[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638862":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":32,"locations":42,"responsibleParty":64,"collaborators":24,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":71,"acronym":24,"eligibilityCriteria":72,"healthyVolunteers":69,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":24,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":91,"whyStopped":24,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Combined Military Hospital Abbottabad","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Mandelic Acid Peel","ACTIVE_COMPARATOR","Participants will receive mandelic acid chemical peels every two weeks for six sessions over 12 weeks.",[13],"Procedure: Mandelic Acid Peel",{"label":15,"type":10,"description":16,"interventionNames":17},"Intralesional Tranexamic Acid","Participants will receive intradermal tranexamic acid injections every two weeks for six sessions over 12 weeks.",[18],"Procedure: Intralesional Tranexamic Acid",[20,25],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"PROCEDURE","After degreasing the face, mandelic acid solution will be applied for 5-7 minutes and then neutralized. Sessions will be repeated every two weeks for six sessions.",[9],null,{"type":21,"name":15,"description":26,"armGroupLabels":27,"otherNames":24},"Tranexamic acid will be injected intradermally at 1-cm intervals over melasma patches using a 30-gauge insulin syringe every two weeks for six sessions.",[15],[29],{"name":30,"affiliation":5,"role":31},"Ali Amar, MBBS, FCPS(dermatology), CHPE","STUDY_CHAIR",[33,38],{"name":34,"role":35,"phone":36,"phoneExt":24,"email":37},"Shapara Shakeel, MBBS, FCPS-resident derm","CONTACT","+923489081830","shaparashakil@gmail.com",{"name":39,"role":35,"phone":40,"phoneExt":24,"email":41},"Ovais Faizi, MBBS, FCPS(Internal Medicine)","+923134422922","ovaisfaizi@yahoo.com",[43],{"facility":44,"status":24,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Combined Military Hospital, Abbottabad","Abbottabad","KPK","22010","Pakistan","PK",{"type":51,"coordinates":52},"Point",[53,54],73.21168,34.1463,{"lat":54,"lon":53},[57,61,62],{"name":58,"role":35,"phone":59,"phoneExt":24,"email":60},"Ali Amar, MBBS, FCPS(Dermatology), CHPE","+923215625426","docaliamar@gmail.com",{"name":24,"role":35,"phone":24,"phoneExt":24,"email":37},{"name":34,"role":63,"phone":24,"phoneExt":24,"email":24},"PRINCIPAL_INVESTIGATOR",{"type":63,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Dr Shapara Shakeel","Resident Dermatologist","100638862","comparative-efficacy-of-intralesional-tranexamic-acid-versus-mandelic-acid-peel-in-the-treatment-of-melasma-100638862",false,"NCT07604844","Comparative Efficacy of Intralesional Tranexamic Acid Versus Mandelic Acid Peel in the Treatment of Melasma","Inclusion Criteria:\n\nAge 18-45 years. Clinical diagnosis of facial melasma. Fitzpatrick skin phototypes III-V. Disease duration of at least 3 months.\n\nExclusion Criteria:\n\nPregnancy or lactation. Known hypersensitivity to tranexamic acid or mandelic acid. Active facial dermatoses or infection. Personal or family history of thromboembolic disease. Coagulation disorders. Systemic retinoid use within 6 months. Oral contraceptive or hormone replacement therapy within 6 months. Use of topical or systemic depigmenting agents within 4 weeks. History of keloid tendency.","ALL","18 Years","45 Years",{"count":77,"type":78},120,"ESTIMATED","INTERVENTIONAL",[81],"NA","Melasma is a chronic acquired disorder of facial hyperpigmentation that significantly affects quality of life. Both intralesional tranexamic acid and mandelic acid chemical peels are effective treatment options with favorable safety profiles in darker skin types. However, comparative evidence in South Asian populations is limited. This study aims to compare the efficacy, safety, quality of life outcomes, and patient satisfaction of intralesional tranexamic acid versus mandelic acid peel in patients with facial melasma treated at Combined Military Hospital Abbottabad.",[84],"Melasma",[84,86,87,88,89,90,48],"Tranexamic Acid","Mandelic Acid","Chemical Peel","Hyperpigmentation","MELASQoL","NOT_YET_RECRUITING","2026-05-24",{"date":94,"type":95},"2026-05-28","ACTUAL",{"date":97,"type":78},"2026-05",{"date":99,"type":78},"2026-10",{"name":5,"class":6},1]