[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628828":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":33,"locations":44,"responsibleParty":60,"collaborators":24,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":24,"eligibilityCriteria":69,"healthyVolunteers":66,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":24,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":86,"overallStatus":47,"whyStopped":24,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Aswan University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Manual Syringing with 20 mL Syringes.","EXPERIMENTAL","Participants in this arm receive blood products administered manually by clinical staff using 20 mL syringes through 18-gauge peripheral and 16-gauge external jugular cannulae",[13],"Device: Manual syringing",{"label":15,"type":10,"description":16,"interventionNames":17},"Blood transfusion via pneumatic pressure bags set at 300 mmHg","Participants in this arm receive blood products administered using a pneumatic pressure bag inflated to a constant 300 mmHg through 18-gauge peripheral and 16-gauge external jugular cannulae",[18],"Device: pneumatic pressure bag",[20,25],{"type":21,"name":22,"description":11,"armGroupLabels":23,"otherNames":24},"DEVICE","Manual syringing",[9],null,{"type":21,"name":26,"description":16,"armGroupLabels":27,"otherNames":24},"pneumatic pressure bag",[15],[29],{"name":30,"affiliation":31,"role":32},"Mohammed Saeed, lecturer","Aswan University-Faculty of Medicine-New Aswan City","STUDY_CHAIR",[34,40],{"name":35,"role":36,"phone":37,"phoneExt":38,"email":39},"Soudy Hammad, lecturer of anesthesia,SICU,","CONTACT","+201014761523","+201017446683","soudi.salah@aswu.edu.eg",{"name":41,"role":36,"phone":42,"phoneExt":24,"email":43},"Tarek Hemaida, lecturer","+201007363190","dr.tarek@aswu.edu.eg",[45],{"facility":46,"status":47,"city":48,"state":24,"zip":24,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Aswan University Hospital","RECRUITING","Aswān","Egypt","EG",{"type":52,"coordinates":53},"Point",[54,55],32.89942,24.09082,{"lat":55,"lon":54},[58],{"name":59,"role":36,"phone":37,"phoneExt":24,"email":39},"Soudy Hammad, Lecturer",{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Soudy Salah Hammad","lecturer of anesthesia,ICU, pain management","100628828","comparison-of-efficacy-and-safety-of-manual-syringing-versus-pneumatic-pressure-bag-for-blood-transfusion-in-patients-undergoing-cesarean-section-with-major-obstetric-hemorrhage-100628828",false,"NCT07466719","Comparison of Efficacy and Safety of Manual Syringing Versus Pneumatic Pressure Bag for Blood Transfusion in Patients Undergoing Cesarean Section With Major Obstetric Hemorrhage","Inclusion Criteria:\n\n* Women aged 18-45 years undergoing cesarean section\n* Diagnosed major obstetric hemorrhage (blood loss ≥1000 mL or hemodynamic instability requiring transfusion)\n* Written informed consent for participation\n\nExclusion Criteria:\n\n* Pre-existing hemolytic conditions (e.g., sickle cell disease, thalassemia)\n* Known hypersensitivity to blood products\n* Severe baseline coagulopathy (defined as INR \\> 2.0 or Platelet count \\\u003C 50,000\u002Fmm³) or established disseminated intravascular coagulation (DIC) prior to randomization\n* Refusal to receive blood transfusion","FEMALE","18 Years","45 Years",{"count":74,"type":75},50,"ESTIMATED","INTERVENTIONAL",[78],"NA","The goal of this clinical trial is to compare the safety and efficacy of manual syringing versus pneumatic pressure bags for blood transfusion in patients experiencing major obstetric hemorrhage during a cesarean section. It will also evaluate the effectiveness of these methods in rapidly stabilizing patient vital signs. The main questions it aims to answer are:Does manual syringing result in a higher incidence of hemolysis (red blood cell destruction) compared to pneumatic pressure bags?Which method is more effective and faster at achieving hemodynamic stability (restoring normal blood pressure, heart rate, and oxygen levels)?Are there differences between the two methods regarding total blood product usage, transfusion-related complications, and the length of hospital stay?Researchers will compare manual syringing (using 20 mL syringes) to pneumatic pressure bags (inflated to 300 mmHg) to determine which is safer and more efficient for emergency transfusions in resource-constrained environments.Participants will:Be women aged 18-45 years undergoing a cesarean section who are diagnosed with major obstetric hemorrhage (blood loss \\>1000 mL or hemodynamic instability).Be randomly assigned to one of two groups to receive their blood transfusion through either the manual syringe method or a pneumatic pressure bag.Receive standard vascular access through multiple peripheral and jugular cannulae.Undergo close monitoring of vital signs to determine the time to stabilization.Provide blood samples at baseline and six hours post-transfusion to measure markers of hemolysis, specifically Lactate Dehydrogenase (LDH) and indirect bilirubin levels.Be monitored for any transfusion-related complications, such as allergic reactions or acute kidney injury, during their hospital stay and for major complications up to 30 days postoperatively",[81,82,83,84,85],"Obstetric Hemostasis","Intravascular Hemolysis","Major Obstetric Hemorrhage","Manual Syringing Transfusion","Pneumatic Pressure Bag Transfusion",[87,84,85,82],"Major Obstetric Hemorrhage,","2026-03-10",{"date":90,"type":91},"2026-03-12","ACTUAL",{"date":93,"type":91},"2025-09-01",{"date":95,"type":75},"2026-04-01",{"name":5,"class":6},1]