[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100618911":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":26,"centralContacts":32,"locations":38,"responsibleParty":55,"collaborators":26,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":26,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":26,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":26,"overallStatus":41,"whyStopped":26,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"First Affiliated Hospital of Fujian Medical University","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"High-dose group","EXPERIMENTAL","LIA with the addition of 3 vials of Diprospan (each vial contains betamethasone 5 mg + betamethasone dipropionate 2 mg)",[13],"Drug: LIA with different doses of Diprospan",{"label":15,"type":10,"description":16,"interventionNames":17},"Medium-dose group","LIA with the addition of 2 vials of Diprospan (each vial contains betamethasone 5 mg + betamethasone dipropionate 2 mg)",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Low-dose group","LIA with the addition of 1 vial of Diprospan (each vial contains betamethasone 5 mg + betamethasone dipropionate 2 mg)",[13],{"label":23,"type":24,"description":25,"interventionNames":26},"Control group","NO_INTERVENTION","LIA without the addition of Diprospan",null,[28],{"type":29,"name":30,"description":30,"armGroupLabels":31,"otherNames":26},"DRUG","LIA with different doses of Diprospan",[9,19,15],[33],{"name":34,"role":35,"phone":36,"phoneExt":26,"email":37},"Chaofan Zhang, PhD","CONTACT","+86059187982113","drcfzhang@fjmu.edu.cn",[39],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"The First Affiliated Hospital of Fujian Medical University","RECRUITING","Fuzhou","Fujian","350004","China","CN",{"type":48,"coordinates":49},"Point",[50,51],119.30611,26.06139,{"lat":51,"lon":50},[54],{"name":34,"role":35,"phone":36,"phoneExt":26,"email":37},{"type":56,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100618911","comparing-different-doses-of-corticosteroids-in-local-infiltration-analgesia-lia-for-total-knee-arthroplasty-100618911",false,"NCT07337772","Comparing Different Doses of Corticosteroids in Local Infiltration Analgesia (LIA) for Total Knee Arthroplasty","Prospective Randomized Controlled Trial Comparing Different Doses of Corticosteroids in Local Infiltration Analgesia (LIA) for Total Knee Arthroplasty","Inclusion Criteria:\n\n1. Male or female participants aged 18 years or older;\n2. Undergoing primary unilateral total knee arthroplasty (TKA)for unilateral knee osteoarthritis(OA)at ourhospital;\n3. Preoperative American Society of Anesthesiologists(ASA)physical status classification of 1-3;\n4. Ability to provide informed consent and sign a written informed consent form.\n\nExclusion Criteria:\n\n1. Previous surgery on the operative knee or a history of infection in the operative knee;\n2. Non-osteoarthritis conditions (including rheumatoid arthritis, traumatic arthritis, septic arthritis, and hemophilic arthritis);\n3. Severe osteoarthritis (including flexion contracture \\>30° or varus\u002Fvalgus deformity \\>30°);\n4. Allergy to the relevant study drugs;\n5. Presence of neuromuscular dysfunction in the ipsilateral limb;\n6. Dependence on anesthetic drugs (defined as weekly use of opioids exceeding 100 mg morphine equivalents or local anesthetics for preoperative pain control for more than 3 months);\n7. Poor systemic condition, including but not limited to: glycated hemoglobin (HbA1c) level \\>12%; blood pressure \\>170\u002F110 mmHg (1 mmHg = 0.133 kPa); history of myocardial infarction, stroke, transient ischemic attack, acute congestive heart failure, or any acute coronary event within 6 months; dialysis or renal transplantation; pregnancy or lactation.","ALL","18 Years","100 Years",{"count":68,"type":69},120,"ESTIMATED","INTERVENTIONAL",[72],"NA","This study aims to compare the efficacy of different doses of glucocorticoids in local infiltration analgesia (LIA) during total knee arthroplasty (TKA) through a prospective single-center randomized controlled trial, and to explore the safety and feasibility of high-dose glucocorticoids. Through this research, the investigators hope to provide an optimized solution for post-TKA pain management, improve patients' postoperative recovery and quality of life, and offer scientific evidence for pain management following TKA.",[75,76,77],"Adrenal Cortex Hormones","Arthroplasty, Replacement, Knee","Anesthesia, Local","2026-01-04",{"date":80,"type":81},"2026-01-13","ACTUAL",{"date":83,"type":69},"2026-02-01",{"date":85,"type":69},"2028-11-01",{"name":5,"class":6},1]