[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611571":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":32,"centralContacts":43,"locations":52,"responsibleParty":66,"collaborators":69,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":74,"sex":80,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":23,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":93,"overallStatus":54,"whyStopped":23,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"Kafrelsheikh University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Demineralized Allogeneic Dentin Graft","EXPERIMENTAL","After atraumatic tooth extraction, the socket is filled with demineralized allogeneic dentin particulate graft. The material is processed and sterilized according to standardized laboratory protocols. A resorbable collagen dressing is placed over the graft, followed by site closure. This arm evaluates the regenerative effectiveness of demineralized dentin on ridge preservation.",[13],"Biological: Demineralized Allogeneic Dentin Graft",{"label":15,"type":10,"description":16,"interventionNames":17},"Mineralized Allogeneic Dentin Graft","Following atraumatic extraction, the socket is grafted with mineralized allogeneic dentin particulate material processed and sterilized under controlled conditions. A resorbable collagen dressing is applied prior to closure. This arm assesses the ridge preservation outcomes produced by the mineralized form of dentin graft.",[18],"Biological: Mineralized Allogeneic Dentin Graft",{"label":20,"type":21,"description":22,"interventionNames":23},"Control: Spontaneous Healing (Empty Socket)","NO_INTERVENTION","Participants in this arm undergo atraumatic tooth extraction followed by natural socket healing without graft placement. The socket is allowed to heal spontaneously to serve as the control for evaluating dimensional bone changes relative to grafted groups.",null,[25,29],{"type":26,"name":9,"description":27,"armGroupLabels":28,"otherNames":23},"BIOLOGICAL","Particulate demineralized allogeneic dentin processed from donor teeth using standardized laboratory protocols, including cleaning, defatting, demineralization, dehydration, freeze-drying, and sterilization. The graft is placed into the extraction socket following atraumatic extraction, covered with a resorbable collagen dressing, and the site is closed to promote alveolar ridge preservation.",[9],{"type":26,"name":15,"description":30,"armGroupLabels":31,"otherNames":23},"Particulate mineralized allogeneic dentin derived from processed donor teeth. The dentin is cleaned, defatted, ultrasonically treated, dehydrated, freeze-dried, and sterilized while retaining its mineral phase. The graft is inserted into the extraction socket after atraumatic extraction and covered with a resorbable collagen material prior to closure to support ridge preservation.",[15],[33,37,40],{"name":34,"affiliation":35,"role":36},"Enas Elgendy, PhD","Faculty of Dentistry, Kafrelsheikh University","STUDY_CHAIR",{"name":38,"affiliation":35,"role":39},"Ahmed Elgendy, PhD","PRINCIPAL_INVESTIGATOR",{"name":41,"affiliation":42,"role":39},"Abir El-Mouelhy, PhD","National Research Centre, Cairo, Egypt",[44,49],{"name":45,"role":46,"phone":47,"phoneExt":23,"email":48},"Ahmed Abdelaziz, BDS, MSc candidate","CONTACT","+201157315278","ahmed.mousa@den.kfs.edu.eg",{"name":34,"role":46,"phone":50,"phoneExt":23,"email":51},"+201003508797","enas_ahmed@den.kfs.edu.eg",[53],{"facility":35,"status":54,"city":55,"state":23,"zip":23,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"RECRUITING","Kafr ash Shaykh","Egypt","EG",{"type":59,"coordinates":60},"Point",[61,62],30.93991,31.11174,{"lat":62,"lon":61},[65],{"name":45,"role":46,"phone":47,"phoneExt":23,"email":48},{"type":39,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Ahmed Abdelhamid Musa Abdelaziz","Master's Student, Department of Periodontology, Faculty of Dentistry, Kafrelsheikh University",[70],{"name":71,"class":6},"National Research Centre, Egypt","100611571","comparison-of-demineralized-and-mineralized-dentin-grafts-in-ridge-preservation-100611571",false,"NCT07242313","Comparison of Demineralized and Mineralized Dentin Grafts in Ridge Preservation","Comparative Study Between Demineralized and Mineralized Allogeneic Dentin Grafts for Alveolar Ridge Preservation: A Randomized Controlled Clinical Trial","DDG-ARP","Inclusion Criteria:\n\nAdults aged 18 to 60 years.\n\nMedically healthy patients classified as ASA I.\n\nPresence of a single non-restorable tooth indicated for extraction in the posterior maxilla.\n\nAdequate oral hygiene, with plaque and bleeding indices both below 20%.\n\nSufficient bone volume to allow socket preservation without requiring simultaneous augmentation.\n\nPatients willing to participate in the study and able to provide written informed consent.\n\nAbility to commit to follow-up visits for up to 6 months.\n\nExclusion Criteria:\n\nSmokers or tobacco users of any form.\n\nPresence of uncontrolled systemic diseases (e.g., uncontrolled diabetes).\n\nConditions affecting bone metabolism (e.g., osteoporosis, long-term corticosteroid therapy).\n\nPregnant or lactating women.\n\nHistory of radiotherapy in the head and neck region.\n\nActive infection or suppuration at the extraction site.\n\nImmunocompromised patients or those on immunosuppressive therapy.\n\nPatients taking medications known to impair healing (e.g., bisphosphonates).\n\nAllergy or hypersensitivity to any study-related materials.","ALL","18 Years","60 Years",{"count":84,"type":85},45,"ESTIMATED","INTERVENTIONAL",[88],"NA","This clinical investigation aims to assess how two different allogeneic dentin graft materials - one de-mineralized and the other mineralized - influence bone preservation following extraction of a single upper posterior tooth. A total of 45 patients will be randomly allocated into three equal groups: a socket-only spontaneous healing group (control), a de-mineralized dentin graft group, and a mineralized dentin graft group. Over a six-month period after extraction, measurements will be taken using CBCT to monitor changes in ridge width, height, and bone density. Secondary outcomes include patient-reported pain, postoperative swelling, satisfaction levels, width of keratinized tissue, and histomorphometric data from biopsy samples at implant placement. Findings from this trial may support evidence-based decisions in alveolar ridge preservation and help clinicians choose the most predictable grafting strategy before implant placement.",[91,92],"Alveolar Ridge Preservation","Post Extraction Alveolar Bone Resorption",[91,94,95,96,97,98,99,100,101],"Socket Preservation","Post-Extraction Bone Loss","Dentin Graft","Allogeneic Dentin","Demineralized Dentin Matrix","Mineralized Dentin Graft","Bone Regeneration","Histomorphometry","2025-11-21",{"date":104,"type":105},"2025-11-24","ACTUAL",{"date":107,"type":105},"2025-10-21",{"date":109,"type":85},"2026-08-31",{"name":5,"class":6},1]