[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100588596":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":26,"responsibleParty":37,"collaborators":26,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":26,"eligibilityCriteria":47,"healthyVolunteers":43,"sex":48,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":26,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":26,"overallStatus":61,"whyStopped":26,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":26},{"fullName":5,"class":6},"University of Health Sciences Lahore","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Open Appendectomy with Transversus Abdominis Plane (TAP) Block","EXPERIMENTAL","Patients in this group will undergo open appendectomy followed by the administration of a Transversus Abdominis Plane (TAP) block. The TAP block will be performed using a mixture of 10 ml of 1% lignocaine and 10 ml of 0.5% bupivacaine, injected between the transversus abdominis and internal oblique muscles under vision. This intervention is designed to provide localized post-operative analgesia and reduce the need for systemic opioid analgesics.",[13],"Procedure: Transversus Abdominis Plane (TAP) Block for Postoperative Pain Management",{"label":15,"type":16,"description":17,"interventionNames":18},"Open Appendectomy without Transversus Abdominis Plane (TAP) Block","ACTIVE_COMPARATOR","Patients in this group will undergo open appendectomy using the standard surgical technique without the administration of a Transversus Abdominis Plane (TAP) block. Post-operative pain will be managed using standard opioid analgesia as required, without the benefit of the TAP block for localized pain relief.",[19],"Procedure: Standard Open Appendectomy with Postoperative Pain Management",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Transversus Abdominis Plane (TAP) Block for Postoperative Pain Management","The intervention involves the administration of a Transversus Abdominis Plane (TAP) block performed at the end of an open appendectomy surgery. A mixture of 10 ml of 1% lignocaine and 10 ml of 0.5% bupivacaine is injected into the transversus abdominis plane, located between the transversus abdominis and internal oblique muscles, under direct vision. This procedure aims to provide localized pain relief by blocking the sensory nerves of the anterior abdominal wall, reducing the need for systemic opioid analgesics during post-operative recovery",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Standard Open Appendectomy with Postoperative Pain Management","The intervention involves the standard open appendectomy surgical procedure without the addition of a Transversus Abdominis Plane (TAP) block. Postoperative pain management in this group is managed using standard opioid analgesics. No local anesthetic block is performed, and pain management is entirely reliant on systemic medications, including opioids, for post-operative recovery",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Hafiz Rana Kamran Ijaz, MS General Surgery","CONTACT","0331-4745037","beekeeperrkrajput@gmail.com",{"type":38,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Hafiz Rana Kamran Ijaz","Principal Investigator","100588596","comparison-of-outcome-of-open-appendectomy-with-and-without-transversus-abdominis-plane-tap-block-100588596",false,"NCT06943456","Comparison of Outcome of Open Appendectomy With and Without Transversus Abdominis Plane (TAP) Block","Comparison of Outcome of Open Appendectomy With and Without Transversus Abdominis Plane Block","Inclusion Criteria:\n\n* Adults aged 18 to 65 years.\n* Both male and female patients.\n* Patients fit for general anesthesia.\n* Clinical findings of appendicitis.\n* Lower right quadrant or periumbilical pain radiating to the right lower quadrant, with nausea and\u002For vomiting.\n* Fever \\>38°C.\n* Tenderness with Alvarado score \\>7.\n\nExclusion Criteria:\n\n* Duration of symptoms \\>5 days.\n* Absence of clinical findings of appendicitis.\n* Palpable mass on physical examination suspected for appendiceal abscess.\n* History of cirrhosis or hematological disorders.\n* Allergic to or contraindicated for general anesthesia.\n* Pregnancy.\n* Patients who do not consent to participate.","ALL","18 Years","65 Years",{"count":52,"type":53},136,"ESTIMATED","INTERVENTIONAL",[56],"NA","This study is being conducted to compare two types of pain management techniques in patients undergoing open appendectomy (surgical removal of the appendix through a traditional incision).\n\nOne group of patients will receive a Transversus Abdominis Plane (TAP) block, a type of regional anesthesia given at the end of surgery to numb the abdominal area and reduce pain. The other group will undergo the same surgery without receiving the TAP block.\n\nThe purpose of this study is to find out whether adding the TAP block helps in:\n\nReducing postoperative pain\n\nShortening the hospital stay\n\nMinimizing complications like nausea, vomiting, and delayed mobility\n\nImproving patient satisfaction after surgery\n\nOpioid medications are commonly used for pain control after surgery, but they come with side effects such as nausea, vomiting, dizziness, and risk of dependency. TAP block offers a promising alternative that may reduce or eliminate the need for opioids by targeting specific nerves in the abdominal wall.\n\nThis will be a randomized controlled trial (considered the gold standard in medical research), meaning patients will be randomly assigned to one of the two groups to ensure fair comparison. The study will enroll 136 adult patients who are diagnosed with appendicitis and are scheduled for open appendectomy at Jinnah Hospital Lahore.\n\nBy conducting this study, the researchers aim to provide strong scientific evidence on whether TAP block should be routinely used in appendectomy patients to enhance recovery and comfort. If proven effective, this could influence hospital protocols and improve post-surgery care both locally and internationally.",[59,60],"Appendicitis","Postoperative Pain","NOT_YET_RECRUITING","2025-04-24",{"date":64,"type":65},"2025-04-29","ACTUAL",{"date":67,"type":53},"2025-05",{"date":69,"type":53},"2026-05",{"name":5,"class":6}]