[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100580414":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":41,"responsibleParty":60,"collaborators":26,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":26,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":26,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Dow University of Health Sciences","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group P","ACTIVE_COMPARATOR","Prophylactic bolus of phenylephrine will be administered right after spinal anesthesia induction",[13],"Drug: Phenylephrine bolus",{"label":15,"type":16,"description":17,"interventionNames":18},"Group N","EXPERIMENTAL","Prophylactic bolus of norepinephrine will be administered right after spinal anesthesia.",[19],"Drug: Norepinephrine Bolus",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Norepinephrine Bolus","Prophylactic norepinephrine bolus of 8 micrograms will be administered right after spinal anesthesia induction.\n\nRescue bolus of norepinephrine 4 micrograms will be administered in case of hypotension.",[15],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Phenylephrine bolus","Prophylactic phenylephrine bolus of 100 micrograms will be administered right after spinal anesthesia induction.\n\nRescue bolus of phenylephrine 50 micrograms will be administered in case of hypotension.",[9],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Rabia Kamal, MBBS","CONTACT","923342239607","rabiakamal.ae@gmail.com",{"name":38,"role":34,"phone":39,"phoneExt":26,"email":40},"Arsalan Jamil, FCPS","923341226693","22arsalan@gmail.com",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Dr Ruth km pfau civil hospital karachi Dow University of health sciences, department of anesthesiology","RECRUITING","Karachi","Sindh","74200","Pakistan","PK",{"type":51,"coordinates":52},"Point",[53,54],67.0104,24.8608,{"lat":54,"lon":53},[57],{"name":58,"role":59,"phone":26,"phoneExt":26,"email":26},"Rabia Kamal, FCPS Tainee","PRINCIPAL_INVESTIGATOR",{"type":59,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Rabia Kamal","FCPS Anesthesiology resident","100580414","comparison-between-efficacy-of-norepinephrine-and-phenylephrine-boluses-for-prevention-of-spinal-anaesthesia-induced-hypotension-in-obstetrical-patients-undergoing-emergency-cesarean-section-a-double-blind-randomized-controlled-trial-100580414",false,"NCT06836986","COMPARISON BETWEEN EFFICACY OF NOREPINEPHRINE AND PHENYLEPHRINE BOLUSES for PREVENTION OF SPINAL ANAESTHESIA INDUCED HYPOTENSION IN OBSTETRICAL PATIENTS UNDERGOING EMERGENCY CESAREAN SECTION-A Double Blind Randomized Controlled Trial","COMPARISON BETWEEN EFFICACY OF NOREPINEPHRINE AND PHENYLEPHRINE BOLUSES FOR PREVENTION OF SPINAL ANAESTHESIA INDUCED HYPOTENSION IN OBSTETRICAL PATIENTS UNDERGOING EMERGENCY CESAREAN SECTION- A Double Blind Randomized Controlled Trial","Inclusion Criteria:\n\n1. American society of anesthesiologists II and III patients\n2. Age 18-40years\n3. Gestational age 32 weeks and above\n\nExclusion Criteria:\n\n1. Patients with hypertensive disorders of pregnancy having baseline systolic blood pressure greater than 160 mmHg and diastolic blood pressure greater than 99 mmHg.\n2. Baseline mean arterial pressure less than 70 mmHg.\n3. Antepartum hemorrhage\u002Fintraoperative blood loss greater than 1000ml\n4. history indicative of cardiovascular or neurological disease.\n5. known fetal abnormality.\n6. Patients taking serotonin reuptake inhibitor, Tricyclic antidepressants,monoamine oxidase inhibitors.\n7. Maternal situations requiring immediate administration of general anesthesia","FEMALE","18 Years","40 Years",{"count":74,"type":75},124,"ESTIMATED","INTERVENTIONAL",[78],"NA","The goal of this clinical trial is to learn if norepinephrine is more effective than phenylephrine for prevention of spinal anesthesia induced hypotension. The main questions it aims to answer are:\n\nDoes norepinephrine lower the incidence of spinal anesthesia induced hypotension in emergency obstetrical patients? We will compare effectiveness of norepinephrine and phenylephrine for the prevention of spinal anesthesia induced hypotension.\n\nParticipants will:\n\nBe administered prophylactic boluses of both drugs right after spinal anesthesia induction and maternal hemodynamic parameters and neonatal APGAR scores will be recorded",[81],"Spinal Anesthesia Induced Hypotension",[83,84,85,86,87],"Spinal anesthesia induced hypotension","Emergency lower segment cesarean section","Norepinephrine bolus","Prophylactic","Phenylephrine","2025-02-16",{"date":90,"type":91},"2025-02-20","ACTUAL",{"date":93,"type":91},"2024-12-31",{"date":95,"type":75},"2025-03-31",{"name":5,"class":6},1]