[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100614544":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":51,"collaborators":26,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":57,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":26,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":80,"overallStatus":86,"whyStopped":26,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Lady Reading Hospital, Pakistan","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Polyglactin 910 (Vicryl) Suture for Rectus Sheath Closure","EXPERIMENTAL","In this arm, participants will undergo rectus sheath closure using polyglactin 910 (Vicryl), a synthetic absorbable braided suture. This material is designed to provide temporary wound support during the healing process, with predictable hydrolytic degradation over 56-70 days. The intervention involves continuous suturing of the rectus sheath, with the suture size being 1 (USP). The primary aim is to evaluate postoperative outcomes such as incisional hernia, surgical site infections, wound dehiscence, and chronic pain, using polyglactin sutures for abdominal wall closure.Polyglactin 910 (Vicryl) Suture for Rectus Sheath Closure",[13],"Procedure: Polyglactin 910 (Vicryl) Suture",{"label":15,"type":16,"description":17,"interventionNames":18},"Polypropylene (Prolene) Suture for Rectus Sheath Closure","ACTIVE_COMPARATOR","In this arm, participants will undergo rectus sheath closure using polypropylene (Prolene), a non-absorbable monofilament suture. Polypropylene is known for its high tensile strength and biocompatibility, providing long-term mechanical support without being absorbed by the body. The intervention will involve continuous suturing of the rectus sheath, using a size 1 (USP) suture. The main focus will be to assess the incidence of complications such as incisional hernia, surgical site infection, wound dehiscence, and chronic pain following closure with polypropylene sutures.",[19],"Procedure: Polypropylene (Prolene) Suture",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Polyglactin 910 (Vicryl) Suture","Polyglactin 910 (Vicryl) is an absorbable synthetic multifilament suture material used for rectus sheath closure following laparotomy. This suture material undergoes hydrolytic degradation over a period of 56-70 days and retains approximately 75% of its tensile strength at 2 weeks and 50% at 3 weeks, which aligns with the typical biological timeline for fascial healing. It is used to approximate the anterior rectus sheath with a continuous suturing technique.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Polypropylene (Prolene) Suture","Polypropylene (Prolene) is a non-absorbable monofilament suture material used for rectus sheath closure following laparotomy. It provides long-term mechanical support for abdominal wall closure and does not degrade over time. The suture material maintains its tensile strength indefinitely and is known for its high biocompatibility, minimal tissue reaction, and resistance to infection due to its monofilament structure. It is applied using a continuous suturing technique.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Dr. Atta Ullah Arif Associate Professor, MBBS, FCPS","CONTACT","+92 333 9126978","attaullah.arif@Irh.edu.pk",[38],{"facility":39,"status":26,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":26},"Lady Reading Hospital, Department of General Surgery","Peshawar","Khyber Pakhtunkhwa","25000","Pakistan","PK",{"type":46,"coordinates":47},"Point",[48,49],71.57849,34.008,{"lat":49,"lon":48},{"type":52,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Dr. Waseem Ullah","Registrar, General Surgery","100614544","comparing-polyglactin-vs-polypropylene-sutures-for-rectus-sheath-closure-100614544",false,"NCT07280975","Comparing Polyglactin vs Polypropylene Sutures for Rectus Sheath Closure","Comparative Outcomes of Polyglactin Versus Polypropylene Sutures for Rectus Sheath Closure: A Randomized Controlled Trial","PolySuture","Inclusion Criteria:\n\n1. Age: 18-70 years.\n2. Type of Surgery: Patients undergoing elective or emergency midline laparotomy.\n3. Wound Classification: Clean or clean-contaminated wounds (CDC Class I or II).\n4. Ability to Provide Informed Consent: Participants must be able to understand and sign the informed consent form.\n5. Availability for Follow-Up: Participants must be available for 6 months follow-up.\n\nExclusion Criteria:\n\n1. Contaminated or Dirty Wounds: Patients with CDC Class III or IV wounds.\n2. Immunocompromised Conditions: Patients on steroids, chemotherapy, or those with HIV.\n3. Previous Midline Laparotomy with Incisional Hernia: Patients who have a history of incisional hernia after midline laparotomy.\n4. Severe Malnutrition: Patients with BMI \\\u003C 16 kg\u002Fm² or albumin \\\u003C 2.5 g\u002FdL.\n5. Emergency Laparotomy with Hemodynamic Instability: Patients who are unstable or in a critical condition.\n6. Pregnancy: Pregnant women.\n7. Need for Temporary Abdominal Closure or Planned Reoperation: Patients requiring staged reoperation or temporary closure.","ALL","18 Years","70 Years",{"count":67,"type":68},156,"ESTIMATED","INTERVENTIONAL",[71],"NA","This randomized controlled trial aims to compare the outcomes of Polyglactin (Vicryl) versus Polypropylene (Prolene) sutures for rectus sheath closure in patients undergoing midline laparotomy. The study will evaluate the rates of incisional hernia, surgical site infection (SSI), wound dehiscence, chronic pain, and suture sinus formation. Participants aged 18-70 years, undergoing either elective or emergency laparotomy, will be randomly assigned to receive either Polyglactin or Polypropylene sutures. The primary outcome measure is the incidence of incisional hernia at 6 months, with secondary outcomes including SSI, wound complications, and chronic pain. The study is particularly important in the context of Pakistan, where such comparative data is limited, and aims to provide evidence-based recommendations for optimal suture material selection in general surgery.",[74,75,76,77,78,79],"Chronic Pain","Wound Dehiscence","Surgical Site Infection (SSI)","Incisional Hernia","Rectus Sheath Closure","Abdominal Surgery",[81,82,83,84,85],"Polyglactin Sutures","Polypropylene Sutures","Non-Absorbable Sutures","Postoperative Complications","Midline Laparotomy","NOT_YET_RECRUITING","2025-12-09",{"date":89,"type":90},"2025-12-15","ACTUAL",{"date":92,"type":68},"2026-04-01",{"date":94,"type":68},"2027-07-30",{"name":5,"class":6},1]