[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100602202":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":10,"responsibleParty":18,"collaborators":10,"id":22,"slug":23,"hasResults":24,"nctId":25,"briefTitle":26,"officialTitle":27,"acronym":10,"eligibilityCriteria":28,"healthyVolunteers":24,"sex":29,"minAge":30,"maxAge":10,"enrollmentInfo":31,"targetDuration":34,"studyType":35,"phases":10,"briefSummary":36,"conditions":37,"keywords":44,"overallStatus":52,"whyStopped":10,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":10},{"fullName":5,"class":6},"Gadjah Mada University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"ICU Patients on Mechanical Ventilation >48 Hours",null,"This cohort includes adult patients admitted to the Intensive Care Unit (ICU) who have been on mechanical ventilation for more than 48 hours. Each participant undergoes assessment using both the Rapid Shallow Breathing Index (RSBI) and diaphragm ultrasonography, including measurements of diaphragmatic excursion (DE) and diaphragmatic thickening fraction (DTF). These assessments are conducted prior to extubation to evaluate their predictive accuracy in determining weaning success or failure.",[13],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Meta Restu Synthana, Dr.","CONTACT","6281215621213","meta.restu.synthana@ugm.ac.id",{"type":19,"investigatorFullName":20,"investigatorTitle":21,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Meta Restu Synthana","Fellow in Intensive Care","100602202","comparison-of-diaphragm-ultrasound-and-rsbi-for-predicting-weaning-success-in-mechanically-ventilated-icu-patients-100602202",false,"NCT07120438","Comparison of Diaphragm Ultrasound and RSBI for Predicting Weaning Success in Mechanically Ventilated ICU Patients","Comparison Between Diaphragmatic Ultrasound and Rapid Shallow Breathing Index (RSBI) in Predicting Weaning Success in Patients on Mechanical Ventilation for More Than 48 Hours in the ICU of Dr. Sardjito Hospital, Yogyakarta","Inclusion Criteria:\n\n1. Patients who have been on mechanical ventilation for more than 48 hours\n2. Adult patients aged ≥18 years\n3. Patients who meet the criteria for hemodynamic stability for weaning\n4. Patients or their families have provided written informed consent\n5. Patients with FiO₂ \\\u003C 50%, PEEP level \\\u003C 5 cm H₂O, respiratory rate \\\u003C 30 breaths per minute, PaO₂\u002FFiO₂ \\> 200, and GCS \\> 13\n6. Patients who have successfully completed the Spontaneous Awakening Trial (SAT) and Spontaneous Breathing Trial (SBT)\n\nExclusion Criteria:\n\n1. Patients with neuromuscular disorders, anatomical abnormalities of the diaphragm, or diaphragmatic palsy\n2. Patients with a history of severe thoracic trauma affecting diaphragm function on one or both sides\n3. Pregnancy","ALL","18 Years",{"count":32,"type":33},55,"ESTIMATED","2 Days","OBSERVATIONAL","The goal of this observational study is to evaluate the predictive value of diaphragmatic ultrasound compared to the Rapid Shallow Breathing Index (RSBI) in determining weaning success among mechanically ventilated patients in the ICU for more than 48 hours.\n\nThe main question it aims to answer is:\n\nWhich is more effective in predicting weaning success: diaphragmatic ultrasound (including Diaphragmatic Excursion \\[DE\\] and Diaphragm Thickening Fraction \\[DTF\\]) or RSBI, in patients ventilated \\>48 hours in the ICU of Dr. Sardjito General Hospital, Yogyakarta?\n\nParticipants will be adult ICU patients who are undergoing weaning from mechanical ventilation after more than 48 hours. Before extubation, each participant will undergo diaphragmatic ultrasound assessment to measure DE and DTF, along with RSBI measurement. The predictive accuracy of these parameters will be evaluated by comparing them with the actual weaning outcomes.\n\nSecondary objectives include:\n\n1. Assessing whether diaphragmatic ultrasound is associated with a higher weaning success rate than RSBI.\n2. Evaluating the correlation between DE values and successful weaning.\n3. Determining the optimal cutoff values of DE and DTF as predictors of weaning failure.\n4. Analyzing the incidence of weaning failure in patients who do not meet optimal diaphragm function criteria.\n5. Identifying DE and DTF thresholds that may help reduce the risk of reintubation.",[38,39,40,41,42,43],"Ventilator Weaning","Mechanical Ventilation","Respiratory Insufficiency Requiring Mechanical Ventilation","Weaning From Mechanical Ventilation","Weaning From Mechanical Ventilation in Care Unit","Intensive Care Unit Patients",[45,46,47,48,49,50,51],"Diaphragmatic Ultrasound","Rapid Shallow Breathing Index","Diaphragm Thickening Fraction","Diaphragm Excursion","Weaning Prediction","ICU","Weaning Failure","NOT_YET_RECRUITING","2025-08-06",{"date":55,"type":56},"2025-08-13","ACTUAL",{"date":58,"type":33},"2025-08",{"date":60,"type":33},"2026-03",{"name":5,"class":6}]