[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100589773":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":17,"centralContacts":21,"locations":7,"responsibleParty":26,"collaborators":7,"id":28,"slug":29,"hasResults":30,"nctId":31,"briefTitle":32,"officialTitle":33,"acronym":7,"eligibilityCriteria":34,"healthyVolunteers":30,"sex":35,"minAge":36,"maxAge":7,"enrollmentInfo":37,"targetDuration":7,"studyType":40,"phases":7,"briefSummary":41,"conditions":42,"keywords":44,"overallStatus":47,"whyStopped":7,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":7},{"fullName":5,"class":6},"National Taiwan University Hospital","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":13},"DIAGNOSTIC_TEST","Electrical impedance tomography","* Electrical impedance tomography (EIT)：Assessing pulmonary function in chronic lung diseases.\n* Lung ultrasound：Assessing diaphragm atrophy in mechanically ventilated patients.\n* Esophageal pressure：The work of breathing, or the energy required by respiratory muscles to meet ventilatory demands, can be directly evaluated by esophageal pressure\n* Oxygen consumption：Indirectly evaluated by measuring oxygen consumption (V̇O2) during mechanical ventilation The oxygen cost of breathing, reflected the increase in V̇O2 when transitioning from mechanical ventilation to spontaneous breathing, has been shown to predict weaning outcomes.",[14,15,16],"Lung ultrasound","Esophageal pressure","Oxygen consumption",[18],{"name":19,"affiliation":5,"role":20},"Yao-Wen Kuo","PRINCIPAL_INVESTIGATOR",[22],{"name":19,"role":23,"phone":24,"phoneExt":7,"email":25},"CONTACT","886+972651821","kyw@ntu.edu.tw",{"type":27,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100589773","combining-electrical-impedance-tomography-and-thoracic-ultrasound-toinvestigate-dynamic-changes-100589773",false,"NCT06958770","Combining Electrical Impedance Tomography and Thoracic Ultrasound Toinvestigate Dynamic Changes","Combining Electrical Impedance Tomography and Thoracic Ultrasound to Investigate Dynamic Changes of Respiratory Effort, and Regional & End-expiratory Lung Volume in Mechanically Ventilated Patients.","Inclusion Criteria:\n\n* Adult \\>18 y\u002Fo.\n* Patient intubated and receiving mechanical ventilation \\> 24 hours.\n* Admitted into ICU, diagnosed as moderate or severe ARDS (ICD-10-CM: J80) according to Berlin definition.\n\nExclusion Criteria:\n\n* Presence of Implanted Electronic Devices (pacemakers, implantable cardioverter-defibrillators).\n* Pregnancy.\n* No consent\u002Finability to obtain consent and appropriate legal representative not available.","ALL","18 Years",{"count":38,"type":39},50,"ESTIMATED","OBSERVATIONAL","1. To evaluate the dynamic changes of lung ultrasound during electrical impedance tomography (EIT) PEEP titration and across the first week of ARDS.\n2. To asses respiratory effort by diaphragmatic function, esophageal pressure, and EIT (Pendelluft phenomenon), and hyperinflammatory biomarkers, to predict P-SILI.\n3. To develop predictive models for weaning success based on integrated EELI and thoracic ultrasound.",[43],"ARDS (Moderate or Severe)",[45,46],"Chest ultrasound","electrical impedance tomography","NOT_YET_RECRUITING","2025-04-27",{"date":50,"type":51},"2025-05-06","ACTUAL",{"date":53,"type":39},"2025-05-19",{"date":55,"type":39},"2028-12-31",{"name":5,"class":6}]