[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100607057":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":33,"centralContacts":38,"locations":43,"responsibleParty":61,"collaborators":32,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":65,"sex":71,"minAge":72,"maxAge":32,"enrollmentInfo":73,"targetDuration":32,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":46,"whyStopped":32,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Centre Hospitalier Régional d'Orléans","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Sequence A, B, A, B","EXPERIMENTAL","First and third samples with syringe flush; second and fourth with vacuum tube flush",[13],"Procedure: catheter flushing techniques",{"label":15,"type":10,"description":16,"interventionNames":17},"Sequence A, B, B, A","First and fourth samples with syringe flush; second and third with vacuum tube flush",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Sequence B, A, B, A","Second and fourth samples with syringe flush; first and third with vacuum tube flush",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Sequence B, A, A, B","Second and third samples with syringe flush; first and fourth with vacuum tube flush",[13],[27],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"PROCEDURE","catheter flushing techniques","Two catheter flushing techniques will be compared:\n\n* Method A: A 5 mL flush performed with a syringe over 5 seconds.\n* Method B: A 5 mL flush using a vacuum tube (standard discard tube).",[9,15,23,19],null,[34],{"name":35,"affiliation":36,"role":37},"Gregoire MULLER, Dr","CHU Orléans","PRINCIPAL_INVESTIGATOR",[39],{"name":35,"role":40,"phone":41,"phoneExt":32,"email":42},"CONTACT","+33238229534","gregoire.muller@chu-orleans.fr",[44],{"facility":45,"status":46,"city":47,"state":32,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Chu Orleans","RECRUITING","Orléans","45067","France","FR",{"type":52,"coordinates":53},"Point",[54,55],1.90407,47.90248,{"lat":55,"lon":54},[58,60],{"name":59,"role":40,"phone":41,"phoneExt":32,"email":42},"Gregoire MULLER, PH",{"name":59,"role":37,"phone":32,"phoneExt":32,"email":32},{"type":62,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR","100607057","comparison-of-heparin-anti-xa-activity-from-central-venous-catheter-samples-using-a-5-ml-syringe-flush-or-a-vacuum-tube-flush-versus-peripheral-vein-samples-in-icu-patients-100607057",false,"NCT07183605","Comparison of Heparin Anti-Xa Activity From Central Venous Catheter Samples Using a 5 mL Syringe Flush or a Vacuum Tube Flush Versus Peripheral Vein Samples in ICU Patients","Central Catheter Anti-Xa Sampling Study for Accurate aNalysis and Reliable Dosage Assessment","CASSANDRA","Inclusion Criteria:\n\n* Person (or support person\u002Frelative if unable to do so) who has agreed to participate in the study\n* 18 years of age or older\n* Hospitalized in intensive care medicine\n* Having a central venous catheter with at least three lumens (internal jugular, subclavian or femoral) already in place\n* Receiving continuous intravenous unfractionned heparin, with target Anti-Xa activity between 0.3 and 0.7 IU\u002Fml.\n\nExclusion Criteria:\n\n* Protected person (under guardianship or curatorship)\n* Person under court protection\n* Person deprived of liberty\n* Person not affiliated to the French social security\n* Pregnant or breast-feeding woman","ALL","18 Years",{"count":74,"type":75},30,"ESTIMATED","INTERVENTIONAL",[78],"NA","The goal is to investigate whether blood samples drawn from a central venous catheter can provide reliable measurements of unfractionated heparin (UFH) anti-Xa activity, compared to the standard method of peripheral vein puncture, in intensive care unit (ICU) patients receiving continuous intravenous UFH.\n\nTo evaluate the reliability of central venous blood sampling, the study will compare anti-Xa activity levels obtained simultaneously from two different types of blood draws: one from a peripheral vein (reference method), and the other from the central line using one of two flushing techniques.\n\nThe two central flushing techniques being studied are:\n\n* A 5 mL syringe flush performed over 5 seconds, followed by blood collection.\n* A vacuum tube flush that draws and discards 5 mL of blood, followed by blood collection.\n\nEach patient will undergo four pairs of simultaneous blood draws, using both central techniques in a randomized sequence. The main objective is to assess whether the anti-Xa levels from central samples are equivalent to those from peripheral vein puncture, with a predefined margin of equivalence of ±0.05 IU\u002FmL.\n\nFindings from this study may support the use of central venous catheters for routine anti-Xa monitoring in ICU patients, potentially avoiding painful or technically difficult peripheral vein punctures.",[81],"Anticoagulants and Bleeding Disorders",[83,84,85,86,87],"Unfractionated Heparin","Anti-Xa Activity","Catheterization, Central Venous","Blood Specimen Collection","Intensive care","2025-11-24",{"date":90,"type":91},"2025-11-25","ACTUAL",{"date":93,"type":91},"2025-09-22",{"date":95,"type":75},"2026-10",{"name":5,"class":6},1]