[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628533":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":40,"responsibleParty":58,"collaborators":62,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":26,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":99,"whyStopped":26,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Liverpool John Moores University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Mediterranean-style diet","ACTIVE_COMPARATOR","Participants will be provided with an isocaloric diet rich in fruits, vegetables, whole grains, legumes, nuts, olive oil, and fish, consistent with and optimised to reflect a traditional Mediterranean dietary pattern. The diet will include moderate amounts of poultry and dairy products and limited amounts of red and processed meat, refined carbohydrates, and added sugars.",[13],"Dietary Supplement: Mediterranean Diet",{"label":15,"type":16,"description":17,"interventionNames":18},"Carnivore-style diet","EXPERIMENTAL","Participants will be provided with an isocaloric diet consisting primarily of animal-based products, including red meat, poultry, and limited amounts of dairy products. The diet will exclude plant-based foods, such as fruits, vegetables, grains, legumes, nuts, and seeds to reflect a traditional Carnivore-style dietary pattern.",[19],"Dietary Supplement: Carnivore Diet",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Carnivore Diet","The intervention diet will consist of isocaloric consumption of exclusively of animal-based products, including red meat, poultry, and limited amounts of dairy products for 3 weeks. The diet will exclude plant-based foods, such as fruits, vegetables, grains, legumes, nuts, and seeds to reflect a traditional Carnivore-style dietary pattern.",[15],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Mediterranean Diet","The intervention diet will consist of isocaloric consumption of foods typical of a traditional Mediterranean dietary pattern, including fruits, vegetables, whole grains, legumes, nuts, olive oil, and fish, for a period of 3 weeks. The diet will include moderate amounts of poultry and dairy products and limited amounts of red and processed meat, refined carbohydrates, and added sugars.",[9],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Megan Wilson, BSc Nutrition","CONTACT","+447362317430","M.L.Wilson@ljmu.ac.uk",{"name":38,"role":34,"phone":26,"phoneExt":26,"email":39},"Dr Richie Kirwan","R.P.Kirwan@ljmu.ac.uk",[41],{"facility":42,"status":26,"city":43,"state":26,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Tom Reilly Building, Liverpool John Moores University","Liverpool","L3 3AF","United Kingdom","UK",{"type":48,"coordinates":49},"Point",[50,51],-2.97794,53.41058,{"lat":51,"lon":50},[54,57],{"name":55,"role":34,"phone":56,"phoneExt":26,"email":36},"Megan Megan Wilson","447362317430",{"name":38,"role":34,"phone":26,"phoneExt":26,"email":39},{"type":59,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Megan Wilson","Principal Investigator",[63,65],{"name":64,"class":6},"Wihuri Research Institute",{"name":66,"class":6},"University of Helsinki","100628533","comparative-effects-of-carnivore-and-mediterranean-style-diets-on-ldl-aggregation-and-cardiometabolic-health-100628533",false,"NCT07462871","Comparative Effects of Carnivore and Mediterranean-style Diets on LDL Aggregation and Cardiometabolic Health","Comparative Effects of Carnivore and Mediterranean-style Diets on LDL Aggregation Susceptibility and Cardiometabolic Health","MEDIVORE","Inclusion Criteria:\n\n* Male or female\n* 30-60 years of age\n* Elevated LDL cholesterol (LDL \\>3mmol\u002FL and\u002For non-HDL cholesterol \\> 4mmol\u002FL)\n* Not following any specific diet for health reasons.\n* Not currently taking lipid-lowering medications or supplements that may interfere with LDL levels.\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding.\n* Known food allergies or intolerances.\n* Previous history of disordered eating.\n* Currently taking cholesterol-lowering medication or supplements.",true,"ALL","30 Years","60 Years",{"count":80,"type":81},30,"ESTIMATED","INTERVENTIONAL",[84],"NA","The goal of this clinical trial is to learn whether following a Mediterranean-style diet or a Carnivore-style diet can improve heart and metabolic health in men and women aged 30-60 years with high LDL cholesterol.\n\nThe main questions it aims to answer are:\n\n1. Does following a Mediterranean or Carnivore diet change how easily LDL cholesterol particles clump together (LDL aggregation susceptibility)?\n2. Do these two diets have different effects on other measures of heart and metabolic health, such as blood fats, blood vessel function, and overall wellbeing?\n\nResearchers will compare people who follow the Mediterranean-style diet with those who follow the Carnivore-style diet to see which diet produces more beneficial changes in cholesterol and heart health markers.\n\nParticipants will:\n\n* Attend three visits at Liverpool John Moores University for screening and data collection.\n* Be randomly assigned to follow either the Mediterranean or Carnivore diet for 3 weeks, matched for calories and protein.\n* Provide fasting blood, urine, and stool samples before and after the diet period.\n* Complete non-invasive cardiovascular tests to measure blood vessel and heart function.\n* Take part in a short interview and complete questionnaires about their experience of following the diet.",[87,88,89],"Atherosclerosis Cardiovascular Disease","Metabolic Syndrome","Dyslipidaemia",[91,92,93,94,95,96,97,98],"Atherosclerosis","ASCVD","Diet, carbohydrate-restricted","Ketogenic diet","LDL aggregation","Low-density lipoproteins","Lipoproteins","Lipid metabolism","NOT_YET_RECRUITING","2026-03-11",{"date":102,"type":103},"2026-03-13","ACTUAL",{"date":105,"type":81},"2026-06",{"date":107,"type":81},"2027-06",{"name":5,"class":6},1]