[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100635529":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":10,"responsibleParty":24,"collaborators":10,"id":26,"slug":27,"hasResults":28,"nctId":29,"briefTitle":30,"officialTitle":30,"acronym":10,"eligibilityCriteria":31,"healthyVolunteers":28,"sex":32,"minAge":33,"maxAge":10,"enrollmentInfo":34,"targetDuration":10,"studyType":37,"phases":10,"briefSummary":38,"conditions":39,"keywords":42,"overallStatus":48,"whyStopped":10,"lastUpdateSubmitDate":49,"lastUpdatePostDateStruct":50,"startDateStruct":53,"completionDateStruct":55,"leadSponsor":57,"locationsCount":10},{"fullName":5,"class":6},"Second Affiliated Hospital of Wenzhou Medical University","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Mainstream Prosthesis Cohort",null,"Patients who underwent first-time unilateral primary total knee arthroplasty (TKA) using established mainstream prosthesis brands during the study period.",{"label":13,"type":10,"description":14,"interventionNames":10},"Emerging Prosthesis Cohort","Patients who underwent first-time unilateral primary total knee arthroplasty (TKA) using emerging prosthesis brands during the study period.",[16,21],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Ting Li, MD, PhD","CONTACT","86+13587876896","liting1021@aliyun.com",{"name":22,"role":18,"phone":10,"phoneExt":10,"email":23},"Xiaoyun Pan, MD, PhD","xiaoyunpan@wmu.edu.cn",{"type":25,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100635529","comparative-study-on-the-medium--and-long-term-benefits-of-prosthesis-selection-in-total-knee-arthroplasty-100635529",false,"NCT07553871","Comparative Study on the Medium- and Long-term Benefits of Prosthesis Selection in Total Knee Arthroplasty","Inclusion Criteria:\n\n* Age \\>= 18 years.\n* Diagnosis of end-stage knee osteoarthritis, rheumatoid arthritis, or other conditions meeting the indication for TKA.\n* First-time unilateral knee arthroplasty.\n* Complete medical records, including perioperative records, prosthesis model records, detailed cost information, and regular postoperative follow-up records.\n\nExclusion Criteria:\n\n* Revision knee arthroplasty, simultaneous bilateral arthroplasty, or concomitant arthroplasty of other joints.\n* Arthroplasty performed for non-degenerative conditions such as tumour or acute trauma.\n* Perioperative death or loss to follow-up.\n* Severely incomplete clinical data that preclude valid analysis.","ALL","18 Years",{"count":35,"type":36},3500,"ESTIMATED","OBSERVATIONAL","This retrospective real-world study aims to compare the medium- and long-term clinical outcomes, safety, and economic benefits of different knee prosthesis brands used in primary unilateral total knee arthroplasty (TKA) at our hospital. The study will include adult patients who underwent first-time unilateral TKA between January 1, 2022 and December 31, 2025. Outcomes such as postoperative knee function, complications, length of hospital stay, quality of life, and medical costs will be evaluated. The results are expected to provide evidence to support prosthesis selection and optimize healthcare resource allocation.",[40,41],"Knee Osteoarthritis","Rheumatoid Arthritis (RA)",[43,44,45,46,47],"Total Knee Arthroplasty","TKA","Cost-Effectiveness","Prosthesis Selection","Real-World Study","NOT_YET_RECRUITING","2026-04-20",{"date":51,"type":52},"2026-04-28","ACTUAL",{"date":54,"type":36},"2026-05-31",{"date":56,"type":36},"2030-12",{"name":5,"class":6}]