[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100614054":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":35,"locations":41,"responsibleParty":55,"collaborators":25,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":25,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":25,"enrollmentInfo":66,"targetDuration":25,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":76,"overallStatus":80,"whyStopped":25,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Total thyroidectomy","ACTIVE_COMPARATOR","Patients randomised to this arm will undergo total thyroidectomy with bilateral central compartment (level VI) neck dissection",[13],"Procedure: Total thyroidectomy",{"label":15,"type":16,"description":17,"interventionNames":18},"extended isthmusectomy","EXPERIMENTAL","Patients randomised to this arm will undergo extended isthmusectomy (ensure R0 resection) with bilateral central compartment (level VI) neck dissection",[19],"Procedure: Extended isthmusectomy",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Total Thyroidectomy with bilateral central compartment (level VI) neck dissection - surgical removal of entire thyroid gland and perform bilateral Level VI neck dissection. This is the standard treatment recommended by the Chinese Guidelines for the Diagnosis and Management of Thyroid Nodules and Differentiated Thyroid Cancer (2nd Edition).\n\nThe participating surgeons all routinely perform complete central neck dissections. They were selected for this study due to their standardized technique, which ensures a consistent surgical approach.",[9],null,{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Extended isthmusectomy","Extended isthmusectomy with bilateral central compartment (level VI) neck dissection : Completely resect the isthmus and portions of the bilateral thyroid gland adjacent to the isthmus, ensuring an R0 resection margin for the tumor, while preserving at least more than half of the bilateral thyroid lobes.",[15],[31],{"name":32,"affiliation":33,"role":34},"Zhiyu Li, MD","Thyroid surgery Department, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, China","PRINCIPAL_INVESTIGATOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},"Jingying Zhang, MD","CONTACT","+86 15024439310","jyzhang_hz@126.com",[42],{"facility":43,"status":25,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":25},"2nd Affiliated Hospital, School of Medicine, Zhejiang University, China","Hangzhou","Zhejiang","310000","China","CN",{"type":50,"coordinates":51},"Point",[52,53],120.16142,30.29365,{"lat":53,"lon":52},{"type":56,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100614054","comparing-the-therapeutic-efficacy-of-extended-isthmusectomy-versus-total-thyroidectomy-for-isthmus-tumors-of-the-thyroid-100614054",false,"NCT07274605","Comparing the Therapeutic Efficacy of Extended Isthmusectomy Versus Total Thyroidectomy for Isthmus Tumors of the Thyroid","Comparing the Therapeutic Efficacy of Extended Isthmusectomy Versus Total Thyroidectomy for Isthmus Tumors of the Thyroid: A Prospective, Multicenter, Open-Label, Randomized Controlled Trial.","Inclusion Criteria:\n\n\\- Age 18 years or older.\n\nDiagnosis of low-risk differentiated thyroid cancer (papillary, follicular, or Hürthle cell carcinoma).\n\nUnifocal tumor located in the thyroid isthmus, cT1b\n\nNo evidence of extrathyroidal extension, assessed by preoperative ultrasound.\n\nExclusion Criteria:\n\n\\- Aggressive pathological subtypes (e.g., tall cell, clear cell, columnar cell, or diffuse sclerosing variants of papillary thyroid carcinoma, as well as poorly differentiated types).\n\ncN1b.\n\nM1\n\nCombined with other suspicious thyroid nodules within the lobes.","ALL","18 Years",{"count":67,"type":68},520,"ESTIMATED","INTERVENTIONAL",[71],"NA","Prospective randomized open phase III non-inferiority trial in cT1bN0N1aM0 isthmus tumors of the thyroid comparing: extended Isthmusectomy (Isthmusectomy + Central Neck Dissection)(experimental group) versus total thyroidectomy + Central Neck Dissection (reference group).",[74,75],"Thymectomy","Thyroid Cancer",[77,78,79],"thyroid cancer","isthmus","surgery","NOT_YET_RECRUITING","2025-12-09",{"date":83,"type":84},"2025-12-10","ACTUAL",{"date":86,"type":68},"2025-12-19",{"date":88,"type":68},"2032-12-01",{"name":5,"class":6},1]