[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637538":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":10,"centralContacts":29,"locations":35,"responsibleParty":50,"collaborators":52,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":10,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":78,"studyType":79,"phases":10,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":38,"whyStopped":10,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"RenJi Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"ClotTriever System group",null,"Patients receive percutaneous mechanical thrombectomy by ClotTriever System",[13],"Procedure: Percutaneous mechanical thrombectomy by ClotTriever System",{"label":15,"type":10,"description":16,"interventionNames":17},"Aspiration thrombectomy group","Patients receive percutaneous mechanical thrombectomy by aspiration or rheolytic thrombectomy",[18],"Procedure: Percutaneous mechanical thrombectomy by aspiration or rheolytic thrombectomy",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"PROCEDURE","Percutaneous mechanical thrombectomy by ClotTriever System","The procedure is performed via the ipsilateral popliteal vein access or the ipsilateral femoral vein access. After puncture under fluoroscopic or ultrasound guidance, a vascular sheath is inserted, systemic heparinization is administered, and a guidewire is advanced antegradely into the inferior vena cava with the assistance of a catheter to establish the access. Once the access is established, treatment is carried out using stent retriever devices. Available stent retriever devices include currently marketed options such as ClotTriever (INARI MEDICAL, USA). After thrombectomy, the thrombus removal efficacy is assessed by venography.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"Percutaneous mechanical thrombectomy by aspiration or rheolytic thrombectomy","The procedure is performed via the ipsilateral calf deep vein access, the ipsilateral popliteal vein access, or the ipsilateral femoral vein access. After puncture under fluoroscopic or ultrasound guidance, a vascular sheath is inserted, systemic heparinization is administered, and a guidewire is advanced antegradely into the inferior vena cava with the assistance of a catheter to establish the access. Once the access is established, treatment is carried out using mechanical aspiration thrombectomy devices. Available aspiration thrombectomy devices include currently marketed options such as the AngioJet thrombectomy catheter (Boston Scientific, USA) and the Acostream thrombectomy catheter (Acotec, China). After thrombectomy, the thrombus removal efficacy is assessed by venography.",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},"Qihong Ni","CONTACT","+8615801900772","niqihong1989@163.com",[36],{"facility":37,"status":38,"city":39,"state":10,"zip":10,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Renji hospital","RECRUITING","Shanghai","China","CN",{"type":43,"coordinates":44},"Point",[45,46],121.45806,31.22222,{"lat":46,"lon":45},[49],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},{"type":51,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[53,55,57,59,61,63],{"name":54,"class":6},"Changhai Hospital",{"name":56,"class":6},"Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University",{"name":58,"class":6},"Wenzhou Central Hospital",{"name":60,"class":6},"West China Hospital",{"name":62,"class":6},"Chengdu University of Traditional Chinese Medicine",{"name":64,"class":6},"First People's Hospital of Hangzhou","100637538","comparison-of-different-mechanical-thrombectomy-devices-in-endovascular-treatment-of-acute-iliofemoral-venous-thrombosis-100637538",false,"NCT07622212","Comparison Of Different Mechanical Thrombectomy Devices in Endovascular Treatment of Acute Iliofemoral Venous Thrombosis","Comparison Of Different Mechanical Thrombectomy Devices in Endovascular Treatment of Acute Iliofemoral Venous Thrombosis (The COMET Study)","Inclusion Criteria:\n\n1. Aged between 18 and 85 years;\n2. Diagnosed with acute iliofemoral venous thrombosis, with thrombosis involving at least the iliac vein and common femoral vein;\n3. Time from symptom onset to endovascular treatment ≤ 14 days;\n4. Patients undergo endovascular treatment with percutaneous mechanical thrombectomy;\n5. Patients sign the informed consent form.\n\nExclusion Criteria:\n\n1. Presence of PTS in the limb to be treated in this procedure, or a history of symptomatic DVT in the same limb within the past 2 years;\n2. Concurrent symptomatic acute DVT involving the iliac vein and\u002For common femoral vein in the contralateral limb;\n3. Known allergy to heparin, low molecular weight heparin, contrast agents, etc.\n4. Concomitant severe pulmonary embolism with hemodynamic changes, such as hypoxia, hypotension, etc.\n5. Inability to tolerate endovascular treatment due to conditions such as acute systemic illness, severe dyspnea, etc.\n6. Concomitant severe renal insufficiency with creatinine clearance \\\u003C 30 ml\u002Fmin;\n7. Concomitant active bleeding, severe hepatic insufficiency, bleeding tendency, etc.\n8. Concomitant severe anemia (hemoglobin \\\u003C 8.0 mg\u002FdL) or platelet count \\\u003C 80,000\u002FmL;\n9. History of subarachnoid hemorrhage, intracranial hemorrhage, intracranial vascular malformation, or intracranial aneurysm;\n10. Pregnant women;\n11. Presence of other diseases (e.g., advanced malignancy, cardiac insufficiency, etc.) with an expected life expectancy \\\u003C 24 months\n12. Participation in any drug or medical device clinical trial that may interfere with this study within the past 1 month;\n13. Patients unwilling to participate in this trial.","ALL","18 Years","85 Years",{"count":76,"type":77},180,"ESTIMATED","24 Months","OBSERVATIONAL","A head-to-head comparison of two different types of percutaneous mechanical thrombectomy (PMT) - ClotTriever System versus aspiration thrombectomy (including rheolytic thrombectomy) - in patients with acute iliofemoral deep vein thrombosis (DVT) was conducted to determine whether ClotTriever System can improve thrombus clearance rate, reduce the incidence of post-thrombotic syndrome (PTS), and enhance the long-term efficacy of endovascular treatment for acute iliofemoral DVT.",[82],"Deep Vein Thrombosis",[84,85,86],"Deep venous thrombosis","Percutaneous mechanical thrombectomy","Post-thrombotic syndrome","2026-05-26",{"date":89,"type":90},"2026-06-03","ACTUAL",{"date":92,"type":90},"2024-01-01",{"date":94,"type":77},"2028-12-31",{"name":5,"class":6},1]