[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622239":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":11,"centralContacts":37,"locations":11,"responsibleParty":43,"collaborators":11,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":11,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":11,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":11,"overallStatus":67,"whyStopped":11,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":11},{"fullName":5,"class":6},"Sohag University","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Ketamine group","EXPERIMENTAL",null,[13],"Drug: Ketamine nebulizer",{"label":15,"type":10,"description":11,"interventionNames":16},"Mg sulfate group",[17],"Drug: Mg sulfate nebulizer",{"label":19,"type":20,"description":11,"interventionNames":21},"Placebo group","PLACEBO_COMPARATOR",[22],"Drug: Placebo",[24,29,33],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"DRUG","Ketamine nebulizer","50 patients will receive preoperative nebulization with 50 mg ketamine in 5 ml normal saline.",[9],{"type":25,"name":30,"description":31,"armGroupLabels":32,"otherNames":11},"Mg sulfate nebulizer","50 patients will receive preoperative nebulization with 250 mg magnesium sulfate in 5 ml normal saline.",[15],{"type":25,"name":34,"description":35,"armGroupLabels":36,"otherNames":11},"Placebo","50 patients will receive preoperative nebulization with 5 ml normal saline.",[19],[38],{"name":39,"role":40,"phone":41,"phoneExt":11,"email":42},"Shahenda AHMED Ali, Resident","CONTACT","01153378581","Shahenda_ahmed_post@med.sohag.edu.eg",{"type":44,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Shahenda Ahmed Ali","Resident of Anesthesia and surgical Intensive Care unit and Pain Management","100622239","comparison-of-nebulized-ketamine-with-nebulized-magnesium-sulfate-for-the-prevention-of-postoperative-sore-throat-100622239",false,"NCT07381036","Comparison of Nebulized Ketamine With Nebulized Magnesium Sulfate for the Prevention of Postoperative Sore Throat","Comparison of Nebulized Ketamine With Nebulized Magnesium Sulfate for the Prevention of Postoperative Sore Throat in Adult Surgical Patients Undergoing General Anesthesia: Prospective Randomized Controlled Study","Inclusion Criteria:\n\n* Age from 18 to 65 years old.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status I-II.\n* Elective surgery requiring GA with endotracheal intubation.\n\n  \\- Exclusion Criteria:\n* Surgery involves the oral cavity, nasopharynx, larynx, and neck regions.\n* Surgery requires prone position.\n* Surgery lasted more than 3 hours.\n* History of preoperative sore throat, common cold.\n* Anticipated difficult airway.\n* Any known allergies to study drugs.\n* Recent non-steroidal anti-inflammatory drugs use.\n* Pregnancy.",true,"ALL","18 Years","65 Years",{"count":59,"type":60},150,"ESTIMATED","INTERVENTIONAL",[63],"NA","The aim of this study is to compare the efficacy of nebulized ketamine versus nebulized magnesium sulfate in reducing the incidence and severity of POST.\n\n* Primary outcome\n\n  • To compare the incidence of POST method.\n* Secondary outcomes\n\n  * Onset, Severity, and duration of POST at 0, 2, 4, 6, 12, 24 hours postoperative.\n  * The hemodynamics recording (HR, BP, MBP, pre and post nebulization)\n  * Adverse Effects (e.g., sedation, cough, nausea, vomiting, ….)",[66],"Postoperative Sore Throat","NOT_YET_RECRUITING","2026-01-30",{"date":70,"type":71},"2026-02-03","ACTUAL",{"date":73,"type":60},"2026-02-01",{"date":75,"type":60},"2026-09-01",{"name":5,"class":6}]