[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611373":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":26,"responsibleParty":37,"collaborators":26,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":26,"eligibilityCriteria":47,"healthyVolunteers":43,"sex":48,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":26,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":66,"whyStopped":26,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":26},{"fullName":5,"class":6},"College of Physicians and Surgeons Pakistan","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Triple Antibiotic Paste (TAP)","EXPERIMENTAL","TAP placed as intracanal medicament following chemo-mechanical preparation; temporary restoration maintained for several weeks",[13,14],"Drug: Triple Antibiotic Paste","Drug: Calcium Hydroxide (Ca(OH)2)",{"label":16,"type":17,"description":18,"interventionNames":19},"Calcium Hydroxide Group","ACTIVE_COMPARATOR","Calcium Hydroxide intracanal dressing placed following chemo-mechanical preparation; sealed temporarily",[13,14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Triple Antibiotic Paste","Intracanal medicament paste composed of Ciprofloxacin, Metronidazole, and Minocycline. Placed in the root canal for several weeks.",[16,9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Calcium Hydroxide (Ca(OH)2)","Standard intracanal medicament with high pH, used for its antibacterial and tissue-stimulating properties. Placed in the root canal for several weeks",[16,9],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Faiz Rahman","CONTACT","+923451505838","faizr3702@gmail.com",{"type":38,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Faiz ur rahman","Postgraduate Resident, Department of Operative Dentistry","100611373","comparing-two-medicines-for-healing-jaw-bone-infections-after-root-canal-treatment-100611373",false,"NCT07239739","Comparing Two Medicines for Healing Jaw Bone Infections After Root Canal Treatment","Effect of Triple Antibiotic Paste and Calcium Hydroxide on the Rate of Healing of Periapical Lesions in Single-Rooted Teeth: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Systemically healthy adult patients between 18 and 65 years of age.\n\nPresence of a single-rooted tooth diagnosed with pulpal necrosis and asymptomatic apical periodontitis or chronic apical abscess.\n\nRadiographic evidence of a distinct periapical radiolucency with a minimum diameter of 2mm.\n\nThe involved tooth must be deemed restorable after endodontic treatment.\n\nPatient willingness and ability to provide informed consent and comply with the follow-up schedule\n\nExclusion Criteria:\n\nPatients under 18 or over 65 years of age.\n\nPresence of systemic diseases known to affect bone metabolism or immune response (e.g., uncontrolled diabetes).\n\nPregnancy or lactation.\n\nKnown allergies to any components of Triple Antibiotic Paste or calcium hydroxide.\n\nTeeth with previous root canal treatment, internal\u002Fexternal root resorption, root fractures, or non-endodontic periapical pathology.Exclusion Criteria:\n\n\\-","ALL","18 Years","65 Years",{"count":52,"type":53},62,"ESTIMATED","INTERVENTIONAL",[56],"NA","This study compares two commonly used intracanal medicaments-Triple Antibiotic Paste and Calcium Hydroxide-in patients with infected single-rooted teeth. The purpose is to determine which medicament promotes faster healing of periapical lesions after root canal treatment by measuring reduction in lesion size and improvement in bone density over 3, 6, and 12 months.",[59,60],"Periapical Lesion","Periapical Periodontitis",[62,63,64,65],"Triple Antibiotic Paste,","Calcium Hydroxide,","Periapical Healing","Intracanal Medicament","NOT_YET_RECRUITING","2026-03-16",{"date":69,"type":70},"2026-03-18","ACTUAL",{"date":72,"type":53},"2026-06-15",{"date":74,"type":53},"2026-12-15",{"name":39,"class":6}]