35},[39],{"name":40,"role":18,"phone":41,"phoneExt":10,"email":20},"mahmut baran kasisari, Medical Doctor","905072225254",{"type":43,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Mahmut Baran Kasisari","Specialist Physician","100636871","combined-predictive-value-of-rsbi-and-cally-index-in-predicting-weaning-success-in-icu-patients-100636871",false,"NCT07571317","Combined Predictive Value of RSBI and CALLY Index in Predicting Weaning Success in ICU Patients","Combined Predictive Value of Rapid Shallow Breathing Index (RSBI) and CRP-Albumin-Lymphocyte (CALLY) Indices in Predicting the Success of Weaning From Mechanical Ventilation in Intensive Care Patients: A Prospective Observational Study","Inclusion Criteria:\n\n* Patients aged 18 years and older\n* Patients who have received invasive mechanical ventilation for at least 24 hours in the general intensive care unit.\n\nPatients who meet standard clinical weaning criteria (e.g., hemodynamic stability with minimal or no vasopressor support, adequate cough reflex, absence of excessive airway secretions).\n\nPatients deemed ready for a Spontaneous Breathing Trial by the attending physician.\n\nExclusion Criteria:\n\n* Patients under the age of 18.\n* Patients with a known or detected pregnancy.\n* Patients with a diagnosis of malignancy.\n* Patients with neuromuscular diseases that could impair respiratory effort or muscle strength assessments (e.g., Myasthenia Gravis, Amyotrophic Lateral Sclerosis, Guillain-Barré syndrome).","ALL","18 Years",{"count":56,"type":57},105,"ESTIMATED","OBSERVATIONAL","The primary objective of this prospective observational study is to evaluate the effectiveness of combining the Rapid Shallow Breathing Index (RSBI) and CRP-Albumin-Lymphocyte (CALLY) index to predict weaning success in adult patients within the intensive care unit. While weaning from mechanical ventilation is a critical clinical step, existing physiological metrics like RSBI do not fully capture a patient's inflammatory or nutritional status. This research introduces the CALLY index calculated as the ratio of the patient's immuno-nutritional reserve (Albumin and Lymphocytes) to systemic inflammation (CRP) as a complementary metabolic marker. By tracking approximately 105 participants at Basaksehir Cam and Sakura City Hospital, the study monitors weaning success over both a 48 hour and a 7 day period to identify both immediate and late phase extubation failures. The ultimate goal is to provide a more holistic prediction model that potentially reduces re-intubation rates and improves clinical outcomes by accurately identifying the optimal time for ventilator removal.",[61,62,63,64],"Critical Illness","Respiratory Insufficiency","Ventilator Weaning","Weaning Failure of Mechanical Ventilation",[66,67,68,69],"mechanical ventilation","ventilator weaning","Systemic Inflammation","CRP-Albumin-Lymphocyte Ratio","2026-05-06",{"date":72,"type":73},"2026-05-11","ACTUAL",{"date":75,"type":57},"2026-05-04",{"date":77,"type":57},"2026-07-31",{"name":5,"class":6},1]