[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601884":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":25,"responsibleParty":36,"collaborators":25,"id":40,"slug":41,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":25,"eligibilityCriteria":46,"healthyVolunteers":47,"sex":48,"minAge":49,"maxAge":25,"enrollmentInfo":50,"targetDuration":25,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":65,"whyStopped":25,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":25},{"fullName":5,"class":6},"Oman Medical Speciality Board","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Parecoxib","ACTIVE_COMPARATOR","Patients in this group will receive IV parecoxib 40 mg (the standard full dose for an adult) diluted to a total volume of 5 mL with normal saline. The study drug will be injected into the IV cannula on the dorsum of hand \\*\\*with a tourniquet applied\\*\\* on the mid-arm (upper forearm) to occlude venous return. The tourniquet (elastic band) pressure will be just enough to distend veins (similar to when drawing blood) but not cause excessive discomfort. The parecoxib solution will be given over \\~5-10 seconds. The tourniquet will remain in place for \\*\\*2 minutes\\*\\* after injection, then released. This technique of venous occlusion is borrowed from Bier block and previous studies, aiming to localize the drug in the vein for a short period to maximize local effect. then propofol will be administered.",[13],"Drug: Parecoxib 40mg",{"label":15,"type":10,"description":16,"interventionNames":17},"Lidocaine","Patients in this group will receive IV lidocaine at a dose of 0.5 mg\u002Fkg (ideal body weight) up to a maximum of 50 mg, diluted to a total of 5 mL. The lidocaine will be given into the hand IV cannula \\*\\*with a tourniquet\\*\\* on the forearm, It will likewise dwell for 2 minutes under occlusion before tourniquet release. This tourniquet method for lidocaine is known to significantly improve its efficacy in preventing injection pain",[18],"Drug: Lidocaine, a local anaesthetic.",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Lidocaine, a local anaesthetic.","it will be given as a pretreatment prior to injection of propofol, with a tourniquet applied.",[15],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Parecoxib 40mg","atients in this group will receive IV parecoxib 40 mg (the standard full dose for an adult) diluted to a total volume of 5 mL with normal saline.",[9],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Mohammed Alrashdi, Mb BCH BAO","CONTACT","+96896686858","r24005@resident.omsb.org",{"type":37,"investigatorFullName":38,"investigatorTitle":39,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Mohammed Hamood Alrashdi","Resident Doctor","100601884","comparative-efficacy-of-iv-parecoxib-vs-lidocaine-in-reducing-propofol-injection-pain-100601884",false,"NCT07116304","Comparative Efficacy of IV Parecoxib vs Lidocaine in Reducing Propofol Injection Pain","Comparative Efficacy of Intravenous Parecoxib Versus Lidocaine in Reducing Propofol Injection Pain: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult patients, ≥18 years\n* ASA grading I-II\n* Patients undergoing elective surgical procedures across all surgical specialties.\n* Can speak Arabic or English\n\nExclusion Criteria:\n\n* Difficulty in communicating.\n* Liver Cirrhosis patients\n* Renal failure or creatinine clearance (CrCl) ≤ 10umol\u002FL,\n* Known Lidocaine, parecoxib and\u002For propofol allergy.\n* patients who are not using propofol for an induction.\n* Any known contraindication to propofol, parecoxib or lidocaine. (this will include renal failure or cirrhosis of the liver as noted above)\n* Patients refusing to be involved in the study.\n* ASA(American society of anaesthesia) grading 3-6.\n* Any patient that IV access cannot be established in the dorsum of the hand.\n* Pregnant women.\n* Patients with chronic pain disorders.\n* Patients who received any form of analgesia within the last hour.",true,"ALL","18 Years",{"count":51,"type":52},30,"ESTIMATED","INTERVENTIONAL",[55],"NA","Propofol is the most popular IV anaesthetic agent used for induction, however one of its known side effects is causing pain on injection, the gold standard method in preventing this pain is using lidocaine prior to injecting propofol. multiple drugs have been investigated to reduce the aforementioned pain, however there has been no study comparing lidocaine to parecoxib, an NSAID.",[58],"Preventing Propofol Pain on Injection",[60,61,62,63,64],"randomised controlled trial","parecoxib","propofol","NSAIDs","pain on injection","NOT_YET_RECRUITING","2025-08-08",{"date":68,"type":69},"2025-08-11","ACTUAL",{"date":71,"type":52},"2025-08-01",{"date":73,"type":52},"2026-12-30",{"name":5,"class":6}]