[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100544720":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":38,"centralContacts":45,"locations":57,"responsibleParty":76,"collaborators":55,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":55,"eligibilityCriteria":84,"healthyVolunteers":85,"sex":86,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":55,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":55,"overallStatus":60,"whyStopped":55,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"Suez Canal University","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Mineral Trioxide Aggregate","ACTIVE_COMPARATOR","is a powder that consist of Calcium oxide, silicone dioxide, aluminum oxide, bismuth oxide, purified water. It is a bactericidal dressing material, promotes pulp healing, and does so without producing inflammation and promotes dentin bridge formation.",[13],"Drug: Mineral trioxide aggregate (dressing material)",{"label":15,"type":16,"description":17,"interventionNames":18},"Melatonin","EXPERIMENTAL","(N-acetyl-5-methoxy-tryptamine) is a pleiotropic hormone synthesized in the pineal gland that has important chronobiotic properties. there is a Melatonin drug (powder) that proved to play an essential role in the regulation of bone growth (bone regeneration) and it may promote osteoblast differentiation, and stimulates mineralized matrix formation",[19],"Drug: Melatonin (dressing material)",{"label":21,"type":16,"description":22,"interventionNames":23},"Mineral Trioxide and Melatonin","Mixture of the two materials' powders.",[13,19],[25,32],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","Mineral trioxide aggregate (dressing material)","MTA (Angulus Industrial de productus Odontologists S\u002Fa, Brazil) that applied on dental pulp for tissue regeneration",[9,21],[31],"MTA",{"type":26,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"Melatonin (dressing material)","melatonin powder 250mg (sigma, Aldrich)- white powder mixing with saline and applied on dental pulp",[15,21],[37],"N-acetyl-5-methoxy-tryptamine",[39,43],{"name":40,"affiliation":41,"role":42},"Gihan GED El-Desouky, Professor","Professor","PRINCIPAL_INVESTIGATOR",{"name":44,"affiliation":41,"role":42},"Ghada AH Elbaz, Professor",[46,52],{"name":47,"role":48,"phone":49,"phoneExt":50,"email":51},"Mennatallah Hesham El shaabany, doctorate student","CONTACT","01012906460","01005359111","menna.hesham@dent.suez.edu.eg",{"name":53,"role":48,"phone":54,"phoneExt":55,"email":56},"Asmaa Ali Abo El-Soud, Associate professor","01220989854",null,"asmaa_ali@dent.suez.edu.eg",[58],{"facility":59,"status":60,"city":61,"state":55,"zip":62,"country":63,"countryCode":64,"cosmosGeoPoint":65,"geoPoint":70,"contacts":71},"Faculty of Medicine, Suez canal university","RECRUITING","Ismailia","41522","Egypt","EG",{"type":66,"coordinates":67},"Point",[68,69],32.27225,30.60427,{"lat":69,"lon":68},[72],{"name":73,"role":48,"phone":74,"phoneExt":55,"email":75},"Ismail Dahshan, PHD","01012715799","dahshan1633@gmail.com",{"type":77,"investigatorFullName":55,"investigatorTitle":55,"investigatorAffiliation":55,"oldNameTitle":55,"oldOrganization":55},"SPONSOR","100544720","comparative-evaluation-of-melatonin-versus-mta-on-vital-pulp-therapy-in-young-permanent-first-molars-an-in-vivo-study-100544720",false,"NCT06372561","Comparative Evaluation of Melatonin Versus MTA on Vital Pulp Therapy in Young Permanent First Molars: An in Vivo Study","Comparative Evaluation of Melatonin Versus Mineral Trioxide Aggregate on Vital Pulp Therapy in Young Permanent First Molars: An in Vivo Study","Inclusion Criteria:\n\n* 1- Apparently healthy and medically free children. 2- Their age ranges from 6-8 years. 3- Both boys and girls will be included. 4- Children should have mandibular permanent first molars with the following clinical and radiographic criteria. 4.1Restorable young permanent first molars. 4.2Absence of clinical evidence of pulp degeneration:\n* No history of spontaneous pain, history of night pain or pain that not relieved by analgesics.\n* No pain on percussion.\n* No mobility.\n* Absence of abscess, purulent sinus or soft tissue edema.\n* Bleeding should stop within 5 minutes after the amputated pulp stumps.\n\nExclusion Criteria:\n\n* Internal root resorption.\n* External root resorption.\n* Inter radicular or periapical bone destruction (radiolucency)\n* A deep carious lesion radiologically that approaches the pulp",true,"ALL","6 Years","8 Years",{"count":90,"type":91},45,"ESTIMATED","INTERVENTIONAL",[94],"NA","The process of dental caries is dynamic and can be either reversible or irreversible depending on the balance between protective and pathologic factors in the oral cavity. Untreated dental caries causes pulpal injury, inflammation, and necrosis. Melatonin plays an essential role in the regulation of bone growth. The actions that melatonin exerts on odontoblasts may be similar to its action on osteoblasts.",[97,98],"Dental Caries in Children","Vital Pulp Therapy","2024-08-01",{"date":101,"type":102},"2024-08-02","ACTUAL",{"date":104,"type":102},"2023-05-20",{"date":106,"type":91},"2024-10-02",{"name":5,"class":6},1]