[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100581576":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":23,"centralContacts":28,"locations":23,"responsibleParty":34,"collaborators":23,"id":36,"slug":37,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":40,"acronym":23,"eligibilityCriteria":41,"healthyVolunteers":38,"sex":42,"minAge":43,"maxAge":44,"enrollmentInfo":45,"targetDuration":23,"studyType":48,"phases":49,"briefSummary":51,"conditions":52,"keywords":55,"overallStatus":58,"whyStopped":23,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":64,"leadSponsor":66,"locationsCount":23},{"fullName":5,"class":6},"He Eye Hospital","OTHER",[8,13],{"label":9,"type":6,"description":10,"interventionNames":11},"Study group","dry eye patients after Trans-PRK",[12],"Drug: 3% Diquafosol Sodium Eye Drops",{"label":14,"type":6,"description":10,"interventionNames":15},"Control group",[16],"Drug: 0.1% hyaluronic acid",[18,24],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"DRUG","3% Diquafosol Sodium Eye Drops","3% Diquafosol Sodium Eye Drops were instilled into the inferior conjunctival vault of both eyes",[9],null,{"type":19,"name":25,"description":26,"armGroupLabels":27,"otherNames":23},"0.1% hyaluronic acid","0.1% sodium hyaluronate eye drops were instillation into the inferior conjunctival vault of both eyes",[14],[29],{"name":30,"role":31,"phone":32,"phoneExt":23,"email":33},"Guanghao Qin Principal Investigator","CONTACT","+86-1884266442","qinguanghao2020@163.com",{"type":35,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR","100581576","compare-the-clinical-efficacy-of-3-diquafosol-and-01-hyaluronic-acid-in-patients-with-dry-eye-after-trans-prk-100581576",false,"NCT06852105","Compare the Clinical Efficacy of 3% Diquafosol and 0.1% Hyaluronic Acid in Patients with Dry Eye After Trans-PRK","Inclusion Criteria:\n\n* Age 18-40 years.\n* The refractive status should be maintained at least for more than 2 years, during which the annual increase in myopia should be controlled within 0.50 D.\n* Pherical equivalent (SE) ≤-6.00D, astigmatic power≤-2.00D.\n* Best corrected vision before surgery≥1.0.\n* Patients should stop wearing soft contact lenses for at least 2 weeks and hard contact lenses for at least 4 weeks before surgery.\n\nPostoperative corneal stromal thickness was preserved (280 μm).\n\nExclusion Criteria:\n\n* Suspected of having keratoconus, a definite diagnosis of keratoconus, or another type of corneal dilatation disease.\n* There is active inflammation or symptoms of infection in the eye.\n* The thickness of the cornea does not meet the preset cutting depth requirement: the thickness of the central cornea should be greater than 450 μm, and the thickness of the central corneal stroma remaining under the corneal flap should be maintained above 250 μm after the intended cutting (280 μm recommended).\n* Dry eye.\n* There are serious lesions in the accessory structures of the eye, such as defects or deformations of the eyelids.\n* People with uncontrolled systemic connective tissue diseases and autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis.","ALL","18 Years","40 Years",{"count":46,"type":47},76,"ESTIMATED","INTERVENTIONAL",[50],"NA","The prevalence of refractive ametropia is rising year by year. Refractive surgery has become the main approach for adults to correct refractive ametropia, and postoperative complications have aroused extensive attention from clinicians. Dry eye after refractive surgery is one of the postoperative complications, which is an important cause of affecting the postoperative visual quality and satisfaction of patients. It was reported that 3% diquafosol (DQS) and 0.1% hyaluronic acid (HA) can relieve dry eye symptoms. This study aims to compare the efficacy of 3% DQS and 0.1% HA in treating dry eye after Trans-PRK",[53,54],"Dry Eye","Tear Break-Up Time",[56,57],"dry eye","Trans-PRK","NOT_YET_RECRUITING","2025-02-21",{"date":61,"type":62},"2025-02-28","ACTUAL",{"date":61,"type":47},{"date":65,"type":47},"2026-05-31",{"name":5,"class":6}]