[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100576081":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":34,"responsibleParty":44,"collaborators":24,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":24,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":24,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":24,"overallStatus":67,"whyStopped":24,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Indonesia University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A ( Triple combination Group)","EXPERIMENTAL","Group A, The treatment group, getting sunscreen cream in the morning and triple combination flucinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05% cream at night and facial soap that can be used in the morning and evening.",[13],"Drug: Triple combination cream",{"label":15,"type":10,"description":16,"interventionNames":17},"Group B (Triple Combination Group)","Group B, the treatment group, getting sunscreen cream in the morning and triple combination of mometasone furoate 0.1%, hydroquinone 4%, tretinoin 0.05%, cream at night and facial soap that can be used in the morning and evening.",[13],[19,25],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","Triple combination cream","1. Apply sunscreen SPF ≥30 in the morning on 2 knuckles\n2. Apply triple combination cream containing hydroquinone 40 mg, tretinoin 0.5 mg, and fluocinolone acetonide 0.1 mg at night all over the face except the area around the eyes, 1 fingertip unit (FTU) or 1 knuckle.",[9],null,{"type":20,"name":21,"description":26,"armGroupLabels":27,"otherNames":24},"1. Apply sunscreen SPF ≥30 in the morning on 2 knuckles\n2. Apply triple combination cream containing mometasone furoate 0.1%, hydroquinone 4%, tretinoin 0.05% at night all over the face except the area around the eyes, 1 fingertip unit (FTU) or 1 knuckle",[15],[29],{"name":30,"role":31,"phone":32,"phoneExt":24,"email":33},"Prof. Dr. dr. Irma Bernadette S. Sitohang, SpKK(K)","CONTACT","+62818130761","irma_bernadette@yahoo.com",[35],{"facility":36,"status":24,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":24,"geoPoint":24,"contacts":42},"Dr. Cipto Mangunkusumo Hospital","Central Jakarta","DKI Jakarta","10430","Indonesia","ID",[43],{"name":30,"role":31,"phone":32,"phoneExt":24,"email":33},{"type":45,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Dr.dr.Irma Bernadette, SpKK (K)","Prof. Dr. dr. Irma Bernadette S. Sitohang, Sp.DVE, Subsp. D.K.E","100576081","comparison-of-effectiveness-and-safety-of-triple-combination-cream-of-fucinolone-acetonide-001-hydroquinone-4-tretinoin-005-with-mometasone-furoate-01-hydroquinone-4-tretinoin-005-in-the-treatment-of-melasma-100576081",false,"NCT06780644","Comparison of Effectiveness and Safety of Triple Combination Cream of Fucinolone Acetonide 0.01%, Hydroquinone 4%, Tretinoin 0.05% with Mometasone Furoate 0.1%, Hydroquinone 4%, Tretinoin 0.05% in the Treatment of Melasma","Inclusion Criteria:\n\n* Women\n* Diagnosed with melasma based on clinical and Wood's lamp examination\n* 30-59 years old\n* Skin type IV or V\n\nExclusion Criteria:\n\n* Plan to be pregnant and breastfeeding women during the study period ( 12 weeks)\n* using or have used hormonal contraception in the last 6 months, or plan to use hormonal contraception during the study period (12 weeks)\n* Using topical melasma treatments such as corticosteroids, tretinoin, hydroquinone, and other skin whitening or lightening treatments in at least the last 2 weeks.\n* Have used topical therapy for melasma i.e. triple combination cream for at least 3 months and showed no significant improvement.\n* Using systemic therapy for melasma, e.g. antioxidants, tranexamic acid in at least the last 4 weeks.\\*\n* History of eppeeling, laser or mechanical abrasion on the face in the last 6 months.\\*\n* Using photosensitizer drugs such as tetracycline, phenytoin, carbamazepine, and spironolactone in at least the last 4 weeks.\n* Having other skin complaints that may interfere with the evaluation of melasma such as post-inflammatory hyperpigmentation, Hori nevus, Ota nevus, pigmented contact dermatitis, and other pigmentation disorders.\n* Difficulty in adherence to treatment such as long distance from home, work schedules, and busy activities.",true,"FEMALE","30 Years","59 Years",{"count":59,"type":60},56,"ESTIMATED","INTERVENTIONAL",[63],"NA","This Research is a clinical study with a single-blind randomized controlled trial of evaluators. Clinical trial Randomized Controlled Trial (RCT) design that compares the use of a triple combination cream of flucinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05% with a triple cream combination of mometasone furoate 0.1%, hydroquinone 4%, tretinoin 0.05% in melasma therapy in RSCM-FKUI.\n\nThis study aims to Assess the effectiveness and safety of Triple Combination Cream of Fucinolone Acetonide 0.01%, Hydroquinone 4%, Tretinoin 0.05% with Mometasone Furoate 0.1%, Hydroquinone 4%, Tretinoin 0.05% in melasma patients",[66],"Melasma","NOT_YET_RECRUITING","2025-01-13",{"date":70,"type":71},"2025-01-17","ACTUAL",{"date":73,"type":60},"2025-02-17",{"date":75,"type":60},"2025-09-01",{"name":5,"class":6},1]