[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100599037":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":11,"centralContacts":31,"locations":37,"responsibleParty":53,"collaborators":11,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":11,"enrollmentInfo":66,"targetDuration":11,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":76,"overallStatus":85,"whyStopped":11,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Egas Moniz - Cooperativa de Ensino Superior, CRL","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Aerobic Exercise with Blood Flow Restriction","EXPERIMENTAL",null,[13],"Other: Low Intensity Aerobic Exercise with Blood Flow Restriction (LIAE+BFR)",{"label":15,"type":16,"description":11,"interventionNames":17},"Aerobic Exercise Without Blood Flow Restriction","ACTIVE_COMPARATOR",[18],"Other: High Intensity Interval Exercise (HIIE)",{"label":20,"type":21,"description":11,"interventionNames":11},"No Exercise or Blood Flow Restriction","NO_INTERVENTION",[23,27],{"type":6,"name":24,"description":25,"armGroupLabels":26,"otherNames":11},"Low Intensity Aerobic Exercise with Blood Flow Restriction (LIAE+BFR)","In the LIAE+BFR condition, participants will walk on a treadmill for 20 minutes at 30-40% of heart rate reserve (HRR), with a pneumatic cuff inflated to 1.3 times the individual's ankle systolic blood pressure, using a 5cm wide x 75cm long commercial cuff around each upper thigh.\n\nTreadmill speed will be adjusted dynamically to maintain target intensities, while the incline remains at 1%. Heart Rate, the Modified Borg Rate of Perceived Exertion scale, and the Rating of perceived discomfort will be continuously monitored throughout both exercise sessions to ensure adherence to the prescribed intensity levels.",[9],{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":11},"High Intensity Interval Exercise (HIIE)","In the HIIE condition, participants will perform a 20 minutes treadmill-based HIAE, alternating between 60-seconds high-intensity intervals at 60-89% HRR and 60-second active recovery intervals at 40-50% HRR.\n\nTreadmill speed will be adjusted dynamically to maintain target intensities, while the incline remains at 1%. Heart Rate, the Modified Borg Rate of Perceived Exertion scale, and the Rating of perceived discomfort will be continuously monitored throughout both exercise sessions to ensure adherence to the prescribed intensity levels.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":11,"email":36},"Xavier Melo, PhD","CONTACT","+351 212946700","xmelo@egasmoniz.edu.pt",[38],{"facility":39,"status":11,"city":40,"state":11,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Egas Moniz School of Health and Science","Almada","2829-511","Portugal","PT",{"type":45,"coordinates":46},"Point",[47,48],-9.1569,38.67902,{"lat":48,"lon":47},[51],{"name":33,"role":34,"phone":52,"phoneExt":11,"email":36},"+351212946700",{"type":54,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100599037","comparing-vascular-responses-to-aerobic-exercise-with-and-without-blood-flow-restriction-in-young-and-older-adults-100599037",false,"NCT07079280","Comparing Vascular Responses to Aerobic Exercise With and Without Blood Flow Restriction in Young and Older Adults","Comparison of Acute Micro- and Macrovascular Responses to Aerobic Exercise With and Without Blood Flow Restriction in Young and Older Adults: A Randomized Crossover Trial.","UNDER PRESSURE","Inclusion Criteria:\n\n* Aged between 18-30 years and those over 60 years.\n\nExclusion Criteria:\n\n* Past or current history of coronary heart disease, stroke, oncological disease, or major cardiovascular events.\n* Individuals who had undergone surgery within the last two months\n* Body mass index (BMI) greater than 30 kg\u002Fm²\n* Declared sleep apnea\n* Active kidney or liver disease\n* Active tobacco smokers\n* Sensory impairments\n* Neurological or orthopedic functional impairments, musculoskeletal pathologies affecting exercise capacity\n* Physically active for more than six months with a weekly activity level of 1,000 MET\u002Fmin.",true,"ALL","18 Years",{"count":67,"type":68},52,"ESTIMATED","INTERVENTIONAL",[71],"NA","Aging is a major risk factor for cardiovascular disease (CVD), contributing to progressive macrovascular and microvascular dysfunction. Macrovascular impairments, such as arterial stiffening and endothelial dysfunction, reduce nitric oxide (NO) bioavailability, leading to hypertension and impaired blood flow regulation. Microvascular dysfunction exacerbates cardiovascular decline by compromising capillary perfusion and tissue oxygenation, increasing susceptibility to ischemic events. Preserving vascular function is essential for maintaining cardiovascular health in aging populations.\n\nLow-intensity aerobic exercise (LIAE) improves cardiovascular health and mobility, particularly in populations unable to perform high-intensity exercise. However, LIAE alone often fails to induce significant vascular adaptations, such as improved arterial compliance or endothelial function, highlighting the need for optimized interventions.\n\nBlood Flow Restriction (BFR) enhances vascular adaptations during low-intensity exercise by inducing localized hypoxia, stimulating endothelial function and arterial remodeling. While BFR may transiently increase blood pressure and arterial stiffness, its vascular benefits resemble those of high-intensity exercise at lower workloads. However, research on BFR's acute vascular effects during aerobic exercise in older adults remains limited.\n\nCurrent studies have focused on perceptual and hemodynamic responses to LIAE+BFR but lack direct assessments of macrovascular (e.g., flow-mediated slowing) and microvascular function. Older adults may exhibit distinct vascular responses, yet data are scarce. This study examines acute vascular responses to LIAE+BFR and high-intensity interval exercise (HIIE) in young and older adults.\n\nHypothesis:\n\n1. BFR combined with LIAE will elicit greater acute microvascular and macrovascular responses in older adults than in younger adults.\n2. These responses will be comparable to HIIE without BFR, suggesting BFR enhances LIAE's efficacy to high-intensity levels.\n3. Any transient vascular dysfunction (e.g., increased arterial stiffness) will normalize within 30 minutes post-exercise, supporting safety in aging populations.",[74,75],"Ageing","Blood Flow Restriction (BFR) Training Effects",[77,78,79,80,81,82,83,84],"Aerobic Exercise","Blood Flow Restriction","Microvascular Function","Flow mediated Slowing","Arterial Stiffness","Central Blood Pressure","Young Adults","Older Adults","NOT_YET_RECRUITING","2025-07-13",{"date":88,"type":89},"2025-07-23","ACTUAL",{"date":91,"type":68},"2025-10-06",{"date":93,"type":68},"2026-07-31",{"name":5,"class":6},1]