[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100476415":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":26,"centralContacts":30,"locations":35,"responsibleParty":52,"collaborators":10,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":10,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":10,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":10,"overallStatus":74,"whyStopped":10,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Mackay Memorial Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Genital urinary symptoms of menopause",null,"Menopause for one year, or age above 45 with symptoms of GSM",[13,14],"Drug: Vaginal estrogen supplement","Procedure: Platelet-rich plasma injection",[16,21],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":10},"DRUG","Vaginal estrogen supplement","Daily vaginal estrogen supplement, then twice per week. Continue for three months.",[9],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":10},"PROCEDURE","Platelet-rich plasma injection","Monthly platelet-rich plasma injection for three months",[9],[27],{"name":28,"affiliation":5,"role":29},"Hui-Hsuan Lau","PRINCIPAL_INVESTIGATOR",[31],{"name":28,"role":32,"phone":33,"phoneExt":10,"email":34},"CONTACT","+886-25433535","huihsuan1220@gmail.com",[36],{"facility":37,"status":10,"city":38,"state":10,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"MacKay Memorial Hospital","Taipei","104","Taiwan","TW",{"type":43,"coordinates":44},"Point",[45,46],121.52639,25.05306,{"lat":46,"lon":45},[49],{"name":50,"role":32,"phone":51,"phoneExt":10,"email":34},"Hui-Hsuan Lau, MD","+88625433535",{"type":29,"investigatorFullName":50,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Doctor","100476415","compare-vaginal-estrogen-and-platelet-rich-plasma-over-women-with-genitourinary-syndrome-of-menopause-100476415",false,"NCT05483634","Compare Vaginal Estrogen and Platelet-rich Plasma Over Women With Genitourinary Syndrome of Menopause","Compare the Effectiveness and Side Effects of Vaginal Estrogen and Platelet-rich Plasma Over Women With Genitourinary Syndrome of Menopause","Inclusion Criteria:\n\n* Women with menopause\n* Patients with symptoms of genitourinary syndrome of menopause\n\nExclusion Criteria:\n\n* Genitourinary bleeding or infection without definitive diagnosis\n* Coagulopathy\n* Allergy to medication or therapy related with the treatment\n* Chronic disease that might influence outcome\n* Using medication that might influence outcome in 30 days\n* Using hormone or steroid within 8 weeks","FEMALE","45 Years","80 Years",{"count":65,"type":66},40,"ESTIMATED","OBSERVATIONAL","The definition of Genitourinary Syndrome of Menopause (GSM) is the decline of estrogens during menopause results in symptoms and clinical signs from both systems. Estrogen and other hormones production decrease after menopause because the ovaries lose their effectiveness, leading to mucosal atrophy, reduced vaginal moisture, dysuria, urgency, recurrent infection, burning, pruritus and dyspareunia.\n\nThe treatment included vaginal estrogen supplement, vaginal hyaluronic acid supplement, vaginal laser, platelet rich plasma, etc. Observational cohort study will be used for study design, and questionnaire, pelvic examination, vaginal pap smear with maturation index (MI), vaginal pH, and other methods will be used for evaluation of the effectiveness and side effects.",[70,71,72,73],"Menopause","Platelet-rich Plasma","Estrogen Replacement Therapy","Vaginal Atrophy","NOT_YET_RECRUITING","2025-05-06",{"date":77,"type":78},"2025-05-09","ACTUAL",{"date":80,"type":66},"2025-12-01",{"date":82,"type":66},"2027-06-30",{"name":5,"class":6},1]