[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626047":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":53,"centralContacts":59,"locations":66,"responsibleParty":92,"collaborators":94,"id":97,"slug":98,"hasResults":99,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":99,"sex":105,"minAge":106,"maxAge":64,"enrollmentInfo":107,"targetDuration":64,"studyType":110,"phases":111,"briefSummary":113,"conditions":114,"keywords":117,"overallStatus":69,"whyStopped":64,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":132},{"fullName":5,"class":6},"Imperial College London","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Biventricular pacing","ACTIVE_COMPARATOR","Current standard of care cardiac resynchronisation therapy with biventricular pacing (one lead to right ventricular endocardium and one lead to left ventricular epicardium, accessed via the coronary sinus).",[13],"Device: Biventricular pacing",{"label":15,"type":16,"description":17,"interventionNames":18},"Conduction system pacing","EXPERIMENTAL","Cardiac resynchronisation therapy with single lead targeting direct capture of the conduction system. Primary target should be left bundle area, with backup target of His bundle.",[19],"Device: Conduction system pacing",{"label":21,"type":16,"description":22,"interventionNames":23},"Left bundle optimised cardiac resynchronisation therapy (LOT-CRT)","Cardiac resynchronisation therapy delivered by conduction system optimised hybrid configurations. Primary configuration should be conduction system pacing lead targeted at the left bundle area combined with left ventricular epicardial lead accessed via the coronary sinus (LOT-CRT). Backup configuration of conduction system pacing lead targeted at the His bundle combined with left ventricular epicardial lead accessed via the coronary sinus (HOT-CRT).",[24],"Device: Left bundle optimised cardiac resynchronisation therapy",[26,32,46],{"type":27,"name":9,"description":28,"armGroupLabels":29,"otherNames":30},"DEVICE","Cardiac resynchronisation therapy with one lead to right ventricular endocardium and one lead to left ventricular epicardium, accessed via the coronary sinus.",[9],[31],"BVP",{"type":27,"name":15,"description":33,"armGroupLabels":34,"otherNames":35},"Cardiac resynchronisation therapy with single lead targeting direct capture of the conduction system. Primary target should be left bundle area, with backup target of His bundle. If direct capture of the conduction system cannot be achieved by conventional clinical criteria, left septal pacing targeted at the left bundle branch area will be accepted.",[15],[36,37,38,39,40,41,42,43,44,45],"Physiological pacing","CSP","Left bundle branch pacing","Left bundle branch area pacing","Left septal pacing","His bundle pacing","LBBP","LBBAP","LSP","HBP",{"type":27,"name":47,"description":22,"armGroupLabels":48,"otherNames":49},"Left bundle optimised cardiac resynchronisation therapy",[21],[50,51,52],"LOT-CRT","His bundle optimised cardiac resynchronisation therapy","HOT-CRT",[54,57],{"name":55,"affiliation":5,"role":56},"Zachary I Whinnett, MBBS, BMedSci, MRCP, PhD","PRINCIPAL_INVESTIGATOR",{"name":58,"affiliation":5,"role":56},"Ahran D Arnold, MBBS, BSc, MSc, MRCP, PhD",[60],{"name":61,"role":62,"phone":63,"phoneExt":64,"email":65},"Jack W Samways, MBChB, MRes, MRCP","CONTACT","+4420 331 33000",null,"jsamways@ic.ac.uk",[67],{"facility":68,"status":69,"city":70,"state":71,"zip":72,"country":73,"countryCode":74,"cosmosGeoPoint":75,"geoPoint":80,"contacts":81},"Hammersmith Hospital, Imperial College Healthcare NHS Trust","RECRUITING","London","Greater London","W12 0HS","United Kingdom","UK",{"type":76,"coordinates":77},"Point",[78,79],-0.12574,51.50853,{"lat":79,"lon":78},[82,86,90],{"name":83,"role":62,"phone":84,"phoneExt":85,"email":65},"Jack