[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100574425":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":29,"centralContacts":36,"locations":47,"responsibleParty":61,"collaborators":29,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":29,"eligibilityCriteria":71,"healthyVolunteers":72,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":29,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":50,"whyStopped":29,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Zagazig University","OTHER_GOV",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Control group (group C)","ACTIVE_COMPARATOR","The patient receive unilateral ultrasound guided combined IPACK and ACB with bupivacaine only. two syringes , one for each block , each one contains (20 mL of 0.25% bupivacaine and 1 ml saline)",[13],"Procedure: Control group",{"label":15,"type":10,"description":16,"interventionNames":17},"Fentanyl group (group F)","The patient receive unilateral ultrasound guided combined IPACK and ACB with bupivacaine only. two syringes , one for each block , each one contains (20 mL of 0.25% bupivacaine and 50 mcg fentanyl)",[18],"Procedure: Fentanyl group",{"label":20,"type":10,"description":21,"interventionNames":22},"Dexmedetomidine group (group D)","The patient receive unilateral ultrasound guided combined IPACK and ACB with bupivacaine only. two syringes , one for each block , each one contains (20 mL of 0.25% bupivacaine and 1 ug\u002Fkg dexmedetomidine not exceeding 100 ug (to be completed to 1mL with normal saline if needed). )",[23],"Procedure: Dexmedetomidine group",[25,30,33],{"type":26,"name":27,"description":11,"armGroupLabels":28,"otherNames":29},"PROCEDURE","Control group",[9],null,{"type":26,"name":31,"description":16,"armGroupLabels":32,"otherNames":29},"Fentanyl group",[15],{"type":26,"name":34,"description":21,"armGroupLabels":35,"otherNames":29},"Dexmedetomidine group",[20],[37,43],{"name":38,"role":39,"phone":40,"phoneExt":41,"email":42},"Dina Sadek Salem, MD","CONTACT","01099333513","002","sherifelagamy@yahoo.com",{"name":44,"role":39,"phone":45,"phoneExt":41,"email":46},"Sherif Mowafy, MD","01003523374","sherifmowafy2012@gmail.com",[48],{"facility":49,"status":50,"city":51,"state":29,"zip":29,"country":52,"countryCode":53,"cosmosGeoPoint":29,"geoPoint":29,"contacts":54},"faculty of human medicine, Zagazig university hospitals","RECRUITING","El Sharkia","Egypt","EG",[55,58],{"name":56,"role":39,"phone":45,"phoneExt":41,"email":57},"SHERIF MOWAFY, MD","SHERIFMOWAFY2012@GMAIL.COM",{"name":59,"role":39,"phone":60,"phoneExt":41,"email":29},"Sherine Abd Ellatif, MD","01007948840",{"type":62,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"PRINCIPAL_INVESTIGATOR","Dina Abdelhameed Elsadek Salem","principle investigator","100574425","comparison-between-fentanyl-and-dexmedetomidine-as-adjuvant-to-bupivacaine-in-combined-ipack-and-adductor-canal-block-for-postoperative-analgesia-after-knee-surgeries-100574425",false,"NCT06759116","Comparison Between Fentanyl and Dexmedetomidine As Adjuvant to Bupivacaine in Combined IPACK and Adductor Canal Block for Postoperative Analgesia After Knee Surgeries","Analgesic Effect of Fentanyl Vs Dexmedetomidine As Adjuvant to Bupivacaine in Combined IPACK and Adductor Canal Block After Knee Surgeries","Inclusion Criteria:\n\n1 - Patient acceptance 2. Cooperative patients 3. Age: ≥21 and 85\\\u003C years' old 4. Sex: both sexes (males or females). 5. Physical status: ASA Ι \\& II\\& Ш. 6. Body Mass Index (BMI): ≤ 35 kg\u002Fm2. 7. Type of operation: elective unilateral knee surgeries (TKA, ACL, knee arthroscopy)\n\nExclusion Criteria:\n\n. Patient with any contraindications of regional blocks (as coagulopathy or local infection at injection site) 2. Patients with known history of allergy to the study drugs (bupivacaine, dexmedetomidine and fentanyl).\n\n3\\. Advanced hepatic, renal, cardiovascular, neurologic and respiratory diseases.\n\n4.Chronic opioid use (more than 3 months or daily oral morphine \\> 5 mg \u002Fday for 1 month)\n\n\\-",true,"ALL","21 Years","85 Years",{"count":77,"type":78},111,"ESTIMATED","INTERVENTIONAL",[81],"NA","This study will be undertaken to compare the analgesic effects of of fentanyl versus dexmedetomidine as adjuvant to bupivacaine in combined IPACK and ACB for pain management after total knee arthroplasty.",[84],"Analgesia, Postoperative",[86,87,88,89,90],"fentanyl","dexamedetomidine","analgesia","IPACK and adductor canal block","knee surgeries","2025-01-12",{"date":93,"type":94},"2025-01-14","ACTUAL",{"date":96,"type":94},"2025-01-10",{"date":98,"type":78},"2025-08-10",{"name":5,"class":6},1]