[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100598185":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":35,"locations":45,"responsibleParty":78,"collaborators":82,"id":86,"slug":87,"hasResults":88,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":11,"eligibilityCriteria":92,"healthyVolunteers":93,"sex":94,"minAge":95,"maxAge":96,"enrollmentInfo":97,"targetDuration":11,"studyType":100,"phases":101,"briefSummary":103,"conditions":104,"keywords":11,"overallStatus":65,"whyStopped":11,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},{"fullName":5,"class":6},"Dr. Kurt Wolff GmbH & Co. KG","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"2% Calcium Hypophosphite Toothpaste","EXPERIMENTAL",null,[13],"Device: 2% Calcium Hypophosphite Toothpaste",{"label":15,"type":16,"description":11,"interventionNames":17},"Sodium Fluoride Toothpaste (1450 ppm F)","PLACEBO_COMPARATOR",[18],"Device: Sodium Fluoride Toothpaste (1450 ppm F)",[20,24],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":11},"DEVICE","Oral hygiene instruction and regular application of the 2% Calcium Hypophosphite Toothpaste at home (twice daily over a period of 546 days, i.e., 18 months).",[9],{"type":21,"name":15,"description":25,"armGroupLabels":26,"otherNames":11},"Oral hygiene instruction and regular application of the Sodium Fluoride Toothpaste at home (twice daily over a period of 546 days, i.e., 18 months).",[15],[28,32],{"name":29,"affiliation":30,"role":31},"Elzbieta Paszynska, Prof., DDS, Msc, PhD","Poznan University of Medical Sciences","PRINCIPAL_INVESTIGATOR",{"name":33,"affiliation":34,"role":31},"Malgorzata Pawinska, Assoc. Prof., DDS, PhD","Department of Integrated Dentistry Medical University of Białystok",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":11,"email":40},"Joachim Enax, PhD","CONTACT","+49 521 8808 6064","joachim.enax@drwolffgroup.com",{"name":42,"role":38,"phone":43,"phoneExt":11,"email":44},"Clarissa Masur, PhD","+49 521 8808 319","clarissa.masur@drwolffgroup.com",[46,63],{"facility":34,"status":47,"city":48,"state":49,"zip":50,"country":49,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"NOT_YET_RECRUITING","Bialystok","Poland","15-276","PL",{"type":53,"coordinates":54},"Point",[55,56],23.16433,53.13333,{"lat":56,"lon":55},[59],{"name":60,"role":38,"phone":61,"phoneExt":11,"email":62},"Małgorzata Pawińska, DDS, PhD","+48 693 245 095","malgosiapaw@interia.pl",{"facility":64,"status":65,"city":66,"state":49,"zip":67,"country":49,"countryCode":51,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"Poznan University of Medical Sciences, Department of Integrated Dentistry","RECRUITING","Poznan","60-812",{"type":53,"coordinates":69},[70,71],16.92993,52.40692,{"lat":71,"lon":70},[74],{"name":75,"role":38,"phone":76,"phoneExt":11,"email":77},"Elzbieta Paszynska, DDS, PhD","+48 601 55 11 89","paszynska@ump.edu.pl",{"type":79,"investigatorFullName":80,"investigatorTitle":81,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"SPONSOR_INVESTIGATOR","Dr. Joachim Enax","Senior Scientist Oral Care",[83,85],{"name":34,"class":84},"UNKNOWN",{"name":64,"class":84},"100598185","comparative-study-of-caries-preventive-effects-2-calcium-hypophosphite-toothpaste-vs-sodium-fluoride-toothpaste-1450ppm-f-100598185",false,"NCT07068204","Comparative Study of Caries-Preventive Effects: 2% Calcium Hypophosphite Toothpaste vs. Sodium Fluoride Toothpaste (1450ppm F)","Caries-preventing Effect of 2% Calcium Hypophosphite Toothpaste Compared to a Sodium Fluoride Toothpaste (1450ppm F) in Adults","Inclusion Criteria:\n\n* A minimum of 10 healthy molars and premolars (DMFS of these teeth = 0)\n* Willingness to use an electric (powered) toothbrush\n* Willingness to use interdental floss\n* Willingness to have bitewing radiographs taken\n* Willingness to undergo an oral examination by an intraoral camera (DIAGNOcam)\n\nExclusion Criteria:\n\n* Untreated caries \\[clinical investigation and analysis with an intraoral camera (DIAGNOcam)\\] (→ unsuitable subjects with one or two untreated caries in need of a restoration can become eligible after restorative therapy. If there are three or more untreated caries patients will be excluded)\n* Xerostomia (medication, radiation, disease induced)\n* Chemo\u002Fradiation therapy\n* Physical or mental disability which prevents proper oral health care\n* Orthodontic treatment\n* Severe periodontitis at the Baseline Visit (pocket depth on at least one tooth ≥ 5.5 mm)\n* Known hypersensitivity to one of the ingredients of the toothpastes to be tested\n* Regular medication intake interfering with salivary function or flow\n* Current pregnancy, the wish to become pregnant, the suspicion of being pregnant, or breastfeeding or in the course of the study\n* 3 or more carious lesions\u002Frestorations in last 36 months until Baseline Visit\n* Teeth missing due to caries in last 36 months until Baseline Visit",true,"ALL","18 Years","45 Years",{"count":98,"type":99},164,"ESTIMATED","INTERVENTIONAL",[102],"NA","The aim of the study is to compare the caries-preventive effect of the test and control toothpaste in order to proof the non-inferiority of the test toothpaste compared to the control.",[105,106,107],"Caries, Dental","Calcium Hypophosphite","Fluoridation","2026-04-10",{"date":110,"type":111},"2026-04-13","ACTUAL",{"date":113,"type":111},"2026-01-22",{"date":115,"type":99},"2028-01",{"name":80,"class":6},2]