W Samways, MBChB MRes (Merit) MRCP(UK)","+44 (0) 20 3311 3311","Ask for JWS",{"name":87,"role":62,"phone":84,"phoneExt":88,"email":89},"Ahran D Arnold, MBBS BSc MSc MRCP PhD","Ask for ADA","ada104@ic.ac.uk",{"name":91,"role":56,"phone":64,"phoneExt":64,"email":64},"Zachary I Whinnett, BMBS BMEDSCI MRCP PhD",{"type":93,"investigatorFullName":64,"investigatorTitle":64,"investigatorAffiliation":64,"oldNameTitle":64,"oldOrganization":64},"SPONSOR",[95],{"name":96,"class":6},"Imperial College Healthcare NHS Trust","100626047","comparing-three-types-of-specialist-pacemakers-to-improve-heart-function-and-reduce-rhythm-problems-in-heart-failure-100626047",false,"NCT07430553","Comparing Three Types of Specialist Pacemakers to Improve Heart Function and Reduce Rhythm Problems in Heart Failure","Randomised Investigation of Physiological, Conventional and Optimised Resynchronisation Therapy in Heart Failure With Prolonged QRS Duration (RIPCORD-CRT)","RIPCORD-CRT","Inclusion Criteria:\n\nPatients referred\u002Fscheduled for a CRT procedure (new implant or upgrade) who have:\n\n* Symptomatic heart failure (NYHA II-IV)\n* Reduced ejection fraction (LVEF≤40%)\n* Prolonged QRS duration (≥130ms) and left bundle branch block ECG morphology or very prolonged QRS duration (\\>150ms) and non-left bundle branch block ECG\n* Optimal medical therapy for HF\n\nExclusion Criteria:\n\n* Unable to provide informed consent\n* \\\u003C18 years old\n* Pregnant patients (with female patients of childbearing age requiring a negative urine BHCG)","ALL","18 Years",{"count":108,"type":109},60,"ESTIMATED","INTERVENTIONAL",[112],"NA","The goal of this clinical trial is to find out which type of specialist pacemaker-known as cardiac resynchronisation therapy (CRT)-works best for people with heart failure and a delay in how the lower chambers of the heart beat together (called electrical dyssynchrony).\n\nThe main aims of the study are:\n\nTo compare the effects of conventional biventricular pacing (BVP), conduction system pacing (CSP) and left-bundle optimised CRT (LOT-CRT) on heart failure symptoms and heart rhythm problems over six months.\n\nTo explore how these pacing methods affect heart muscle strength, electrical activity, and overall heart function.\n\nParticipants will:\n\nAttend four hospital visits over a six-month period.\n\nAt Visit 1, meet a member of the research team to discuss the study and have screening tests to check eligibility. Participants will also have a smartphone app installed and receive training on how to record their daily heart failure symptoms.\n\nAt Visit 2, have a CRT pacemaker implanted. The type of pacemaker will be chosen at random, with a 1 in 3 chance of receiving:\n\n* Biventricular pacing (BVP); the current standard treatment\n* Conduction system pacing (CSP)\n* LOT-CRT (Left-bundle optimised CRT); a combination of both\n\nAt Visit 3 (around 12 weeks after implantation) and Visit 4 (6 months after implantation), take part in routine follow-up assessments to check the pacemaker and heart function.\n\nAt Visits 2 and 4, also undergo non-invasive electrical mapping tests, including wearing a specialised vest and having a low-dose CT scan of the chest. These tests help researchers understand how the heart's electrical system responds to different pacing methods.",[115,116],"Heart Failure and Reduced Ejection Fraction","Dyssynchrony",[118,15,119,50,120,121,122],"Cardiac resynchronisation therapy","optimised CRT","heart failure","dyssynchrony","left bundle branch pacing","2026-02-17",{"date":125,"type":126},"2026-02-24","ACTUAL",{"date":128,"type":126},"2025-11-12",{"date":130,"type":109},"2028-10-24",{"name":5,"class":6},1]