[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100587763":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":30,"centralContacts":37,"locations":43,"responsibleParty":61,"collaborators":30,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":30,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":30,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":85,"overallStatus":46,"whyStopped":30,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Tri-Service General Hospital","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Lyophilized self growth factor","EXPERIMENTAL","Knee Intraarticular injection with Lyophilized self growth factor",[13],"Procedure: Lyophilized self growth factor",{"label":15,"type":16,"description":17,"interventionNames":18},"Platelet-Rich Plasma(PRP)","ACTIVE_COMPARATOR","Knee intraarticular injection with Platelet-Rich Plasma(PRP)",[19],"Procedure: Platelet-Rich Plasma(PRP)",{"label":21,"type":22,"description":23,"interventionNames":24},"normal saline","PLACEBO_COMPARATOR","Knee intraarticular injection with normal saline",[25],"Procedure: Placebo",[27,31,33],{"type":28,"name":9,"description":11,"armGroupLabels":29,"otherNames":30},"PROCEDURE",[9],null,{"type":28,"name":15,"description":11,"armGroupLabels":32,"otherNames":30},[15],{"type":28,"name":34,"description":35,"armGroupLabels":36,"otherNames":30},"Placebo","Knee Intraarticular injection with normal saline",[21],[38],{"name":39,"role":40,"phone":41,"phoneExt":30,"email":42},"Yu Chi Su,, MD","CONTACT","+886287923311","vickysu0110@gmail.com",[44],{"facility":45,"status":46,"city":47,"state":30,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"No. 325, Sec. 2, Chenggong Rd., Neihu Dist.","RECRUITING","Taipei","114","Taiwan","TW",{"type":52,"coordinates":53},"Point",[54,55],121.52639,25.05306,{"lat":55,"lon":54},[58],{"name":59,"role":40,"phone":60,"phoneExt":30,"email":42},"Yu Chi Su, MD","+886-2-8792-3311",{"type":62,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Yu-CHI Su","Attending Physician and lecturer of Department of Physical Medicine and Rehabilitation","100587763","comparing-the-efficacy-of-lyophilized-self-growth-factor-versus-prp-injection-for-knee-oa-100587763",false,"NCT06932614","Comparing the Efficacy of Lyophilized Self Growth Factor Versus PRP Injection for Knee OA","Comparing the Efficacy of Lyophilized Self Growth Factor Versus Platelet-Rich Plasma(PRP) Injection for Knee Osteoarthritis: A Prospective, Double-Blind, Randomized Controlled Trial","Inclusion Criteria:\n\n* Male or female, aged over 20 and under 80.\n* Consciousness clear and able to communicate.\n* Unilateral or bilateral osteoarthritis of the knee with symptoms lasting more than 3 months.\n* X-ray imaging shows mild to moderate knee osteoarthritis (Kellgren-Lawrence grades 1-3).\n* Knee joint pain with a Visual Analogue Scale (VAS) score greater than 4.\n\nExclusion Criteria:\n\n* Severe knee osteoarthritis (Kellgren-Lawrence grade 4).\n* Currently systemic infection.\n* Received hyaluronic acid or corticosteroid intraarticular injections within the past six months, or received NSAIDs or oral corticosteroid treatment within 7 days prior to treatment.\n* The treated joint has undergone joint replacement surgery or major surgery.\n* Severe knee deformity or instability.\n* Known history of cancers, rheumatoid arthritis, platelet dysfunction, thrombocytopenia, hypofibrinogenemia, acute or chronic infectious diseases, chronic liver disease, or poorly controlled cardiovascular disease or diabetes.\n* Currently receiving anticoagulant therapy.\n* Long-term or excessive use of aspirin or vitamin E.\n* History of HIV\u002FAIDS, syphilis, or other legally notifiable infectious diseases.\n* Pregnant or breastfeeding women, or women and men of childbearing potential who are unable to use effective contraception during the treatment period.\n* Deemed unsuitable for participation in the trial by the principal investigator.\n* Unable to sign the informed consent form.","ALL","20 Years","80 Years",{"count":76,"type":77},90,"ESTIMATED","INTERVENTIONAL",[80],"NA","Knee osteoarthritis(OA) is a common degenerative joint disease that often leads to knee pain, stiffness, and a decline in quality of life among middle-aged and elderly individuals. Platelet-rich plasma (PRP) is a regenerative treatment method that involves drawing a small amount of the patient's own blood and using centrifugation process to produce PRP. PRP, which is rich in growth factors and anti-inflammatory cytokines, facilitate the repair of damaged tissues and has been used in treating knee OA. Self-repair factor (SRF), an advanced form of PRP, is created using multi-step centrifugation and proprietary processes to increase platelet concentration. This enhancement may offer superior repair efficacy and faster recovery compared to traditional PRP. To explore this potential, we designed a randomized, double-blind, clinical trial to compare the effectiveness of SRF and PRP in treating degenerative knee osteoarthritis.",[83,84],"Knee Osteoarthritis","PRP Injection",[83,86],"PRP injection","2025-09-03",{"date":89,"type":90},"2025-09-10","ACTUAL",{"date":92,"type":90},"2025-08-01",{"date":94,"type":77},"2026-07-31",{"name":5,"class":6},1]