[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624458":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":35,"responsibleParty":52,"collaborators":24,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":24,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":24,"overallStatus":75,"whyStopped":24,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Armed Forces Institute of Dentistry, Pakistan","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"ARM 1 : 2%Lignocaine 1:80,000 epinephrine","ACTIVE_COMPARATOR",": 2% Lignocaine Inferior Alveolar Nerve Block (IANB) Participants in this group will receive an inferior alveolar nerve block using 2% Lignocaine with 1:80,000 epinephrine.",[13],"Other: INTERVENTION 1: 2% Lignocaine 1:80,000 epinephrine",{"label":15,"type":10,"description":16,"interventionNames":17},"ARM 2 : 4% Articaine with 1:100,000 epinephrine","Participants in this group will receive 4% Articaine with 1:100,000 epinephrine at the site of the mandibular first molar.",[18],"Other: INTERVENTION 2 : 4%Articaine 1:100,000 epinephrine",[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"INTERVENTION 1: 2% Lignocaine 1:80,000 epinephrine","2% Lignocaine Inferior Alveolar Nerve Block (IANB) : Participants in this group will receive an inferior alveolar nerve block using 2% Lignocaine with 1:80,000 epinephrine. The injection will be administered following standard IANB technique for mandibular first molars. The anesthetic efficacy will be assessed with 2 consecutive non responsive readings on EPT objectivelt and via Heft-Parker VAS not more than ≥55 .",[9],null,{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"INTERVENTION 2 : 4%Articaine 1:100,000 epinephrine","Participants in this group will receive a buccal infiltration of 4% Articaine with 1:100,000 epinephrine at the site of the mandibular first molar. The injection will follow standard buccal infiltration technique. Anesthetic efficacy will be evaluated during endodontic treatment using the same pain assessment method as Arm 1.",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":24,"email":34},"Dr. Sadia Shehzadi Dr. Sadia Shehzadi, BDS,FCPS(PG3)","CONTACT","03342073051","sadiashehzadi321@gmail.com",[36],{"facility":37,"status":24,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Armed Forces Institute of Dentistry AFID CMH Rawalpindi","Rawalpindi","Punjab Province","46000","Pakistan","PK",{"type":44,"coordinates":45},"Point",[46,47],73.0479,33.59733,{"lat":47,"lon":46},[50],{"name":51,"role":32,"phone":24,"phoneExt":24,"email":34},"Sadia Shehzadi",{"type":53,"investigatorFullName":51,"investigatorTitle":54,"investigatorAffiliation":55,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Dr. Sadia Shehzadi","Armed Forces Post Graduate Medical Institute (AFPGMI), Rawalpindi","100624458","comparison-of-anesthetic-efficacy-of-2-lidocaine-inferior-alveolar-nerve-ianb-block-versus-primary-buccal-infilteration-with-4-articaine-in-symptomatic-irreversible-pulpitissip-in-mandibular-first-molars-100624458",false,"NCT07409896","Comparison of Anesthetic Efficacy OF 2% Lidocaine Inferior Alveolar Nerve (IANB) Block Versus Primary Buccal Infilteration With 4% Articaine in Symptomatic Irreversible Pulpitis(SIP) IN Mandibular First Molars","IANB SIP EPT","Inclusion Criteria:\n\n* Systemically healthy patients classified as ASA I, aged 18-55 years.\n* Permanent mandibular first molar tooth requiring endodontic therapy.\n* Diagnosed with symptomatic irreversible pulpitis without swelling or sinus.\n* Normal periapical radiographic appearance (no evidence of periapical pathology).\n* Moderate pain as assessed by the Heft-Parker VAS (\\>54 mm and \\\u003C114 mm).\n* Lingering pain or prolonged response to cold testing (lasting more than 10 seconds).\n* Positive response to electric pulp testing.\n* Outcome assessed must be pulpal anesthesia\n\nExclusion Criteria:\n\n* • Pregnant or lactating mothers.\n\n  * Teeth with reversible pulpitis, previously treated, or with calcified canals.\n  * Teeth with severe periodontal disease or periapical radiolucency.\n  * Patients who have taken analgesics or anti-inflammatory drugs within 6 hours before the treatment visit.\n  * Patients on medications that could potentially interact with the anesthetic solution (e.g., antihypertensives, anticoagulants).\n  * History of allergy to 4% articaine, lidocaine, or epinephrine.\n  * Systemic diseases, immunocompromised states, or significant anxiety\u002Fmental health disorders.\n  * History of vasovagal syncope on local anesthetic administration","ALL","18 Years","55 Years",{"count":67,"type":68},330,"ESTIMATED","INTERVENTIONAL",[71],"NA","This randomized controlled trial aims to compare the anesthetic efficacy of 2% lignocaine administered through an inferior alveolar nerve block (IANB) in one group of participants with 4% articaine delivered via primary buccal infiltration in other group in patients with symptomatic irreversible pulpitis in mandibular first molars.",[74],"Anesthetic Efficacy","NOT_YET_RECRUITING","2026-02-07",{"date":78,"type":79},"2026-02-13","ACTUAL",{"date":81,"type":68},"2026-02-01",{"date":83,"type":68},"2027-02-01",{"name":5,"class":6},1]