[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100588191":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":14,"centralContacts":22,"locations":10,"responsibleParty":32,"collaborators":10,"id":35,"slug":36,"hasResults":37,"nctId":38,"briefTitle":39,"officialTitle":40,"acronym":10,"eligibilityCriteria":41,"healthyVolunteers":42,"sex":43,"minAge":44,"maxAge":45,"enrollmentInfo":46,"targetDuration":10,"studyType":49,"phases":10,"briefSummary":50,"conditions":51,"keywords":57,"overallStatus":65,"whyStopped":10,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":10},{"fullName":5,"class":6},"Kırıkkale University","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"healthy pulp group",null,"Minimum 35 participants Procedure: Collection of GCF samples using periopaper. Collection of dentinal fluid using cellulose membrane. Collection of pulp tissue samples using a tirnerf.",{"label":13,"type":10,"description":11,"interventionNames":10},"irreversible pulp group",[15,19],{"name":16,"affiliation":17,"role":18},"TANSU M BEŞPARMAK, PhD student","Kirikkale University, Faculty of Dentistry","PRINCIPAL_INVESTIGATOR",{"name":20,"affiliation":17,"role":21},"ALİ ERDEMİR, PROF","STUDY_CHAIR",[23,28],{"name":24,"role":25,"phone":26,"phoneExt":10,"email":27},"ALİ ERDEMİR, PROF.","CONTACT","+905325650065","erdemirali@hotmail.com",{"name":29,"role":25,"phone":30,"phoneExt":10,"email":31},"TANSU M BEŞPARMAK","+905398973940","tansumervebesparmak@gmail.com",{"type":18,"investigatorFullName":33,"investigatorTitle":34,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Ali Erdemir","Professor doctor","100588191","comparison-of-aquaporin--4--5--9-and-il-8-levels-in-gcf-dentin-fluid-and-pulp-samples-100588191",false,"NCT06938191","Comparison of Aquaporin -4, -5, -9 and IL-8 Levels in GCF, Dentin Fluid and Pulp Samples","Comparison of Aquaporin -4, -5, -9 and IL-8 Levels in Gingival Crevicular Fluid, Dentin Fluid and Pulp Samples of Healthy and Acute Irreversible Pulpitis Teeth","Inclusion Criteria:\n\n* Patients aged 18 to 64 years.\n* Patients without any known systemic disease.\n* Patients requiring root canal treatment for prosthetic purposes (Healthy pulp group).\n* Patients with third molars (wisdom teeth) indicated for extraction due to orthodontic or other clinical reasons (Healthy pulp group).\n* Patients diagnosed with symptomatic irreversible pulpitis based on the criteria established by the American Association of Endodontists (AAE) (Symptomatic irreversible pulpitis group).\n* Patients scheduled for routine root canal treatment at the Department of Endodontics, Faculty of Dentistry, Kırıkkale University.\n* Patients who have provided written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Patients with any known systemic disease.\n* Pregnant women or those suspected of being pregnant.\n* Patients who have used antibiotics, anti-inflammatory drugs, or antidepressants within the past 4 weeks.\n* Patients with significant dental plaque or calculus, gingival redness or bleeding, severe gingivitis, generalized periodontitis, or periodontal pockets deeper than 4 mm.\n* Patients with teeth showing internal or external root resorption.\n* Patients for whom complete rubber dam isolation cannot be achieved.\n* Patients with teeth exhibiting signs of necrosis, apical lesions, swelling, or presence of a sinus tract.\n* Patients with immature teeth presenting open apices.\n* Patients with third molars (wisdom teeth) that are not fully erupted or have been previously diagnosed with pericoronitis.",true,"ALL","18 Years","64 Years",{"count":47,"type":48},70,"ESTIMATED","OBSERVATIONAL","This study aimed to compare the changes in AQP -4, -5, -9, and IL-8 levels in pulp tissue, GCF, and dentin fluid samples routinely obtained during the treatment of healthy and symptomatic teeth diagnosed with irreversible pulpitis and investigate whether there is a correlation between them.\n\nA total of 70 patients aged 18-64 years with healthy (Group 1) and symptomatic irreversible pulpitis (Group 2) diagnosed at Kırıkkale University, Faculty of Dentistry, Department of Endodontics who will undergo routine root canal treatment will be included in the study, with a minimum of 35 participants for each group. Before starting treatment, DOS samples will be taken from healthy, symptomatic, irreversible pulpitis-diagnosed teeth and teeth contralateral to these teeth. A dentin fluid sample will be taken by holding the membrane on the dentin surface, and the pulp tissue will be removed and transferred to Eppendorf tubes. The treatment process will be completed by applying routine root canal procedures to the teeth. The samples' Aquaporin -4, -5, -9, and IL-8 levels will be analyzed by specific enzyme-linked immunosorbent assay (ELISA).",[52,53,54,55,56],"Pulpitis","Pulpitis - Irreversible","Pulp Inflammation","Healthy Pulp","Biomarkers",[58,59,60,61,62,63,64],"healthy pulp","pulpitis","irreversible pulpitis","aquaporin-4","IL-8","aquaporin-5","aquaporin-9","NOT_YET_RECRUITING","2025-11-27",{"date":68,"type":69},"2025-12-01","ACTUAL",{"date":71,"type":48},"2025-12",{"date":73,"type":48},"2026-09-12",{"name":5,"class":6}]