[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640534":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":10,"centralContacts":28,"locations":34,"responsibleParty":48,"collaborators":10,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":10,"eligibilityCriteria":58,"healthyVolunteers":54,"sex":59,"minAge":60,"maxAge":10,"enrollmentInfo":61,"targetDuration":10,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":72,"overallStatus":36,"whyStopped":10,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Istanbul University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Eleveld Model",null,"Eleveld model used patients",[13],"Other: TCI Propofol Injection Models- Eleveld",{"label":15,"type":10,"description":16,"interventionNames":17},"Schnider Model","Schnider model used patients",[18],"Other: TCI Propofol Injection Schnider",[20,24],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"TCI Propofol Injection Models- Eleveld","Patients in this group will receive propofol for anesthetic induction using target-controlled infusion based on the Eleveld pharmacokinetic\u002Fpharmacodynamic model. Standard monitoring will include electrocardiography, peripheral oxygen saturation, invasive arterial blood pressure, heart rate, and bispectral index monitoring. Fentanyl 2 mcg\u002Fkg and rocuronium 0.6 mg\u002Fkg will be administered according to the study protocol. Hemodynamic variables and BIS values will be recorded before induction and at 1, 3, 5, and 10 minutes after induction.",[9],{"type":6,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"TCI Propofol Injection Schnider","Patients randomized to the Schnider group will receive propofol for anesthetic induction using target-controlled infusion based on the Schnider pharmacokinetic\u002Fpharmacodynamic model. Propofol will be administered via a TCI system according to the study protocol. Standard monitoring will include electrocardiography, peripheral oxygen saturation, invasive arterial blood pressure, heart rate, and bispectral index monitoring. Fentanyl 2 mcg\u002Fkg and rocuronium 0.6 mg\u002Fkg will be administered as part of the standardized induction protocol. Hemodynamic variables and BIS values will be recorded before induction and at 1, 3, 5, and 10 minutes after induction.",[15],[29],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},"Tugce Aydin Ozata, MD","CONTACT","009 0533 711 6090","tugceaydin1@gmail.com",[35],{"facility":5,"status":36,"city":37,"state":10,"zip":10,"country":38,"countryCode":10,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"RECRUITING","Istanbul","Turkey (Türkiye)",{"type":40,"coordinates":41},"Point",[42,43],28.94966,41.01384,{"lat":43,"lon":42},[46],{"name":30,"role":31,"phone":47,"phoneExt":10,"email":33},"0090 533 711 6090",{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Tugce Aydin Ozata","MD","100640534","comparison-of-hemodynamic-responses-during-anesthesia-induction-using-eleveld-and-schnider-100640534",false,"NCT07586189","Comparison of Hemodynamic Responses During Anesthesia Induction Using Eleveld and Schnider","Comparison of Hemodynamic Responses During Anesthesia Induction Using Eleveld and Schnider Target-Controlled Infusion Models. A Randomized Trial","Inclusion Criteria:\n\n* Patients scheduled for elective spinal surgery under general anesthesia\n* Patients who will undergo surgery at the Neurosurgery Department of Istanbul University, Istanbul Faculty of Medicine\n* Patients aged 18 years or older\n* Patients who provide written informed consent to participate in the study\n\nExclusion Criteria:\n\n* Patients with uncontrolled hypertension\n* Patients with uncontrolled diabetes mellitus\n* Patients younger than 18 years of age\n* Patients who do not provide informed consent to participate in the study","ALL","18 Years",{"count":62,"type":63},50,"ESTIMATED","OBSERVATIONAL","This randomized prospective study aims to compare the effects of two target-controlled infusion models, the Schnider and Eleveld models, on anesthetic depth and hemodynamic responses during anesthesia induction in adult patients undergoing spinal surgery.\n\nPatients scheduled for spinal surgery will be randomized into either the Schnider or Eleveld group. Before induction, standard monitoring will be applied, including electrocardiography, peripheral oxygen saturation, invasive arterial blood pressure monitoring, heart rate monitoring, and bispectral index monitoring. Anesthesia induction will be performed with fentanyl 2 mcg\u002Fkg, rocuronium 0.6 mg\u002Fkg, and propofol administered by target-controlled infusion with an effect-site target concentration of 3 mcg\u002FmL according to the allocated pharmacokinetic model.\n\nHemodynamic parameters and bispectral index values will be recorded before induction and at the 1st, 3rd, 5th, and 10th minutes after induction. Additional parameters, including time to BIS below 40, time to delta activity, burst suppression duration, total propofol dose during the first 5 minutes, need for additional propofol, hemodynamic response to intubation, vasopressor requirement within the first 10 minutes, and use of esmolol, will also be documented. The primary aim is to evaluate whether the Schnider and Eleveld models differ in terms of induction-related hemodynamic stability and anesthetic depth during the early induction period.",[67,68,69,70,71],"Spinal (Fusion) Surgery","Total Intravenous Anesthesia","Target Controlled Infusion of Propofol","Anesthesia Depth Monitoring","BIS-EEG",[73,74,75,76],"spinal surgery","total intravenous anesthesia","target controlled infusion","anesthesia depth monitoring","2026-05-18",{"date":79,"type":80},"2026-05-20","ACTUAL",{"date":77,"type":80},{"date":83,"type":63},"2026-08-30",{"name":5,"class":6},1]