[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627206":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":30,"centralContacts":35,"locations":41,"responsibleParty":60,"collaborators":64,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":70,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":30,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":92,"whyStopped":30,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"All India Institute of Medical Sciences, Bhubaneswar","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Accelerated iTBS","EXPERIMENTAL","* Participants will receive aITBS using 100X transcranial magnetic stimulator with 70 mm active cooled figure-of-eight coil\n* Parameters: 3 pulses at 50 Hz bursts, 2 sec on\u002F10 sec off, 3 minutes per session\n* Dosage: 1800 pulses per day (3 rounds separated by 15 min), 5 days\u002Fweek for 4 weeks",[13],"Device: Accelerated iTBS",{"label":15,"type":16,"description":17,"interventionNames":18},"High-Frequency rTMS","ACTIVE_COMPARATOR","* Participants will receive HF-rTMS using 100X transcranial magnetic stimulator with 70 mm active cooled figure-of-eight coil\n* Parameters: 20 Hz pulses, 20 minutes, 4 sec per second, intertrain interval 20 sec, 110% RMT\n* Dosage: 5 sessions per week for 4 weeks",[19],"Device: High-Frequency rTMS",{"label":21,"type":22,"description":23,"interventionNames":24},"Sham rTMS","SHAM_COMPARATOR","* Participants will receive sham stimulation using identical-appearing sham coil\n* Same session schedule and positioning as active groups but without therapeutic magnetic field",[25],"Device: Sham rTMS",[27,31,33],{"type":28,"name":9,"description":11,"armGroupLabels":29,"otherNames":30},"DEVICE",[9],null,{"type":28,"name":15,"description":17,"armGroupLabels":32,"otherNames":30},[15],{"type":28,"name":21,"description":23,"armGroupLabels":34,"otherNames":30},[21],[36],{"name":37,"role":38,"phone":39,"phoneExt":30,"email":40},"Debadatta Mohapatra, MD","CONTACT","+91 9437658251","psych_debadatta@aiimsbhubaneswar.edu.in",[42],{"facility":43,"status":30,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"AIIMS Bhubaneswar","Bhubaneswar","Odisha","751019","India","IN",{"type":50,"coordinates":51},"Point",[52,53],85.83385,20.27241,{"lat":53,"lon":52},[56],{"name":57,"role":38,"phone":58,"phoneExt":30,"email":59},"Exucutive Director, MD","+91 0674-2476083","director@aiimsbhubaneswar.edu.in",{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Dr. Debadatta Mohapatra","Associate Officer",[65],{"name":66,"class":67},"Indian Council of Medical Research","OTHER_GOV","100627206","comparison-of-accelerated-intermittent-theta-burst-stimulation-vs-high-frequency-transcranial-magnetic-stimulation-hf-rtms-on-cognitivesymptoms-in-treatment-resistant-schizophrenia-100627206",false,"NCT07445620","Comparison of Accelerated Intermittent Theta Burst Stimulation vs High Frequency Transcranial Magnetic Stimulation (Hf-rTMS) on Cognitivesymptoms in Treatment-resistant Schizophrenia","Comparison of Accelerated Intermittent Theta Burst Stimulation vs High Frequency Transcranial Magnetic Stimulation (Hf-rTMS) on Cognitivesymptoms in Treatment-resistant Schizophrenia: DB-RCT","DB RCT","Inclusion Criteria:\n\n* Diagnosed with treatment-resistant schizophrenia according to TRIIP Consensus criteria\n* Age: 18-60 years\n* Currently receiving clozapine treatment for at least 6 months\n* Attending psychiatry outpatient department at AIIMS Bhubaneswar\n\nExclusion Criteria:\n\n* Currently receiving or recently received ECT\u002FrTMS\u002FtDCS\n* Co-morbid psychiatric, major medical, or neurological disorders\n* History of withdrawal seizures, delirium tremens, or significant head injury\n* Presence of pacemaker or metal in any part of body (excluding mouth)\n* Pregnant or lactating women","ALL","18 Years","60 Years",{"count":80,"type":81},90,"ESTIMATED","INTERVENTIONAL",[84],"NA","This randomized, double-blind, sham-controlled trial compares three brain stimulation approaches-accelerated intermittent theta burst stimulation (aITBS), high-frequency repetitive transcranial magnetic stimulation (HF-rTMS), and sham stimulation-for treating cognitive deficits in treatment-resistant schizophrenia. Ninety patients receiving clozapine will be randomized 1:1:1 to receive 20 sessions over 4 weeks targeting the dorsolateral prefrontal cortex. The primary outcome is change in cognitive function measured by B-CATS score at 2, 4, and 12 weeks. Secondary outcomes include social cognition, symptom severity, brain metabolism (FDG-PET), and inflammatory biomarkers.",[87,88],"Psychosis","Schizophrenia Disorder",[90,91],"rTMS","Cognitive deficit","NOT_YET_RECRUITING","2026-02-27",{"date":95,"type":96},"2026-03-03","ACTUAL",{"date":98,"type":81},"2026-02-15",{"date":100,"type":81},"2029-12-14",{"name":5,"class":6},1]