[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634903":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":27,"centralContacts":32,"locations":37,"responsibleParty":43,"collaborators":37,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":48,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":37,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":69,"overallStatus":73,"whyStopped":37,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":37},{"fullName":5,"class":6},"Harran University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"PEEP-5 Group","EXPERIMENTAL","Participants in this group will receive mechanical ventilation with a positive end-expiratory pressure (PEEP) level of 5 cmH₂O during lumbar spine surgery in the prone position under total intravenous anesthesia (TIVA). Ventilation will be performed using PCV-VG mode with a target tidal volume of 6-8 mL\u002Fkg predicted body weight and respiratory rate adjusted to maintain normocapnia.",[13],"Device: Mechanical Ventilation (PEEP)",{"label":15,"type":10,"description":16,"interventionNames":17},"PEEP-8 Group","Participants in this group will receive mechanical ventilation with a positive end-expiratory pressure (PEEP) level of 8 cmH₂O during lumbar spine surgery in the prone position under total intravenous anesthesia (TIVA). Ventilation will be performed using PCV-VG mode with a target tidal volume of 6-8 mL\u002Fkg predicted body weight and respiratory rate adjusted to maintain normocapnia.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DEVICE","Mechanical Ventilation (PEEP)","Mechanical ventilation will be applied using pressure-controlled ventilation with volume guarantee (PCV-VG) mode during prone lumbar surgery under total intravenous anesthesia (TIVA). Two different positive end-expiratory pressure (PEEP) levels (5 cmH₂O and 8 cmH₂O) will be used according to group allocation. Tidal volume will be set at 6-8 mL\u002Fkg predicted body weight, and respiratory rate will be adjusted to maintain normocapnia (EtCO₂ 35-40 mmHg).",[9,15],[25,26],"PCV-VG Ventilation","Lung Protective Ventilation",[28],{"name":29,"affiliation":30,"role":31},"Basak Pehlivan, Asoc Prof","Harran University Faculty of Medicine, Department of Anesthesiology","PRINCIPAL_INVESTIGATOR",[33,39],{"name":34,"role":35,"phone":36,"phoneExt":37,"email":38},"Basak Pehlivan, Assoc Prof","CONTACT","5054083199",null,"bpehlivan@harran.edu.tr",{"name":40,"role":35,"phone":41,"phoneExt":37,"email":42},"Veli F Pehlivan, MD","5327696566","vfpehlivan@harran.edu.tr",{"type":31,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":37,"oldOrganization":37},"Veli Fahri Pehlivan","Assistant Professor","100634903","comparison-of-5-vs-8-cmho-peep-on-respiratory-mechanics-in-prone-lumbar-surgery-100634903",false,"NCT07545733","Comparison of 5 vs 8 cmH₂O PEEP on Respiratory Mechanics in Prone Lumbar Surgery","The Effect of Different PEEP Levels Accompanied by PCV-VG Mode on Respiratory Mechanics and Gas Exchange in Lumbar Surgeries Performed in the Prone Position Under TIVA","PROPEEP","Inclusion Criteria:\n\n* Patients aged between 18 and 65 years\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Scheduled for elective lumbar spine surgery in the prone position\n* Planned general anesthesia with total intravenous anesthesia (TIVA)\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Body mass index (BMI) ≥ 30 kg\u002Fm²\n* History of significant pulmonary disease (e.g., COPD, asthma)\n* Severe cardiovascular disease\n* Pregnancy\n* Known difficult airway\n* Requirement for intraoperative vasopressor infusion due to hemodynamic instability\n* Conversion to different surgical position or change in surgical plan\n* Incomplete data or protocol deviation","ALL","18 Years","65 Years",{"count":58,"type":59},60,"ESTIMATED","INTERVENTIONAL",[62],"NA","This randomized controlled clinical trial aims to compare the effects of two different positive end-expiratory pressure (PEEP) levels (5 cmH₂O and 8 cmH₂O) on respiratory mechanics in patients undergoing lumbar spine surgery in the prone position under total intravenous anesthesia (TIVA). Prone positioning may adversely affect lung compliance and gas exchange, making optimal ventilatory strategies essential. Driving pressure and mechanical power are considered key determinants of ventilator-induced lung stress. This study will evaluate the impact of different PEEP levels on respiratory parameters and intraoperative physiological changes.",[65,66,67,68],"Lumbar Disc Herniation","Spinal Surgery","Prone Position","General Anesthesia",[70,71,72,25,67,26],"PEEP","Driving Pressure","Mechanical Power","NOT_YET_RECRUITING","2026-04-28",{"date":76,"type":77},"2026-04-29","ACTUAL",{"date":79,"type":59},"2026-05-01",{"date":81,"type":59},"2026-09-03",{"name":5,"class":6}]