[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633859":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":33,"locations":42,"responsibleParty":56,"collaborators":23,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":23,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":23,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":45,"whyStopped":23,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Damascus University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Liquid Platelet-Rich Fibrin group","EXPERIMENTAL","This group will consist of 11 patients presenting with excessive gingival display due to upper lip hypermobility. Each patient will undergo lip repositioning surgery, followed by immediate injection of Liquid Platelet-Rich Fibrin after completion of the surgical procedure.",[13],"Other: Liquid Platelet-Rich Fibrin group",{"label":15,"type":10,"description":16,"interventionNames":17},"Low-Level Laser group","This group will consist of 11 patients presenting with excessive gingival display due to upper lip hypermobility. Each patient will undergo lip repositioning surgery, followed by immediate application of low-level laser therapy (LLLT) after completion of the surgical procedure and at 3,7,10, and 14 days after surgery.",[18],"Other: low-level laser group",[20,24],{"type":6,"name":9,"description":21,"armGroupLabels":22,"otherNames":23},"A partial thickness elliptical mucogingival incision was made from the mesial of the central incisor to the mesial of the first molar bilaterally with preservation of the frenulum; vertical height set to twice the excessive gingival display (2:1 ratio), lower margin 1 mm coronal to the mucogingival junction. Epithelium elevated to expose connective tissue (preserving minor salivary glands). Periosteal sutures (4-0 Vicryl, 2-3 per side) placed where connective tissue ≥0.5 mm ; incision edges approximated with simple interrupted 4-0 silk sutures.\n\n20 mL blood collected into additive-free plastic tubes and centrifuged at 300 × g for 5 minutes. The Liquid Platelet-Rich Fibrin layer was aspirated and injected immediately after surgery along incision margins and surrounding tissue at 1 mm depth, multiple points 2-3 mm apart (≈0.1 mL per injection) to achieve homogeneous distribution.",[9],null,{"type":6,"name":25,"description":26,"armGroupLabels":27,"otherNames":23},"low-level laser group","A partial thickness elliptical mucogingival incision was made from the mesial of the central incisor to the mesial of the first molar bilaterally with preservation of the frenulum; vertical height set to twice the excessive gingival display (2:1 ratio), lower margin 1 mm coronal to the mucogingival junction. Epithelium elevated to expose connective tissue (preserving minor salivary glands). Periosteal sutures (4-0 Vicryl, 2-3 per side) placed where connective tissue ≥0.5 mm to ; incision edges approximated with simple interrupted 4-0 silk sutures.\n\nlow-level laser applied to the surgical site (635nm, 200 mW) as part of the post-surgical treatment and at 3,7,10, and 14 days after surgery.",[15],[29],{"name":30,"affiliation":31,"role":32},"Tarek Qasem, DDS MSc PhD","Faculty of Dentistry, Damascus university, Syria.","STUDY_DIRECTOR",[34,38],{"name":30,"role":35,"phone":36,"phoneExt":23,"email":37},"CONTACT","+963 933432778","Tarek2.qasem@damascusuniversity.edu.sy",{"name":39,"role":35,"phone":40,"phoneExt":23,"email":41},"Walaa albarry, DDS","+963 996766302","walaa9.albarry.@damascusuniversity.edu.sy",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":23,"country":48,"countryCode":23,"cosmosGeoPoint":23,"geoPoint":23,"contacts":49},"Faculty of Dentistry, Damascus university , Syria.","RECRUITING","Damascus","Rif-dimashq Governorate","Syria",[50,54],{"name":51,"role":35,"phone":52,"phoneExt":23,"email":53},"Mohammad Younis Hajeer, DDS MSc PhD","+963 940404840","myhajeer@gmail.com",{"name":39,"role":55,"phone":23,"phoneExt":23,"email":23},"PRINCIPAL_INVESTIGATOR",{"type":57,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR","100633859","comparison-between-liquid-fibrin-and-soft-laser-effects-on-healing-and-relapse-after-lip-repositioning-surgery-100633859",false,"NCT07532161","Comparison Between Liquid Fibrin and Soft Laser Effects on Healing and Relapse After Lip Repositioning Surgery","Comparison Between The Effect of Liquid Platelet-Rich Fibrin and Low-Level Laser Therapy on Enhancing Healing and Reducing Relapse After Lip Repositioning Surgery","Inclusion Criteria:\n\n1. Patients of both genders.\n2. Patients presenting with a gummy smile in the maxillary anterior region (more than 3 mm) due to upper lip hypermobility.\n3. Age 18-50 years.\n4. Systemically healthy individuals, classified as ASA physical status I or II according to the American Society of Anesthesiologists (ASA) classification; that is, patients without systemic disease or with mild, well-controlled systemic conditions.\n5. Patients with good oral hygiene, defined as an O'Leary Plaque Index ≤ 40%.\n6. No previous lip repositioning surgery.\n\nExclusion Criteria:\n\n1. Pregnancy and lactation.\n2. Individuals with a previous history of receiving facial Botox or filler injections.\n3. Systemic diseases or conditions that contraindicate the use of local anesthesia.\n4. Any physical condition that impairs the ability to perform proper oral hygiene measures.\n5. Patients who are smokers or alcohol consumers.\n6. Inability or unwillingness to cooperate.\n7. In adequate width of attached gingiva.\n8. Vertical maxillary excess (moderate to severe) requiring orthognathic intervention.\n9. Short upper lip\n10. Gingival display primarily caused by altered passive eruption requiring crown lengthening.","ALL","18 Years","50 Years",{"count":69,"type":70},22,"ESTIMATED","INTERVENTIONAL",[73],"NA","A gummy smile can negatively affect a patient's self-confidence and satisfaction with their appearance, leading many individuals to seek effective esthetic solutions. The etiology of this condition varies and may include vertical maxillary excess, short upper lip, hyperactive upper lip, gingival enlargement, or altered passive eruption.\n\nLip Repositioning Surgery is one of the minimally invasive esthetic surgical procedures used to reduce the amount of gingival display during smiling. Despite its effectiveness, this surgery may be associated with challenges such as pain, swelling, delayed wound healing, and the possibility of postoperative relapse over time, which could compromise both esthetic and functional outcomes.\n\nTo overcome these challenges and enhance surgical outcomes, adjunctive techniques have been introduced to promote healing and determine whether enhancing the biological healing process can reduce the rate of relapse after LRS. Among the most prominent of these are Injectable Platelet-Rich Fibrin (i-PRF) and Low-Level Laser Therapy (LLLT).",[76],"Gummy Smile",[78,79,80,81,82,83,84,85,86,87],"Excessive gingival display","Gummy smile","Lip Repositioning Surgery","Injectable Platelet-Rich Fibrin (i-PRF)","Liquid Platelet-Rich Fibrin","Low-Level Laser Therapy (LLLT)","Wound healing","Postoperative relapse","Gingival display reduction","Esthetic dentistry","2026-04-24",{"date":90,"type":91},"2026-04-29","ACTUAL",{"date":93,"type":91},"2026-04-20",{"date":95,"type":70},"2027-01-31",{"name":5,"class":6},1]