[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628336":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":31,"centralContacts":39,"locations":31,"responsibleParty":45,"collaborators":31,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":31,"eligibilityCriteria":53,"healthyVolunteers":49,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":31,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":31,"overallStatus":70,"whyStopped":31,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":31},{"fullName":5,"class":6},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"TIVA-P + PNB","EXPERIMENTAL","The anesthesia method was intravenous anesthesia combined with peripheral nerve block.",[13],"Procedure: Total intravenous anesthesia combined with peripheral nerve block (TIVA + PNB) group",{"label":15,"type":16,"description":17,"interventionNames":18},"GA + PNB","ACTIVE_COMPARATOR","The anesthesia method was general anesthesia plus peripheral nerve block.",[19],"Procedure: General anesthesia combined with peripheral nerve block (GA + PNB) group",{"label":21,"type":16,"description":22,"interventionNames":23},"Spinal anesthesia","The method of anesthesia was spinal anesthesia.",[24],"Procedure: Spinal anesthesia",[26,32,36],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"PROCEDURE","Total intravenous anesthesia combined with peripheral nerve block (TIVA + PNB) group","Preoperatively, all patients received ultrasound-guided peripheral nerve blocks using 0.375% ropivacaine, with a total volume of 30 mL:\n\n20 mL was administered to the popliteal sciatic nerve, and 10 mL to the saphenous nerve.\n\nThe success of the nerve block was determined by the attending anesthesiologist.\n\nSubsequently, total intravenous anesthesia (TIVA) was induced and maintained. Induction was performed with propofol 1.0-2.0 mg\u002Fkg IV bolus, and maintenance was achieved using continuous infusion of propofol at 4.8-12 mg\u002Fkg\u002Fh, with optional co-administration of dexmedetomidine for sedation.\n\nInfusion rates were titrated by the anesthesiologist based on clinical parameters and surgical requirements.",[9],null,{"type":27,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"General anesthesia combined with peripheral nerve block (GA + PNB) group","Similarly, patients received ultrasound-guided peripheral nerve blocks preoperatively, using 0.375% ropivacaine with a total volume of 30 mL:\n\n20 mL was injected around the popliteal sciatic nerve and 10 mL around the saphenous nerve.\n\nThe effectiveness of the block was assessed by the attending anesthesiologist.\n\nGeneral anesthesia (intravenous-inhalational or balanced anesthesia) was then induced with midazolam 1-2 mg, sufentanil 20-30 µg, etomidate 12-18 mg, and rocuronium 35-40 mg.\n\nMaintenance was achieved with sevoflurane inhalation at 0.5-2.5 vol%, in combination with continuous intravenous infusions of propofol (360-600 mg\u002Fh) and remifentanil (360-900 µg\u002Fh).\n\nDosages were dynamically adjusted by the anesthesiologist based on hemodynamic parameters and anesthetic depth.",[15],{"type":27,"name":21,"description":37,"armGroupLabels":38,"otherNames":31},"Spinal anesthesia was performed via subarachnoid block at the L3-L4 or L4-L5 interspace, using 0.75% ropivacaine 2.5-3.5 mL (approximately 18-26 mg).\n\nIf intraoperative sedation was required, propofol was continuously infused after confirmation of adequate anesthetic level, with the infusion discontinued before the end of surgery. Sedation depth was titrated by the anesthesiologist according to patient comfort and safety.\n\nIf anesthesia or sedation was insufficient to ensure surgical safety or completion of the procedure, rescue conversion to general anesthesia was permitted based on clinical judgment. Such events were recorded as perioperative adverse events and protocol deviations, and included in safety and protocol adherence analyses.\n\nAfter surgery, all patients were transferred to the post-anesthesia care unit (PACU) for recovery. Patients were discharged to the general ward once they achieved an Aldrete score ≥9. For spinal anesthesia patients, discharge from PACU required a regr",[21],[40],{"name":41,"role":42,"phone":43,"phoneExt":31,"email":44},"zongyou Pan, Doctoral degree","CONTACT","86+19857004757","panzongyou@gmail.com",{"type":46,"investigatorFullName":31,"investigatorTitle":31,"investigatorAffiliation":31,"oldNameTitle":31,"oldOrganization":31},"SPONSOR","100628336","comparison-of-anesthetic-techniques-for-early-recovery-after-ankle-arthroscopy-100628336",false,"NCT07460310","Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy","Comparison of Total Intravenous, Balanced, and Spinal Anesthesia for Early Recovery Following Ankle Arthroscopy: A Multicenter, Prospective, Randomized Controlled Trial.","Inclusion Criteria:\n\n* Full understanding of the study procedures and methods, with a signed written informed consent form.\n* Aged 18 to 65 years, of either sex.\n* Scheduled for elective unilateral minimally invasive ankle surgery.\n* American Society of Anesthesiologists (ASA) physical status classification I or II.\n* Body Mass Index (BMI) between 16 and 32 kg\u002Fm\\^2\n\nExclusion Criteria:\n\n* Known hypersensitivity or allergy to any study medications or existing contraindications to anesthesia.\n* Chronic obstructive pulmonary disease (COPD) or unstable asthma.\n* History of difficult airway management, poorly controlled gastroesophageal reflux disease (GERD), or a known risk of aspiration.\n* Anticipated surgical duration exceeding 3 hours.\n* History of chronic preoperative opioid use or dependence.\n* History of severe postoperative adverse reactions (e.g., severe postoperative nausea and vomiting).\n* Pregnancy or lactation.\n* History of seizure disorders or epilepsy.\n* Severe peripheral neuropathy.\n* Any other condition that, in the opinion of the investigator, would preclude safe participation in the study.","ALL","18 Years","65 Years",{"count":58,"type":59},200,"ESTIMATED","INTERVENTIONAL",[62],"NA","Ankle arthroscopy is increasingly performed as a day-case procedure, making rapid recovery and efficient discharge critical. Anesthetic technique substantially influences postoperative recovery, yet high-quality evidence comparing anesthetic strategies in ankle arthroscopy is limited.\n\nThis multicenter randomized trial compares total intravenous anesthesia with propofol plus peripheral nerve block (PNB), general anesthesia plus PNB, and spinal anesthesia, with PACU-I recovery time as the primary outcome. Secondary outcomes include postoperative pain, opioid consumption, hospital length of stay, adverse events, recovery quality, satisfaction, limb weakness, and intraoperative hemodynamics.",[65,66,67,68,69],"Ankle Sprain","Ankle (Ligaments); Instability (Old Injury)","Pain Management","ERAS","Ankle Arthroscopy","NOT_YET_RECRUITING","2026-03-04",{"date":73,"type":74},"2026-03-10","ACTUAL",{"date":76,"type":59},"2026-03-01",{"date":78,"type":59},"2026-12-30",{"name":5,"class":6}]