[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100604034":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":25,"responsibleParty":37,"collaborators":25,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":43,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":25,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":65,"whyStopped":25,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":25},{"fullName":5,"class":6},"Mansoura University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Epinephrine group (group E)","ACTIVE_COMPARATOR","The patients receive 0.05-0.1 mcg\u002Fkg\u002Fmin.of epinephrine 5-10 minutes before aortic unclamping",[13],"Drug: Epinephrine",{"label":15,"type":10,"description":16,"interventionNames":17},"Milrinone group (group M)","patients will recieve an initial bolus dose of of 50 µg\u002Fkg, followed by 0.40 -0.80 µg\u002Fkg\u002Fmin 5-10 minutes before aortic unclamping",[18],"Drug: Milrinone Injection",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Epinephrine","Normal saline bolus over 10 min followed by Epinephrine intravenous infusion of 0.05-0.1 mcg\u002Fkg\u002Fmin.of epinephrine 5-10 minutes before aortic unclamping",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Milrinone Injection","Milrinone initial bolus doses of 50 µg\u002Fkg, followed by 0.40 - 0.80 µg\u002Fkg\u002Fmin of milrinone 5-10 minutes before aortic unclamping",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":35,"email":36},"Maha A AboZeid, Assistant professor","CONTACT","01019216192","02","mahazed@yahoo.com",{"type":38,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","maha abou-zeid","Professor of Anesthesia , surgical Intensive care and pain management Faculty of Medicine","100604034","comparison-of-milrinone-and-epinephrine-on-tapse-100604034",false,"NCT07144267","Comparison of Milrinone and Epinephrine on TAPSE","Milrinone Versus Epinephrine for Right Ventricular Dysfunction After Cardiac Surgery in Adults: A Randomized Double-Blinded Trial","Milrinone","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status II \\& III\n* Age between 18 and 70 years\n* Both Gender\n* Body mass index less than 40 kg\u002Fm2\n* Ejection fraction of \\>40%\n* Tricuspid annular plane systolic excursion (TAPSE) \\\u003C 1.7cm\n\nExclusion Criteria:\n\n* Patient refusal.\n* Preoperative RV impairment\n* Pulmonary hypertension (estimated pulmonary artery systolic pressure \\> 50 mmHg)\n* Patients with any contraindications to Transesophageal echocardiography (TEE)\n* Redo or Re-exploration surgery\n* Patients with chronic kidney disease (serum creatinine \\> 1.5 mg\u002F dl)\n* Patients with chronic liver disease (child pugh B and C)","ALL","18 Years","70 Years",{"count":53,"type":54},102,"ESTIMATED","INTERVENTIONAL",[57],"NA","Cardiopulmonary bypass (CPB) is a critical technology in cardiac surgery, allowing for the temporary replacement of the heart and lung functions during intricate surgical procedures. it has significant post-surgical complications, the most important complications of CPB is right ventricle (RV) dysfunction. Diagnosis and management of RV dysfunction is crucial for maintenance of hemodynamic stability and organ function in early post-operation period and prognostic for later phase.",[60,61],"Cardiac Anaesthesia","Cardiopulmonary Bypass",[63,64],"Cardiopulmonary bypass (CPB) -Tricuspid annular plane systolic excursion (TAPSE)-","Epinephrine - Milrinone","NOT_YET_RECRUITING","2026-02-23",{"date":68,"type":69},"2026-02-25","ACTUAL",{"date":71,"type":54},"2026-03-01",{"date":73,"type":54},"2028-03-30",{"name":5,"class":6}]