[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100590342":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":13,"locations":19,"responsibleParty":38,"collaborators":10,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":10,"eligibilityCriteria":46,"healthyVolunteers":43,"sex":47,"minAge":48,"maxAge":10,"enrollmentInfo":49,"targetDuration":10,"studyType":52,"phases":10,"briefSummary":53,"conditions":54,"keywords":57,"overallStatus":22,"whyStopped":10,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":69},{"fullName":5,"class":6},"Eye & ENT Hospital of Fudan University","OTHER",[8,11],{"label":9,"type":10,"description":10,"interventionNames":10},"conventional phacoemulsification surgery (CPS)",null,{"label":12,"type":10,"description":10,"interventionNames":10},"femtosecond laser-assisted cataract surgery (FLACS)",[14],{"name":15,"role":16,"phone":17,"phoneExt":10,"email":18},"Jin Yang","CONTACT","+86 021-64377134","jin_er76@hotmail.com",[20],{"facility":21,"status":22,"city":23,"state":24,"zip":25,"country":26,"countryCode":27,"cosmosGeoPoint":28,"geoPoint":33,"contacts":34},"Eye and ENT hospital of Fudan University","RECRUITING","Shanghai","Shanghai Municipality","200000","China","CN",{"type":29,"coordinates":30},"Point",[31,32],121.45806,31.22222,{"lat":32,"lon":31},[35],{"name":10,"role":16,"phone":36,"phoneExt":10,"email":37},"15088920668","1532483480@qq.com",{"type":39,"investigatorFullName":15,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Chief Physician","100590342","comparison-of-outcomes-between-femtosecond-laser-assisted-and-conventional-phacoemulsification-in-fuchs-endothelial-corneal-dystrophy-patients-with-cataracts-100590342",false,"NCT06966167","Comparison of Outcomes Between Femtosecond Laser-Assisted and Conventional Phacoemulsification in Fuchs Endothelial Corneal Dystrophy Patients With Cataracts","Inclusion Criteria:\n\n* Patients scheduled for cataract surgery\n* Age ≥40 years\n* Diagnosed with moderate to severe FECD (endothelial cell density \\\u003C1500 cells\u002Fmm²)\n\nExclusion Criteria:\n\n* History of prior intraocular surgery\n* Presence of ocular conditions other than FECD and cataracts (e.g., severe dry eye, corneal scarring, keratoconus, uveitis, uncontrolled glaucoma, vitreoretinal disease)\n* Requirement for additional intraocular procedures during the study period (excluding Nd:YAG posterior capsulotomy)","ALL","40 Years",{"count":50,"type":51},120,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to compare the mid- to long-term efficacy of femtosecond laser-assisted cataract surgery (FLACS) and conventional phacoemulsification surgery (CPS) in patients with moderate to severe Fuchs' endothelial corneal dystrophy (FECD) complicated by cataracts.\n\nThe main questions it aims to answer are:\n\nDoes FLACS lead to better preservation of corneal endothelial cells compared to CPS in patients with moderate to severe FECD? How do visual outcomes and corneal transparency compare between FLACS and CPS in this patient population?\n\nComparison Group:\n\nResearchers will compare patients undergoing FLACS with those undergoing CPS to evaluate differences in endothelial cell loss, corneal thickness, visual acuity, and corneal transparency.\n\nParticipants:\n\nAdults aged 40 years and older diagnosed with moderate to severe FECD (endothelial cell density \\\u003C1500 cells\u002Fmm²).\n\nPatients scheduled for cataract surgery at participating centers.\n\nParticipants will undergo:\n\nPreoperative evaluations, including visual acuity tests, corneal endothelial cell density assessment (central and five peripheral zones), corneal thickness, and corneal densitometry.\n\nSurgical intervention with either FLACS or CPS. Postoperative follow-ups at 1 day, 3 days, 1 week, 1 month, 3 months, 6 months, 1 year, and 2 years, including assessments of endothelial cell density, visual acuity, and corneal thickness.\n\nThis study aims to provide evidence-based recommendations for optimizing surgical strategies in high-risk patients with FECD and cataracts.",[55,56],"Fuchs Endothelial Corneal Dystrophy","Cataract",[55,56,58,59],"Femtosecond Laser-Assisted Cataract Surgery","Conventional Phacoemulsification Surgery","2025-06-16",{"date":62,"type":63},"2025-06-17","ACTUAL",{"date":65,"type":63},"2025-01-01",{"date":67,"type":51},"2030-01",{"name":5,"class":6},1]