[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577516":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":30,"centralContacts":35,"locations":30,"responsibleParty":41,"collaborators":30,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":30,"eligibilityCriteria":51,"healthyVolunteers":47,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":30,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":30,"overallStatus":66,"whyStopped":30,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":30},{"fullName":5,"class":6},"Assiut University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Ipsilesional high frequency rTMS combined with physiotherapy","ACTIVE_COMPARATOR","rTMS Protocol:\n\nStimulation delivered to the hand area of the ipsilesional primary motor cortex (M1).\n\nFrequency: 3 Hz.\n\nStimulation: 2 seconds per train, 37 trains per session.\n\nTotal pulses: 750 per session at 130% of the resting motor threshold (RMT).\n\nPhysiotherapy:\n\nPatients receive standard physiotherapy sessions.",[13],"Device: Ipsilesional high frequency rTMS combined with physiotherapy",{"label":15,"type":10,"description":16,"interventionNames":17},"Contralesional Continuous Burst Theta rTMS (cTBS) + Physiotherapy","rTMS Protocol:\n\nStimulation delivered to the contralesional primary motor cortex (M1).\n\nProtocol: Continuous bursts of 3 stimuli at 50 Hz, repeated at 5 bursts per second.\n\nDuration: 40 seconds per session.\n\nStimulation intensity: 70% of RMT with a biphasic TMS-induced current at a 45° angle to the midline.\n\nPhysiotherapy:\n\nPatients receive standard physiotherapy sessions.",[18],"Device: Contralesional Continuous Burst Theta rTMS (cTBS) + Physiotherapy",{"label":20,"type":21,"description":22,"interventionNames":23},"Sham rTMS + Physiotherapy","SHAM_COMPARATOR","Patients receive a sham stimulation designed to mimic rTMS without delivering active magnetic pulses.\n\nThis maintains blinding for participants and investigators.\n\nPhysiotherapy:\n\nPatients receive standard physiotherapy sessions.",[24],"Device: Sham rTMS + Physiotherapy",[26,31,33],{"type":27,"name":9,"description":28,"armGroupLabels":29,"otherNames":30},"DEVICE","As mentioned in details in arms description.",[9],null,{"type":27,"name":15,"description":28,"armGroupLabels":32,"otherNames":30},[15],{"type":27,"name":20,"description":28,"armGroupLabels":34,"otherNames":30},[20],[36],{"name":37,"role":38,"phone":39,"phoneExt":30,"email":40},"Mohammad Ahmad Korayem, Assistant lecturer","CONTACT","+201021478054","Mohammadkorayem@aun.edu.eg",{"type":42,"investigatorFullName":43,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Mohammad Ahmad Mohammad Korayem","Assisstant lecturer","100577516","comparative-effectiveness-of-ipsilesional-high-frequency-rtms-contralesional-continuous-burst-theta-rtms-and-sham-rtms-each-combined-with-physiotherapy-in-subacute-ischemic-stroke-upper-limb-recovery--clinical-neurophysiological-and-radiological-100577516",false,"NCT06799312","Comparative Effectiveness of Ipsilesional High-frequency rTMS, Contralesional Continuous Burst Theta rTMS, and Sham rTMS, Each Combined With Physiotherapy, in Subacute Ischemic Stroke Upper Limb Recovery : Clinical, Neurophysiological and Radiological","Comparative Effectiveness of Ipsilesional High-frequency rTMS, Contralesional Continuous Burst Theta rTMS, and Sham rTMS, Each Combined With Physiotherapy, in Subacute Ischemic Stroke Upper Limb Recovery : Clinical, Neurophysiological and Radiological: A Double-blinded Randomized Clinical Trial","Inclusion Criteria:\n\n* First-ever ischemic stroke, confirmed by imaging.\n* Stroke affecting the non-dominant hemisphere (cortical or subcortical) within the middle cerebral artery (MCA) territory.\n* Acute to subacute stage of stroke (time since onset: 48 hours to 2 weeks).\n* Ability to comply with the study protocol and interventions.\n\nExclusion Criteria:\n\n* Hemorrhagic stroke or bilateral stroke.\n* Severe cognitive impairment, defined as a Montreal Cognitive Assessment (MoCA) score \\\u003C 10.\n* Contraindications to TMS, such as: History of epilepsy, Metallic implants in the head, Other contraindications based on TMS safety guidelines.\n* Comorbid conditions that limit participation in rehabilitation.\n* Severe neglect or aphasia that would impede participation in therapy.","ALL","40 Years","70 Years",{"count":56,"type":57},90,"ESTIMATED","INTERVENTIONAL",[60],"NA","To compare the efficacy of lesional high-frequency rTMS, contralesional cTBS, and sham stimulation in improving motor and cognitive recovery in post-stroke patients undergoing physiotherapy.",[63,64,65],"Repetitive Transcranial Magnetic Stimulation","Stroke","Functional MRI","NOT_YET_RECRUITING","2025-03-02",{"date":69,"type":70},"2025-03-05","ACTUAL",{"date":72,"type":57},"2025-03-15",{"date":74,"type":57},"2026-12-31",{"name":5,"class":6}]