[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100600798":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":24,"locations":24,"responsibleParty":28,"collaborators":24,"id":33,"slug":34,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":38,"acronym":39,"eligibilityCriteria":40,"healthyVolunteers":35,"sex":41,"minAge":42,"maxAge":24,"enrollmentInfo":43,"targetDuration":24,"studyType":46,"phases":47,"briefSummary":49,"conditions":50,"keywords":52,"overallStatus":57,"whyStopped":24,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":24},{"fullName":5,"class":6},"ASST Sette Laghi","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intercostal nerve block","ACTIVE_COMPARATOR","Performed by the surgeon intraoperatively before final lung re-expansion, involving the administration of 20 mL of 0.5% levobupivacaine using a 27G needle into the subpleural space of the thoracotomy access site and adjacent intercostal spaces.",[13],"Procedure: Intercostal nerve block",{"label":15,"type":10,"description":16,"interventionNames":17},"Ultrasound-guided ESPB","Performed by an anesthesiologist under surgical asepsis with the patient in a seated position. After identifying the target transverse process, a linear ultrasound probe is placed sagittally approximately 2 cm from the midline. The needle (22G, 50 mm) is inserted in-plane in a cranio-caudal direction until contacting the transverse process. After confirming proper injection by observing anesthetic spread between the erector spinae muscle and transverse process, a total of 30 mL of 0.375% ropivacaine is administered.",[18],"Procedure: Ultrasound-guided ESPB",[20,25],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"PROCEDURE","Before final lung re-expansion, involving the administration of 20 mL of 0.5% levobupivacaine using a 27G needle into the subpleural space of the thoracotomy access site and adjacent intercostal spaces.",[9],null,{"type":21,"name":15,"description":26,"armGroupLabels":27,"otherNames":24},"After identifying the target transverse process, a linear ultrasound probe is placed sagittally approximately 2 cm from the midline. The needle (22G, 50 mm) is inserted in-plane in a cranio-caudal direction until contacting the transverse process. After confirming proper injection by observing anesthetic spread between the erector spinae muscle and transverse process, a total of 30 mL of 0.375% ropivacaine is administered.",[15],{"type":29,"investigatorFullName":30,"investigatorTitle":31,"investigatorAffiliation":32,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Luca Guzzetti","MD","Ospedale di Circolo - Fondazione Macchi","100600798","comparison-of-loco-regional-analgesic-techniques-in-patients-undergoing-video-assisted-thoracoscopic-surgery-vats-100600798",false,"NCT07102173","Comparison of Loco-regional Analgesic Techniques in Patients Undergoing Video Assisted Thoracoscopic Surgery (VATS)","Management Protocol for Comparison of Loco-regional Analgesic Techniques in Patients Undergoing Video Assisted Thoracoscopic Surgery (VATS)","PRoGEVATS","Inclusion Criteria:\n\n* Adult patients\n* Signed informed consent\n* Elective unilateral surgery\n\nExclusion Criteria:\n\n* Minor patients\n* BMI \\> 40\n* Unstable neurological disorders\n* Known allergy to acetaminophen and NSAIDs\n* Chronic renal failure (stage \\> 4, whith GFR between 29 and 15 mL\u002Fmin)\n* Patient refusal\n* Chronic use of NSAIDs and opioids in the 3 months prior to surgery\n* Contraindications to peripheral block (infection al the insertion site, allergy to local anesthetics, severe coagulation disorders)","ALL","18 Years",{"count":44,"type":45},72,"ESTIMATED","INTERVENTIONAL",[48],"NA","This study aims to compare two loco-regional analgesic techniques:\n\n1. Intercostal nerve block: Performed by the surgeon intraoperatively before final lung re-expansion, involving the administration of 20 mL of 0.5% levobupivacaine using a 27G needle into the subpleural space of the thoracotomy access site and adjacent intercostal spaces.\n2. Ultrasound-guided ESPB: Performed by an anesthesiologist under surgical asepsis with the patient in a seated position. After identifying the target transverse process, a linear ultrasound probe is placed sagittally approximately 2 cm from the midline. The needle (22G, 50 mm) is inserted in-plane in a cranio-caudal direction until contacting the transverse process. After confirming proper injection by observing anesthetic spread between the erector spinae muscle and transverse process, a total of 30 mL of 0.375% ropivacaine is administered.\n\nThis protocol is intended for patients undergoing video-assisted thoracoscopic surgery (VATS) for pneumonectomies, lobectomies, wedge resections, and bullectomies.\n\nPrimary Endpoint:QoR Score at 24 hours (validated questionnaires. Secondary Endpoints: Intraoperative NOL, QoR at 48-72 hours, opioid consumption at 12-24-48 hours, NLR at 24 hours, CPSP incidence at 3 months.",[51],"Loco-regional Anesthesia",[53,54,55,56,9],"VATS","post-operative analgesia","loco-regional anesthesia","ESPB","NOT_YET_RECRUITING","2025-07-28",{"date":60,"type":61},"2025-08-03","ACTUAL",{"date":63,"type":45},"2025-08-01",{"date":65,"type":45},"2026-04",{"name":5,"class":6}]