[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100372178":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":37,"centralContacts":41,"locations":46,"responsibleParty":76,"collaborators":10,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":10,"eligibilityCriteria":85,"healthyVolunteers":81,"sex":86,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":10,"studyType":92,"phases":10,"briefSummary":93,"conditions":94,"keywords":10,"overallStatus":49,"whyStopped":10,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"The Cleveland Clinic","OTHER",[8,15,19,23],{"label":9,"type":10,"description":11,"interventionNames":12},"Mitral Valve Regurgitation",null,"Patients with moderate or severe (3+ or 4+) mitral valve regurgitation on the basis of prior known clinical history or clinical exam.",[13,14],"Diagnostic Test: MRI with strain measurement","Diagnostic Test: Echocardiography",{"label":16,"type":10,"description":17,"interventionNames":18},"Aortic Valve Regurgitation","Patients with moderate or severe (3+ or 4+) aortic valve regurgitation on the basis of prior known clinical history or clinical exam.",[13,14],{"label":20,"type":10,"description":21,"interventionNames":22},"Aortic Stenosis","Patients with moderate or severe (3+ or 4+) aortic stenosis on the basis of prior known clinical history or clinical exam.",[13,14],{"label":24,"type":10,"description":25,"interventionNames":26},"Patients referred for CRT Implantation","Patients who meet clinical guideline criteria for CRT implantation with EF \\\u003C 40%",[13,14],[28,33],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":10},"DIAGNOSTIC_TEST","MRI with strain measurement","CMR measurements of left and right ventricular systolic function strain and myocardial fibrosis",[20,16,9,24],{"type":29,"name":34,"description":35,"armGroupLabels":36,"otherNames":10},"Echocardiography","Doppler, PISA, VCA, volumetric method as performed during echocardiography",[20,16,9,24],[38],{"name":39,"affiliation":5,"role":40},"Deborah Kwon, M. D.","PRINCIPAL_INVESTIGATOR",[42],{"name":39,"role":43,"phone":44,"phoneExt":10,"email":45},"CONTACT","216-444-8526","kwond@ccf.org",[47],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Cleveland Clinic","RECRUITING","Cleveland","Ohio","44195","United States","US",{"type":56,"coordinates":57},"Point",[58,59],-81.69541,41.4995,{"lat":59,"lon":58},[62,63,66,68,70,72,74],{"name":39,"role":43,"phone":44,"phoneExt":10,"email":45},{"name":64,"role":65,"phone":10,"phoneExt":10,"email":10},"Richard Grimm, MD","SUB_INVESTIGATOR",{"name":67,"role":65,"phone":10,"phoneExt":10,"email":10},"Mina Chung, MD",{"name":69,"role":65,"phone":10,"phoneExt":10,"email":10},"Wlson Tang, MD",{"name":71,"role":65,"phone":10,"phoneExt":10,"email":10},"Tom Wang, MD",{"name":73,"role":65,"phone":10,"phoneExt":10,"email":10},"Christopher Nguyen, Ph.D",{"name":75,"role":65,"phone":10,"phoneExt":10,"email":10},"Tiffany Dong, MD",{"type":40,"investigatorFullName":77,"investigatorTitle":78,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Deborah Kwon, MD","Principal Investigator","100372178","comparative-imaging-assessment-of-valvular-heart-disease-100372178",false,"NCT04126018","Comparative Imaging Assessment of Valvular Heart Disease","Assessment of Left Ventricular Volumes and Strain and Assessment of Valvular Lesions Using Two- and Three-dimensional Echocardiography and Cardiac MRI, a Correlation Study","Inclusion Criteria:\n\n* Age 18-90 years of age\n* Suspected moderate or severe MR,AR or AS on the basis of prior known clinical history or clinical exam.\n* Suspected CRT \"non-responder\" with an implanted MRI compatible CRT device and reduced ejection fraction\n\nExclusion Criteria:\n\n* Acute traumatic cardiac injury\n* Aortic dissection or aortic root rupture\n* Congenital heart diseases such as patent ductus arteriosus, coarctation of aorta, ASD and VSD\n* Presence of A-V fistula or intracardiac shunts\n* Any contraindications to CMR\n* Moderate or severe dysfunction in multiple valves\n* Patients with significant claustrophobia","ALL","18 Years","90 Years",{"count":90,"type":91},200,"ESTIMATED","OBSERVATIONAL","The purpose of the study is to compare the various 2D and 3D methods of valvular heart disease quantification (Doppler, PISA, VCA, volumetric method) and strain with cardiac magnetic resonance (CMR) measurements of left and right ventricular systolic function strain and myocardial fibrosis assessment.",[95,20,96],"Valve Heart Disease","Aortic Regurgitation","2026-01-12",{"date":99,"type":100},"2026-01-13","ACTUAL",{"date":102,"type":100},"2019-08-23",{"date":104,"type":91},"2027-12-31",{"name":5,"class":6},1]