[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100594102":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":31,"centralContacts":40,"locations":46,"responsibleParty":62,"collaborators":31,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":31,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":31,"enrollmentInfo":75,"targetDuration":31,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":49,"whyStopped":31,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Pulsed Dye Laser (PDL)","ACTIVE_COMPARATOR","Participants will receive pulsed dye laser treatment (595 nm) on one defined area of their port-wine stain. The treatment will be administered using the VBeam Prima® system (Candela Medical) with standard clinical parameters: 10 mm spot size, 7-9 J\u002Fcm² fluence, and 0.5-3 ms pulse duration. Cryogen spray cooling will be used, and no anesthesia will be applied.",[13],"Device: Pulsed dye laser (PDL)",{"label":15,"type":10,"description":16,"interventionNames":17},"Potassium Titanyl Phosphate Laser (KTP)","Participants will receive potassium titanyl phosphate laser treatment (532 nm) on another defined area of the same lesion. Treatment will be performed using the DermaV® system (Lutronic Medical Systems) with standard parameters: 10 mm spot size, 8-11 J\u002Fcm² fluence, and 10 ms pulse duration. Cryogen spray cooling will be used; no anesthesia will be applied.",[18],"Device: Potassium titanyl phosphate (KTP) laser",{"label":20,"type":21,"description":22,"interventionNames":23},"Sequential KTP + PDL","EXPERIMENTAL","Participants will receive sequential treatment on a third, anatomically matched area of their port-wine stain. The area will first be treated with the KTP laser (532 nm; DermaV® system), followed immediately by pulsed dye laser (595 nm; VBeam Prima®). Parameters for each device will match those used in the monotherapy arms. Cryogen spray cooling will be applied before each pass, without anesthesia.",[24],"Device: Sequential KTP + PDL laser treatment",[26,32,36],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DEVICE","Pulsed dye laser (PDL)","Treatment with a pulsed dye laser (PDL) at 595 nm using the VBeam Prima® system (Candela Medical). Parameters: 10 mm spot size, 7-9 J\u002Fcm² fluence, 0.5-3 ms pulse duration. Cryogen spray cooling is applied. No anesthesia is used. This intervention will be applied to one of the three defined regions of each participant's port-wine stain.",[9],null,{"type":27,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"Potassium titanyl phosphate (KTP) laser","Treatment with a KTP laser at 532 nm using the DermaV® system (Lutronic Medical Systems). Parameters: 10 mm spot size, 8-11 J\u002Fcm² fluence, 10 ms pulse duration. Cryogen spray cooling is applied. No anesthesia is used. This intervention will be applied to a second anatomically comparable region of the port-wine stain.",[15],{"type":27,"name":37,"description":38,"armGroupLabels":39,"otherNames":31},"Sequential KTP + PDL laser treatment","Sequential treatment of the same region with two lasers: first with KTP (532 nm, DermaV® system), then with PDL (595 nm, VBeam Prima® system). Each laser will be applied using its standard parameters: KTP (10 mm spot, 8-11 J\u002Fcm², 10 ms), followed by PDL (10 mm spot, 7-9 J\u002Fcm², 0.5-3 ms). Cryogen spray cooling is used before each pass. No anesthesia is applied. This treatment is administered to a third region of the port-wine stain.",[20],[41],{"name":42,"role":43,"phone":44,"phoneExt":31,"email":45},"Jorge Naharro-Rodriguez, M.D.","CONTACT","+34 91 336 80 00","jorgenrmed@gmail.com",[47],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":51,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Ramon y Cajal University Hospital","RECRUITING","Madrid","Spain","28034","ES",{"type":55,"coordinates":56},"Point",[57,58],-3.70256,40.4165,{"lat":58,"lon":57},[61],{"name":42,"role":43,"phone":44,"phoneExt":31,"email":45},{"type":63,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"PRINCIPAL_INVESTIGATOR","Jorge Naharro-Rodriguez","M.D.","100594102","comparative-of-sequential-application-of-pulsed-dye-laser-and-potassium-titanyl-phosphate-laser-treatment-for-capillary-malformations-versus-single-application-100594102",false,"NCT07015073","Comparative of Sequential Application of Pulsed Dye Laser and Potassium-titanyl-phosphate Laser Treatment for Capillary Malformations Versus Single Application","Comparative Efficacy and Tolerability of Pulsed Dye Laser and Potassium-titanyl-phosphate Laser Treatment for Capillary Malformations: Sequential Versus Single Application","Inclusion Criteria:\n\n* Age ≥18\n* Fitzpatrick skin types I-IV\n* Presence of port-wine stain\n\nExclusion Criteria:\n\n* Open wounds in treatment area\n* Pregnancy\n* Nearby metal implants\n* Photodermatoses","ALL","18 Years",{"count":76,"type":77},30,"ESTIMATED","INTERVENTIONAL",[80],"NA","This prospective, non-randomized study aims to evaluate the efficacy and tolerability of treating port-wine stains (capillary malformations) using pulsed dye laser (PDL), potassium titanyl phosphate (KTP) laser, or a sequential combination of both. Each participant will receive all three treatments on different areas of the lesion. The primary outcome is improvement measured using the Investigator Global Assessment (IGA) scale. Secondary outcomes include pain (VAS), local adverse events, and patient satisfaction.",[83],"Port-Wine Stains (Capillary Malformations)",[85,86,87,88,89],"port-wine stains","capillar malformation","laser","pulsed dye laser","KTP laser","2025-06-03",{"date":92,"type":93},"2025-06-11","ACTUAL",{"date":95,"type":93},"2024-12-01",{"date":97,"type":77},"2025-08",{"name":5,"class":6},1]